The Minimal Cost of Blood Flow: Murray's Law Revisited

Open Access
Author:
Pisupati, Aditya
Area of Honors:
Engineering Science
Degree:
Bachelor of Science
Document Type:
Thesis
Thesis Supervisors:
  • Patrick James Drew, Thesis Supervisor
  • Bruce Gluckman, Honors Advisor
  • Judith A Todd, Faculty Reader
Keywords:
  • cerebral vasculature
  • Murray's Law
Abstract:
Understanding how blood vessels of the brain remodel in response to metabolic changes is very important to understanding the progression of various disease states such as stroke and Alzheimer’s disease. One area within vascular research that is not well understood is how the blood vessels of the brain, particularly the arteriolar networks, are organized. In this thesis, blood vessel diameters and lengths were measured after being filled with FITC-Albumin. The measurements were then used to test the validity of a newly derived mathematical relation that is based on Murray’s Law.