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Start Over Area of Honors Biochemistry and Molecular Biology Year 2022

1. An Inside Look on Eutrophication in the Blue Marsh Reservoir by Identifying Cyanobacteria and Their Associated Toxin Genes: A Method to Use Cyanophages to Decrease Harmful Algal Blooms

open_access
Open Access
Author:
Moawad, Rana
Title:
An Inside Look on Eutrophication in the Blue Marsh Reservoir by Identifying Cyanobacteria and Their Associated Toxin Genes: A Method to Use Cyanophages to Decrease Harmful Algal Blooms
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
eutrophication
harmful algal blooms
cyanobacteria
Blue Marsh Reservoir
HABs
cyanophages
water quality
anthropogenic
File:
Download Moawad__Rana_Schreyer_Thesis_May_2022_FINAL_Complete_Submit_.pdf
Thesis Supervisors:
Tami H Mysliwiec, Thesis Supervisor
Sandy Feinstein, Thesis Honors Advisor

2. Exploring the Causes of Muscle Dysfunction Associated with Adenylosuccinate Lyase Deficiency in the Model Organism Caenorhabditis elegans

open_access
Open Access
Author:
Jan, Judy
Title:
Exploring the Causes of Muscle Dysfunction Associated with Adenylosuccinate Lyase Deficiency in the Model Organism Caenorhabditis elegans
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
C. elegans
Muscle Function
Adenylosuccinate Lyase Deficiency
Purine Metabolism
File:
Download Final_Thesis_Draft_Judy_Jan.pdf
Thesis Supervisors:
Wendy Hanna-Rose, Thesis Supervisor
David Scott Gilmour, Thesis Honors Advisor

5. Developing an in vitro Protease Assay for Determining the Transmembrane Topology of SARS-CoV-2 nsp6

open_access
Open Access
Author:
Nasal, Benjamin
Title:
Developing an in vitro Protease Assay for Determining the Transmembrane Topology of SARS-CoV-2 nsp6
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
SARS
COVID
coronavirus
protein topology
transmembrane
protease
microscopy
live cell imaging
western blotting
double membrane vesicle
File:
Download Schreyer_Thesis_FINAL_COPY.pdf
Thesis Supervisors:
Joyce Jose, Thesis Supervisor
Joseph C. Reese, Thesis Honors Advisor

7. The Properties and Location of Anisosome-Forming RNA-binding deficient TAR DNA-binding Protein 43 inside the Nucleus

open_access
Open Access
Author:
Mertick Sykes, Eli
Title:
The Properties and Location of Anisosome-Forming RNA-binding deficient TAR DNA-binding Protein 43 inside the Nucleus
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Protein
Liquid-Liquid Phase Separation
TDP-43
Mammalian Cells
Immunofluorescence
File:
Download Eli_Mertick-Sykes_Thesis_Final.pdf
Thesis Supervisors:
Xin Zhang, Thesis Supervisor
Song Tan, Thesis Honors Advisor

9. Use of Recombinant Urocanase to Study the Inhibitory Effects of Imidazolone Propionate Breakdown Products on Aspartate Aminotransferase

open_access
Open Access
Author:
Ruud, Isabella
Title:
Use of Recombinant Urocanase to Study the Inhibitory Effects of Imidazolone Propionate Breakdown Products on Aspartate Aminotransferase
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
aspartate aminotransferase
urocanase
histidine metabolism
enzyme inhibition
metabolic enzyme deficiencies
File:
Download IAR_Thesis_Final_PDF.pdf
Thesis Supervisors:
Allen T Phillips, Thesis Supervisor
Lorraine C Santy, Thesis Honors Advisor

10. Investigation into the HutD Protein within the Histidine Utilization (hut) Pathway in Pseudomonas putida

open_access
Open Access
Author:
Guzman, Nicholas
Title:
Investigation into the HutD Protein within the Histidine Utilization (hut) Pathway in Pseudomonas putida
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Histidine
Histidine Utilization Pathway (Hut)
HutC
HutD
repressor
promoter
operator
beta-galactosidase
pET vectors
Protein Overexpression
SDS-PAGE
Nickel-IMAC
Molecular Cloning
File:
Download Thesis_Final_Version_-_Guzman.pdf
Thesis Supervisors:
Joseph C. Reese, Thesis Supervisor
Allen T Phillips, Thesis Honors Advisor

11. The Mechanism of NELF Recruitment by DSIF in Promoter-proximal Pausing of RNA Polymerase II

restricted_to_institution
Restricted (Penn State Only)
Author:
Deng, Eilene
Title:
The Mechanism of NELF Recruitment by DSIF in Promoter-proximal Pausing of RNA Polymerase II
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
promoter-proximal pausing
transcription factors
gene regulation
DSIF
NELF
RNA Polymerase II
File:
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Thesis Supervisors:
David Scott Gilmour, Thesis Supervisor
Lorraine C Santy, Thesis Honors Advisor

13. The Effect of the Small RNA RyhB on the Structure of its mRNA Targets

restricted_to_institution
Restricted (Penn State Only)
Author:
Grecco, Samantha
Title:
The Effect of the Small RNA RyhB on the Structure of its mRNA Targets
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
sRNA
RyhB
gene expression profiling
in vivo chemical structure probing
pulldown assay
antibiotic resistance
structure-function relationship
File:
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Thesis Supervisors:
Philip C Bevilacqua, Thesis Supervisor
Ying Gu, Thesis Honors Advisor

15. The Chemotherapeutic Agent CX-5461 Affects Cell Viability Through a Topoisomerase II Poison-Like Mechanism

restricted_to_institution
Restricted (Penn State Only)
Author:
Dennis, Kady
Title:
The Chemotherapeutic Agent CX-5461 Affects Cell Viability Through a Topoisomerase II Poison-Like Mechanism
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
CX-5461
mechanism of action
RNA Polymerase I inhibitor
Topoisomerase II poison
File:
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Thesis Supervisors:
Justin R Pritchard, Thesis Supervisor
Joseph C. Reese, Thesis Honors Advisor

16. Understanding the Mechanisms Controlling the Localization of Microtubule Organization Proteins in Drosophila Neurons

restricted_to_institution
Restricted (Penn State Only)
Author:
Long, Melissa
Title:
Understanding the Mechanisms Controlling the Localization of Microtubule Organization Proteins in Drosophila Neurons
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Drosophila
Neuroscience
Microtubule Nucleation
Clathrin-Mediated Endocytosis
Wnt Signaling
Dendrite
File:
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Thesis Supervisors:
Melissa Rolls, Thesis Supervisor
David Scott Gilmour, Thesis Honors Advisor

17. Development of a Functional RNA-Identifying Computational Pipeline and its Application to SARS-CoV-2

restricted_to_institution
Restricted (Penn State Only)
Author:
Forstmeier, Peter
Title:
Development of a Functional RNA-Identifying Computational Pipeline and its Application to SARS-CoV-2
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
SARS-CoV-2
RNA
pseudoknots
SNPs
RNA structure conservation
frameshifting element
FSE
File:
Login to Download
Thesis Supervisors:
Philip C Bevilacqua, Thesis Supervisor
Teh-Hui Kao, Thesis Honors Advisor