Obesity in the United States is a critical public health issue that is associated with a number of chronic diseases including an increased risk of type II diabetes, cardiovascular diseases, certain cancers, and mental health disorders. Proanthocyanidins are a type of polyphenolic compounds found in numerous fruits, vegetables, nuts, seeds, and beverages, such as tea and red wine. Proanthocyanidins have garnered attention due to their potential health benefits. One of these health benefits includes the ability to inhibit the digestive enzyme pancreatic lipase. By inhibiting pancreatic lipase, proanthocyanidins can reduce the breakdown of fats into absorbable fatty acids and glycerol. By limiting the absorption of dietary fats, proanthocyanidins may contribute to a decrease in body fat accumulation over time. This research study examines the effect of seven locally sourced wine grape samples on pancreatic lipase inhibition via the use of a pancreatic lipase assay. This research study found that the variety and location of wine grape sample had no effect on degree of inhibition. However, this study also found that the addition of Chambourcin and Cabernet Franc grape extracts effectively decreased pancreatic lipase activity; suggesting that the consumption of proanthocyanidins found in wine grapes may be a viable dietary method of supporting weight reduction and management.
