EFFECT OF 1,3-THIAZOLIDIN-4-ONES ON HELA AND GIST-T1 CELL PROLIFERATION IN VITRO

Open Access
Author:
Alkurdi, Alaa
Area of Honors:
Letters, Arts, and Sciences (Abington)
Degree:
Bachelor of Science
Document Type:
Thesis
Thesis Supervisors:
  • Eric Paul Ingersoll, Thesis Supervisor
  • David E Ruth, Honors Advisor
  • Kevin Charles Cannon, Thesis Supervisor
Keywords:
  • 4-thiazolidinones
  • HeLa
  • GIST
  • Cancer
  • Biology
Abstract:
4-thiazolidinones have been reported as a potential drug-like molecule due to their possible anticancer and antiproliferation properties in cancer cell lines. The effects of five different novel 1,3-thiazolidin-4-ones compounds on human cervical (HeLa) and gastrointestinal stromal tumor (GIST-T1) cell lines in vitro were observed. The HeLa and GIST-T1 cells were grown in culture and treated with 0-400 μM concentrations for 48 hours. Cell growth was measured by absorbance and resulted in a decrease of cell proliferation; 0-100 μM showed moderate growth, whereas 200-400 μM treatment resulted in minimal to no growth. The compounds varied in substituent (F, Br, Cl) and placement (ortho, para). Results indicated a correlation between para position and decreased growth. These results agree that there are possible implications of 4-thiazolidinones possessing anticancer properties and should be further evaluated for possible mechanisms and uses.