Friend Virus - Anemia (FV-A) Effects on Stress Erythropoiesis within the Spleen

Open Access
Author:
Azzara, Kyle D.
Area of Honors:
Immunology and Infectious Disease
Degree:
Bachelor of Science
Document Type:
Thesis
Thesis Supervisors:
  • Robert F. Paulson, Thesis Supervisor
  • Pamela Hankey, Honors Advisor
Keywords:
  • Stress Erythropoiesis
  • Friend Virus
  • Friend Virus - Anemia
Abstract:
Friend Virus is a murine retrovirus that causes erythroleukemia in adult mice. Friend Virus has two major forms, Friend Virus – Polycythemia (FV-P) and Friend Virus – Anemia (FV-A). Although both forms of the virus lead to erythroleukemia in mice, FV-P leads to polycythemia, while FV-A leads to anemia. The cells that are infected by the virus are part of the stress erythropoiesis pathway. Friend Virus induces the expansion of stress erythroid progenitors that become the targets for the virus. When early “stem cell like” progenitors are infected they proliferate and form self-renewing leukemia stem cells (LSCs), while infection of late stage progenitors lead to differentiation. Previous analysis of Friend Virus targets characterized mice infected with FV-P. This study examines FV-A and how it affects the stress erythropoietic progenitor cells. My data show that FV-A LSCs have a more limited self-renewal ability than FV-P LSCs.