A device for measuring intracranial pressure and neuronal potentials in a small laboratory animal
Open Access
Author:
Graybill, Philip Patrick
Area of Honors:
Interdisciplinary in Electrical Engineering and Engineering Science
Degree:
Bachelor of Science
Document Type:
Thesis
Thesis Supervisors:
Bruce Gluckman, Thesis Supervisor Mehdi Kiani, Thesis Supervisor Jeffrey Scott Mayer, Thesis Honors Advisor Huanyu Cheng, Faculty Reader
Keywords:
intracranial pressure measurement local field potentials wireless transmission epilepsy SUDEP
Abstract:
Sudden unexpected death in epilepsy (SUDEP) has a significant impact on public health in terms of years of potential life lost. While the physiological mechanisms surrounding SUDEP remain poorly understood, a low-cost wireless device that could simultaneously measure intracranial pressure (ICP) and local field potentials (LFPs) in an epileptic animal model would provide a useful tool for researchers seeking to gain insight into the relationship between ICP and SUDEP. The prototype described in this paper is the first step toward achieving such a device. The prototype was designed to achieve requirements for signal gain, sampling rate, sample bit depth, and band-pass filter cutoff frequencies in a configuration using wireless transmission and wired power. The device meets the requirements as expected and is ready for further development toward a completely wireless version.
