Illuminating the relationship between gut characteristics and brain behavior will further develop both gastrointestinal and enteric as well as psychiatric research. Reduced barrier function, inflammation, and reduced absorption capacity are gut characteristics in people with environmental enteric dysfunction, a small intestine syndrome. This syndrome is particularly prevalent in low-income countries. Therefore, to further develop the relationship between gut health and psychophysiological health, gut biomarkers (neopterin, myeloperoxidase, alpha-1-antitrypsin, lactulose, mannitol, and REGB1) were compared to oxidative stress biomarkers (alpha-amylase, F2-isoprostanes, and cortisol) in children from Bangladesh, meta-analysis revealed no significant association between the EED biomarkers measured and oxidative stress. The strongest association found was between alpha-1-antitrypsin with both cortisol and salivary alpha-amylase (P < 0.05), although in opposite directions. Implications of these findings for further study are discussed.
