Comprehensive Review of the Default-mode Network and Directions for Future Research

Open Access
Waters, Lee M
Area of Honors:
Bachelor of Science
Document Type:
Thesis Supervisors:
  • Frank Gerard Hillary, Thesis Supervisor
  • Stephen Wade Schaeffer, Honors Advisor
  • Default-mode network
  • DMN
  • fMRI
  • PET
The goal of this critical review is to provide a comprehensive review of the default-mode network (DMN) – a network of brain regions that is active when an individual is not focused on the outside world. A brief description of the default-mode network’s history and anatomy will be provided, followed by a discussion of its putative role in disease and recovery. The latter will entail a discussion that encompasses autism, schizophrenia, Alzheimer’s disease, anxiety and depression, epilepsy, ADHD, and traumatic brain injury. This thesis is intended to benefit future authors and facilitate the advancement of study within the field.