The Relationship Between Fornix Volume and Memory Following Moderate-Severe Traumatic Brain Injury

Open Access
Benson, Monica Ann
Area of Honors:
Letters, Arts, and Sciences (University College)
Bachelor of Arts
Document Type:
Thesis Supervisors:
  • Dr. Frank Hillary, Thesis Supervisor
  • John Selzer, Honors Advisor
  • Traumatic Brain Injury
  • Fornix
Due to the variability of traumatic brain injuries and the large population affected, research to understand brain changes following injury is vital. Advanced neuroimaging technology such as 3T MRI scanners allow for a detailed look at brain anatomy though T1- weighted images. Little research has investigated the fornix, a major output path of the hippocampus. The fornix has a speculated role in memory, but little research has investigated if TBI affects the fornix, or if fornix morphology predicts performance in recall, recognition, or memory at all. The current study examines fornix volumes and neuropsychology test scores in TBI and age and education matched healthy control subjects to examine the role of the fornix in memory post injury. Results show decreased fornix volumes and lower memory scores in the TBI sample compared to HC. Reduced fornix volume maintained modest relationships to memory performance. Future studies should include a larger sample size in order to detect the relationship between fornix volume and memory functioning after TBI.