Impact of Pulsatility and Flow Rates on Hemodynamic Energy Transmission in an Adult ECLS System

Open Access
Wolfe, Rachel Morgan
Area of Honors:
Biomedical Engineering
Bachelor of Science
Document Type:
Thesis Supervisors:
  • Akif Undar, Thesis Supervisor
  • Nanyin Zhang, Honors Advisor
  • Extracorporeal life support
  • Diagonal pump
  • XLung oxygenator
  • Adult
  • Pulsatile flow
The objective of this study is to investigate the total hemodynamic energy (THE) and surplus hemodynamic energy (SHE) transmission of a novel adult Extracorporeal Life Support (ECLS) system with non-pulsatile and pulsatile settings and varying pulsatility. The study intends to provide insight into what level of pulsatility is the most effective setting in this ECLS system. The pump should supply maximal hemodynamic energy values at lower flow rates and medium pulsatility settings, with minimal pressure and energy losses. There are three specific aims of the study. The first is to locate the key points of the ECLS circuit that have high pressure drops. These points are the most important to consider in where to improve the efficiency of the circuit. The second specific aim is to compare the accepted literature values for pressure and hemodynamic energy to the values generated by each setting of the system. Comparing these values allows the circuit to be validated for future use in a clinical setting. Finally, the third specific aim is to identify the pump settings that generate maximum energy delivery to the pseudo patient. This aim is the most important to the overall study because it will help to identify what pump settings allow most energy delivery. Consequently, patient populations can be identified who align with these settings, which this circuit may be recommended to once it is implemented clinically. Together, these specific aims attempt to quantify the energy delivery of the circuit and pulsatile pump, and determine whether it can progress to one day being implemented clinically.