BIO-MECHANICAL EVALUATION OF COLLAGEN TYPE-I SCAFFOLDS FOR BONE TISSUE REGENERATION
Open Access
Author:
McFadden, Ryan B
Area of Honors:
Engineering Science
Degree:
Bachelor of Science
Document Type:
Thesis
Thesis Supervisors:
Dr. Ibrahim Tarik Ozbolat, Thesis Supervisor Judith A Todd Copley, Thesis Honors Advisor Dr. Lucas Jay Passmore, Faculty Reader
Keywords:
bio-mechanics stress-strain compressive evaluation collagen-nHA scaffold bone tissue regeneration
Abstract:
In modern medicine, regeneration of tissue is an ultimate goal. The ability to heal a defect that originated from birth, an accident, or any other situation is something that is being actively pursued. In this research, the end goal is to regenerate the bone tissue of a critical size defect which is created in vivo on a rodent. This is completed by plugging the defect site with a bio- compatible hydrogel solution composed of collagen type-I, fibrinogen, thrombin, transglutimase, and nano-hydroxyapatite. In this thesis, the plug (created by manual pipetting or pneumatic based bioprinting) is mechanically evaluated to investigate its mechanical integrity in vitro. By obtaining the compressive elastic modulus of the hydrogel, the strength and elasticity of the plug can be understood. This is crucial in predicting the effectiveness of the plug to regenerate and stimulate growth of the native bone during incubation.
