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Start Over Thesis Supervisor Dr. Justin Lee Brown

2. The effect of substrate stiffness on fibrillin expression by mouse embryonic fibroblasts (MEFs)

open_access
Open Access
Author:
Sheldrake, Anne E
Title:
The effect of substrate stiffness on fibrillin expression by mouse embryonic fibroblasts (MEFs)
Area of Honors:
Bioengineering
Keywords:
MEFs
tissue engineering
cardiac
acrylamide
bisacrylamide
heart
fibrillin
scar tissue
File:
Download sheldrake_anne_effect_of_susbstrate_stiffness.pdf
Thesis Supervisors:
Dr. Justin Lee Brown, Thesis Supervisor
Peter J Butler, Thesis Honors Advisor
Dr. William O Hancock, Faculty Reader

4. Nanofiber Control of Focal Adhesion Dynamics and Cell Migration for Regenerative Medicine

open_access
Open Access
Author:
Riley, Thomas Roberts
Title:
Nanofiber Control of Focal Adhesion Dynamics and Cell Migration for Regenerative Medicine
Area of Honors:
Bioengineering
Keywords:
Matlab
Image Processing
Focal Adhesion
Cell Migration
Nanofiber
Tissue Engineering
Regenerative Medicine
FAITS
File:
Download RileyThesisFinalDraft.pdf
Thesis Supervisors:
Dr. Justin Lee Brown, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Peter J Butler, Faculty Reader

5. Single-molecule microscopy step detection algorithms: kinesin motor proteins and the cellulose synthesis complex

open_access
Open Access
Author:
Deffenbaugh, Nathan C
Title:
Single-molecule microscopy step detection algorithms: kinesin motor proteins and the cellulose synthesis complex
Area of Honors:
Bioengineering
Keywords:
kinesin
motor proteins
step detection
single-molecule
cellulose synthesis complex
hidden Markov model
File:
Download DeffenbaughNathan_SHCThesis_May2015.pdf
Thesis Supervisors:
Dr. William O Hancock, Thesis Supervisor
Peter J Butler, Faculty Reader
Dr. Justin Lee Brown, Faculty Reader
Dr. William O Hancock, Thesis Honors Advisor

6. β-Catenin Signaling Leading to the Maintenance and Differentiation of MC3T3 Cells in Response to Electrospun Nanofibers

open_access
Open Access
Author:
Nagurney, Rebecca Ann
Title:
β-Catenin Signaling Leading to the Maintenance and Differentiation of MC3T3 Cells in Response to Electrospun Nanofibers
Area of Honors:
Bioengineering
Keywords:
Nanofibers
Electrospinning
PMMA
PolyHEMA
Polyvinyl Alcohol
Beta-Catenin
Osteogenesis
File:
Download Nagurney_FinalThesis_BIOE_2016.pdf
Thesis Supervisors:
Dr. Justin Lee Brown, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor

7. Factors Impacting the Efficacy of Cell-mediated Drug Delivery to the Brain via the Blood Brain Barrier

open_access
Open Access
Author:
Selvi, Erhan Yavuz
Title:
Factors Impacting the Efficacy of Cell-mediated Drug Delivery to the Brain via the Blood Brain Barrier
Area of Honors:
Bioengineering
Keywords:
cell-mediated drug delivery
blood brain barrier
VE-cadherin
VCAM-1
ICAM-1
VLA-4
LFA-1
transendothelial migration
File:
Download SCHREYER_THESIS_4.11.16_final.pdf
Thesis Supervisors:
Cheng Dong, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Dr. Justin Lee Brown, Faculty Reader

8. THE EFFECT OF NANOFIBER DIAMETERS ON INTEGRIN REGULATED FAK-SRC SIGNALLING AND MIGRATION RATES OF HUMAN MESENCHYMAL STEM CELLS

open_access
Open Access
Author:
Mcculloch, Mary Elizabeth
Title:
THE EFFECT OF NANOFIBER DIAMETERS ON INTEGRIN REGULATED FAK-SRC SIGNALLING AND MIGRATION RATES OF HUMAN MESENCHYMAL STEM CELLS
Area of Honors:
Biomedical Engineering
Keywords:
FAK
SRC
Tissue Engineering
hMSCs
migration
Focal adhesions
File:
Download HonorsFINALThesisDraft.pdf
Thesis Supervisors:
Dr. Justin Lee Brown, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor

10. Membrane Microdomains Regulate Focal Adhesion Size in Bovine Aortic Endothelial Cells

open_access
Open Access
Author:
Culver, Margaret Frances
Title:
Membrane Microdomains Regulate Focal Adhesion Size in Bovine Aortic Endothelial Cells
Area of Honors:
Biomedical Engineering
Keywords:
Focal Adhesion
Lipid Rafts
Non-lipid amphiphiles
File:
Download Final_Thesis_for_submission_pdf.pdf
Thesis Supervisors:
Peter J Butler, Thesis Supervisor
Peter J Butler, Thesis Honors Advisor
Dr. Justin Lee Brown, Faculty Reader

11. An Investigation Into The Nanofiber-induced Epigenetic Changes In Mesenchymal Stem Cells

open_access
Open Access
Author:
Swatski, Matthew David
Title:
An Investigation Into The Nanofiber-induced Epigenetic Changes In Mesenchymal Stem Cells
Area of Honors:
Biomedical Engineering
Keywords:
epigenetics
nanofibers
PMMA
biomaterials
regenerative medicine
stem cells
tissue engineering
biomedical engineering
File:
Download Thesis.pdf
Thesis Supervisors:
Dr. Justin Lee Brown, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Jian Yang, Faculty Reader

12. Determining the Effect of Kinesin-5 Inhibitors on the Nucleation Rates of Microtubules in vitro and Synthesizing, Characterizing, and Purifying Fluorescently Labeled Nucleotides

open_access
Open Access
Author:
Lingafelt, Colin Mark
Title:
Determining the Effect of Kinesin-5 Inhibitors on the Nucleation Rates of Microtubules in vitro and Synthesizing, Characterizing, and Purifying Fluorescently Labeled Nucleotides
Area of Honors:
Biomedical Engineering
Keywords:
kinesins
microtubules
fluorescent nucleotides
binding rates
synthesis
Eg5
nucleation
tubulin
critical concentration
File:
Download thesis_ColinLingafelt_04102017_final.pdf
Thesis Supervisors:
Dr. William O Hancock, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Dr. Justin Lee Brown, Faculty Reader
Herbert Herling Lipowsky, Faculty Reader

13. VISUALIZATION AND QUANTITATION OF STEM CELL MEDIATED MINERALIZATION OF A DEMINERALIZED COLLAGEN SAFFOLD IN A TISSUE ENGINEERING MODEL

open_access
Open Access
Author:
McKellar, Brian U
Title:
VISUALIZATION AND QUANTITATION OF STEM CELL MEDIATED MINERALIZATION OF A DEMINERALIZED COLLAGEN SAFFOLD IN A TISSUE ENGINEERING MODEL
Area of Honors:
Biomedical Engineering
Keywords:
Tissue Engineering
Bone
Biomineralization
Osteogenic differentiation
Stem cell
File:
Download McKellar_EpiBone_Thesis_FinalSchreyer_links.pdf
Thesis Supervisors:
Dr. Justin Lee Brown, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor

15. The impact of genetic variants on kinesin motor proteins and the link to neurological disorders

open_access
Open Access
Author:
Erdman, Marcus Orion
Title:
The impact of genetic variants on kinesin motor proteins and the link to neurological disorders
Area of Honors:
Biomedical Engineering
Keywords:
kinesin
neurological disorder
mutation
genomics
File:
Download Thesis_final_Marcus_Erdman.pdf
Thesis Supervisors:
Dr. William O Hancock, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Peter J Butler, Faculty Reader
Dr. Justin Lee Brown, Faculty Reader

16. CALCIUM DOPED CITRATE BOUND BIOMATERIALS FOR MULTIFUNCTIONAL ORTHOPEDIC TISSUE ENGINEERING APPLICATIONS

open_access
Open Access
Author:
Fadel, John Elias
Title:
CALCIUM DOPED CITRATE BOUND BIOMATERIALS FOR MULTIFUNCTIONAL ORTHOPEDIC TISSUE ENGINEERING APPLICATIONS
Area of Honors:
Biomedical Engineering
Keywords:
Bone
orthopedics
orthopedic engineering
tissue engineering
bone implant
polymer
polymer engineering
characterization
materials
File:
Download Final_Thesis_Draft_FADEL.pdf
Thesis Supervisors:
Jian Yang, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Dr. Justin Lee Brown, Faculty Reader

17. EXPERIMENTAL PLATFORM SIMULATING THE MECHANICAL EFFECTS OF DIAPHRAGMATIC MOTION ON INFERIOR VENA CAVA COLLAPSIBILITY

open_access
Open Access
Author:
Crompton, Philip Edward
Title:
EXPERIMENTAL PLATFORM SIMULATING THE MECHANICAL EFFECTS OF DIAPHRAGMATIC MOTION ON INFERIOR VENA CAVA COLLAPSIBILITY
Area of Honors:
Biomedical Engineering
Keywords:
IVC filter
IVC collapse
diaphragmatic motion
inferior vena cava
File:
Download Crompton_Thesis2.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Dr. Justin Lee Brown, Thesis Honors Advisor

18. Investigating the Impact of Flow Recirculation on Cellular Uptake of Nanoparticles

open_access
Open Access
Author:
Boland, Samuel Fares
Title:
Investigating the Impact of Flow Recirculation on Cellular Uptake of Nanoparticles
Area of Honors:
Biomedical Engineering
Keywords:
nanoparticles
atherosclerosis
flow chamber
finite element analysis
drug delivery
fluid dynamics
cell mechanics
File:
Download Boland_Thesis_Final.pdf
Thesis Supervisors:
Peter J Butler, Thesis Supervisor
Dr. Justin Lee Brown, Thesis Honors Advisor

19. THE EFFECTS OF CELL MORPHOLOGY ON NANOPARTICLE UPTAKE AND UPTAKE AT THE LEADING EDGE IN MC3T3 CELLS

open_access
Open Access
Author:
Li, Harvey S
Title:
THE EFFECTS OF CELL MORPHOLOGY ON NANOPARTICLE UPTAKE AND UPTAKE AT THE LEADING EDGE IN MC3T3 CELLS
Area of Honors:
Biomedical Engineering
Keywords:
Biomedical engineering
cell morphology
cell culture
microcontact printing
immunostaining
immunofluorescence
live-cell imaging
cell leading edge
cell
y-27632
File:
Download Honors_Thesis_FINAL_v2.pdf
Thesis Supervisors:
Dr. Justin Lee Brown, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor

20. THE ROLE OF MECHANICALLY GATED ION CHANNELS IN REGULATING THE RESPONSE OF MESENCHYMAL STEM CELLS TO NANOFIBER ARCHITECTURE

open_access
Open Access
Author:
Wandling, Grant Donald
Title:
THE ROLE OF MECHANICALLY GATED ION CHANNELS IN REGULATING THE RESPONSE OF MESENCHYMAL STEM CELLS TO NANOFIBER ARCHITECTURE
Area of Honors:
Biomedical Engineering
Keywords:
Nanofibers
TREK-1
hMSCs
osteoblasts
File:
Download Thesis.pdf
Thesis Supervisors:
Dr. Justin Lee Brown, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor

21. DEVELOPMENT OF A NOVEL MAGNESIUM DOPED CITRATE BASED POLYMER COMPOSITE FOR ORTHOPEDIC ENGINEERING

open_access
Open Access
Author:
Rahn, Kevin Michael
Title:
DEVELOPMENT OF A NOVEL MAGNESIUM DOPED CITRATE BASED POLYMER COMPOSITE FOR ORTHOPEDIC ENGINEERING
Area of Honors:
Biomedical Engineering
Keywords:
bone
bone engineering
orthopedic engineering
citrate-based materials
magnesium oxide
polymer
tissue engineering
injection molding
File:
Download Kevin_Rahn_Honors_Thesis.pdf
Thesis Supervisors:
Jian Yang, Thesis Supervisor
Jian Yang, Thesis Honors Advisor
Dr. Justin Lee Brown, Faculty Reader

22. THE EFFECT OF MICROFIBER MORPHOLOHY AND CELL DENSITY ON THE LOCALIZATION OF YAP PROTEIN IN MESENCHYMAL STEM CELLS

open_access
Open Access
Author:
Steltz, Austin E
Title:
THE EFFECT OF MICROFIBER MORPHOLOHY AND CELL DENSITY ON THE LOCALIZATION OF YAP PROTEIN IN MESENCHYMAL STEM CELLS
Area of Honors:
Biomedical Engineering
Keywords:
mesenchymal stem cell
msc
YAP
Yes Associated Protein
Mechanotransduction
Transduce
biology
biomedical engineering
electrospinning
fibers
flat
File:
Download Austin_Steltz_thesis.pdf
Thesis Supervisors:
Dr. Justin Lee Brown, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Yong Wang, Faculty Reader

26. Studying Thrombosis and Surface Roughness in the Penn State Pediatric Ventricular Assist Device

open_access
Open Access
Author:
Richardsen, Cecilia
Title:
Studying Thrombosis and Surface Roughness in the Penn State Pediatric Ventricular Assist Device
Area of Honors:
Biomedical Engineering
Keywords:
thrombosis
heart
surface roughness
bridge to transplant
PVAD
artificial organ
polyurethane
platelets
fibrin
File:
Download Richardsen_Thesis_Final_SHC_.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Dr. Justin Lee Brown, Thesis Honors Advisor

28. SURFACE CHARACTERISTICS OF IMPLANTABLE LONG-TERM USE FONTAN PUMP MATERIALS

open_access
Open Access
Author:
Mc Hugh, Clare Moire
Title:
SURFACE CHARACTERISTICS OF IMPLANTABLE LONG-TERM USE FONTAN PUMP MATERIALS
Area of Honors:
Biomedical Engineering
Keywords:
Biomaterials
Biomedical Engineering
Fontan Circulation
Fluid Mechanics
Biocompatibility
Platelet Adhesion
Thrombosis
Medical Device
File:
Download McHugh_Thesis.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Dr. Justin Lee Brown, Thesis Honors Advisor

29. Yes-associated protein 1 localization in response to substrate architecture

open_access
Open Access
Author:
Chan, Coreena
Title:
Yes-associated protein 1 localization in response to substrate architecture
Area of Honors:
Biomedical Engineering
Keywords:
YAP
YAP1
yes-associated protein
yes-associated protein 1
nanofibers
osteogenesis
osteogenic differentiation
RhoA
FAK
focal adhesions
tissue engineering
Hippo signaling pathway
cancer
tumor suppression
File:
Download Chan_Coreena_Honors_Thesis_SP19.pdf
Thesis Supervisors:
Dr. Justin Lee Brown, Thesis Supervisor
Timothy J Jegla, Thesis Honors Advisor

30. Brownian Dynamics Simulation of Kinesin

open_access
Open Access
Author:
Cook, Zeke
Title:
Brownian Dynamics Simulation of Kinesin
Area of Honors:
Biomedical Engineering
Keywords:
Kinesin
Protein
Motor
Mechanobiology
Mechanochemistry
Processive
Fluorescence
Gold Nanoparticle
Tracking
Total Internal Reflection
Microscopy
Interferometric Scattering
Brownian
Dynamics
Brownian Dynamics
Molecular Modeling
Molecular Dynamics
File:
Download Cook_Annan_BrownianDynamicsSimulationofKinesinMotorProteinDynamics.pdf
Thesis Supervisors:
Dr. William O Hancock, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Dr. Justin Lee Brown, Faculty Reader