Comparative in vitro Bioavailability of Dietary Flavonoids in Oral Cancer Cells
Open Access
Author:
Jantip, Aom
Area of Honors:
Food Science
Degree:
Bachelor of Science
Document Type:
Thesis
Thesis Supervisors:
Joshua D Lambert, Thesis Supervisor Federico Miguel Harte, Thesis Honors Advisor
Keywords:
Oral cancer Flavonoids Polyphenols Cellular uptake
Abstract:
Oral cancer is in the top 10 most common cancer worldwide and is a leading cause of death. In our previous study, it was found that minor differences in flavonoid structure led to more significant differences in anticancer activity---the cytotoxic effects of flavonoids of interest against oral cancer were compared and ranked from the most to the least: Apigenin > Fisetin > Naringenin > Chrysin > Eriodictyol > Quercetin. Many studies demonstrated that the uptake of flavonoids into cells determines their biological actions, such as the mechanism underlying cytotoxicity. Therefore, this study aimed to quantify the cellular uptake of flavonoids by oral cancer cells in order to understand the relationship between the cellular uptake and their cytotoxicity. It is hypothesized that the cellular uptake of these flavonoids by oral cancer cells predicts their cytotoxicity. However, the hypothesis was rejected. Further studies are needed to determine and quantify the metabolites of flavonoids formed by the oral cancer cells, as several researchers have reported that flavonoid metabolites can retain anticancer activities.
