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Start Over Degree B S Thesis Supervisor Dr. William O Hancock

1. THE ROLE OF CYTOSKELETON PROTEINS IN THE DETERMINATION OF NEURONAL POLARITY

open_access
Open Access
Author:
Han, Anna Q.
Title:
THE ROLE OF CYTOSKELETON PROTEINS IN THE DETERMINATION OF NEURONAL POLARITY
Area of Honors:
Bioengineering
Keywords:
cytoskeleton proteins
cofilin
slingshot
LIM kinase
neuronal polarity
hippocampal neurons
File:
Download Han.Anna.Spring_2010_Thesis.pdf
Thesis Supervisors:
Dr. Gong Chen, Thesis Supervisor
Dr. Gong Chen, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Peter J Butler, Faculty Reader

2. THE EFFECTS OF THE TUMOR MICROENVIRONMENT ON ENDOTHELIAL CELLULAR ADHESION MOLECULE EXPRESSION

open_access
Open Access
Author:
Goodrich, Christopher James
Title:
THE EFFECTS OF THE TUMOR MICROENVIRONMENT ON ENDOTHELIAL CELLULAR ADHESION MOLECULE EXPRESSION
Area of Honors:
Bioengineering
Keywords:
cancer
metastasis
adhesion
ICAM-1
File:
Download Thesis_Reviewed_Final_-_Christopher_Goodrich.pdf
Thesis Supervisors:
Cheng Dong, Thesis Supervisor
Cheng Dong, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Peter J Butler, Faculty Reader

4. A Computational Study of Airflow in a Standardized Human Nasal Cavity: Implications Regarding Olfaction

open_access
Open Access
Author:
Shenk, Elizabeth Marie
Title:
A Computational Study of Airflow in a Standardized Human Nasal Cavity: Implications Regarding Olfaction
Area of Honors:
Bioengineering
Keywords:
human olfaction
nasal airflow
standardized human nasal cavity
CFD analysis
File:
Download Shenk_Thesis.pdf
Thesis Supervisors:
Brent A Craven, Thesis Supervisor
Brent A Craven, Thesis Supervisor
Dr. William O Hancock, Thesis Supervisor
Peter J Butler, Faculty Reader

5. The Effects of Combination Zoledronate and Docetaxel Therapy on Breast Cancer Colonization of Three-Dimensional Osteoblastic Tissue

open_access
Open Access
Author:
Miller, Genevieve Nicole
Title:
The Effects of Combination Zoledronate and Docetaxel Therapy on Breast Cancer Colonization of Three-Dimensional Osteoblastic Tissue
Area of Honors:
Bioengineering
Keywords:
breast cancer
bone metastasis
bisphosphonate
File:
Download Miller_Genevieve_Honors_Thesis_2010.pdf
Thesis Supervisors:
Erwin A Vogler, Thesis Supervisor
Erwin A Vogler, Thesis Supervisor
Andrea Marie Mastro, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor

7. PARTICLE SORTING WITH SURFACE ACOUSTIC WAVES (SAW) FOR A FULLY INTEGRATED MICROFLUIDIC FLOW CYTOMETER

open_access
Open Access
Author:
Pisupati, Karthik
Title:
PARTICLE SORTING WITH SURFACE ACOUSTIC WAVES (SAW) FOR A FULLY INTEGRATED MICROFLUIDIC FLOW CYTOMETER
Area of Honors:
Bioengineering
Keywords:
microfluidic
surface acoustic wave
sorting
File:
Download karthikpisupati_thesis.pdf
Thesis Supervisors:
Jun Huang, Thesis Supervisor
Jun Huang, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Siyang Zheng, Faculty Reader

8. Improving Carbon Fiber Microelectrode Performance for Measuring Serotonin by Voltammetry

open_access
Open Access
Author:
Sawarynski, Lauren Elizabeth
Title:
Improving Carbon Fiber Microelectrode Performance for Measuring Serotonin by Voltammetry
Area of Honors:
Bioengineering
Keywords:
serotonin
carbon fiber microelectrodes
voltammetry
File:
Download LSawarynski_FinalThesis.pdf
Thesis Supervisors:
Dr. Anne Milasincic Andrews, Ph D, Thesis Supervisor
Dr. Anne Milasincic Andrews, Ph D, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Peter J Butler, Faculty Reader

10. AORTIC OUTLET EXTENSION IN THE 12CC PENN STATE PEDIATRIC VENTRICULAR ASSIST DEVICE

open_access
Open Access
Author:
Fickes, Michael Glenn
Title:
AORTIC OUTLET EXTENSION IN THE 12CC PENN STATE PEDIATRIC VENTRICULAR ASSIST DEVICE
Area of Honors:
Bioengineering
Keywords:
outlet valve extension
blockage
PVAD
File:
Download Michael_Fickes_Honors_Thesis_Schreyers.pdf
Thesis Supervisors:
Keefe B Manning, Thesis Supervisor
Dr. Keefe B Manning, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Steven Deutsch, Faculty Reader

11. The Challenges of Implanting the Penn State Pediatric Ventricular Assist Device: Study of the Ascending Aorta Anastomotic Flow

open_access
Open Access
Author:
Perone, Michael Vincent
Title:
The Challenges of Implanting the Penn State Pediatric Ventricular Assist Device: Study of the Ascending Aorta Anastomotic Flow
Area of Honors:
Bioengineering
Keywords:
Penn State PVAD
anastomosis
File:
Download Perone_-_Honors_Thesis.pdf
Thesis Supervisors:
Keefe B Manning, Thesis Supervisor
Dr. Keefe B Manning, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Steven Deutsch, Faculty Reader

12. THE EFFECTS OF MULTIPLE KINESIN MOTORS ON CARGO TRANSPORT VELOCITY

open_access
Open Access
Author:
Bizzaro, Nicholas Robert
Title:
THE EFFECTS OF MULTIPLE KINESIN MOTORS ON CARGO TRANSPORT VELOCITY
Area of Honors:
Bioengineering
Keywords:
motor proteins
kinesin
cellular transport
File:
Download Schreyer_Honors_College_Thesis_-_Nicholas_Bizzaro.pdf
Thesis Supervisors:
Dr. William O Hancock, Thesis Supervisor
Dr. William O Hancock, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Peter J Butler, Faculty Reader
Margaret June Slattery, Faculty Reader

13. THE CHARACTERIZATION OF A MICROCHANNEL DEVICE USING LASER BASED MICRO-PIV

open_access
Open Access
Author:
Wang , Sicong
Title:
THE CHARACTERIZATION OF A MICROCHANNEL DEVICE USING LASER BASED MICRO-PIV
Area of Honors:
Bioengineering
Keywords:
microchannel
microfluidics
micro-PIV
soft lithography
murray law
circulating tumor cell
velocity profile
volumetric flow rate
pulastive flow
PDMS
File:
Download THECHARACTERIZATION_OF_MICROCHANNEL_DEVICE_USING_LASER_BASEDMICROPIV.pdf
Thesis Supervisors:
Siyang Zheng, Thesis Supervisor
Siyang Zheng, Thesis Supervisor
Peter J Butler, Thesis Honors Advisor
Dr. William O Hancock, Faculty Reader

14. DEVELOPMENT AND CHARACTERIZATION OF EXTRACELLULAR AND INTRACELLULAR TARGETS IN TUMOR-INDUCED ENDOTHELIAL JUNCTION REGULATIONS

open_access
Open Access
Author:
Yunkunis, Tara Marie
Title:
DEVELOPMENT AND CHARACTERIZATION OF EXTRACELLULAR AND INTRACELLULAR TARGETS IN TUMOR-INDUCED ENDOTHELIAL JUNCTION REGULATIONS
Area of Honors:
Bioengineering
Keywords:
signaling
VE-cadherin
calcium
File:
Download Yunkunis_Thesis_SHC_FINAL.pdf
Thesis Supervisors:
Cheng Dong, Thesis Supervisor
Cheng Dong, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor

15. Modeling the Roll-Slip Nonlinear Dynamics of the Knee

open_access
Open Access
Author:
Gagliardi, Virginia Marie
Title:
Modeling the Roll-Slip Nonlinear Dynamics of the Knee
Area of Honors:
Bioengineering
Keywords:
knee
knee joint
prosthetics
dynamics of the knee
roll-slide
roll-slip
oscillator
File:
Download Gagliardi_Thesis_Spring_2010.pdf
Thesis Supervisors:
Joseph Paul Cusumano, Thesis Supervisor
Joseph Paul Cusumano, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Margaret June Slattery, Faculty Reader

17. Feasibility Studies for Optical Trap Detection of Single Molecule Adhesion and Force Generation

open_access
Open Access
Author:
Bernick, David J
Title:
Feasibility Studies for Optical Trap Detection of Single Molecule Adhesion and Force Generation
Area of Honors:
Bioengineering
Keywords:
optical trap
laser tweezers
integrin ligand binding
bead
avidin
biotin
microscopy
File:
Download Final_Thesis_Bernick_David_Optical_Trap.pdf
Thesis Supervisors:
Peter J Butler, Thesis Supervisor
Peter J Butler, Thesis Honors Advisor
Dr. Keefe B Manning, Faculty Reader
Dr. William O Hancock, Faculty Reader

19. Finite Element Analysis of Microfabricated Poly(Glycerol Sebacate) Scaffolds for use in Heart Valve Tissue Engineering

open_access
Open Access
Author:
Chowdhury, Surjyanil
Title:
Finite Element Analysis of Microfabricated Poly(Glycerol Sebacate) Scaffolds for use in Heart Valve Tissue Engineering
Area of Honors:
Bioengineering
Keywords:
Chowdhury
finite element
COMSOL
heart valve
tissue engineering
poly glycerol sebacate
PGS
microfabricate
scaffold
mesh
File:
Download honors_thesis_final_draft.pdf
Thesis Supervisors:
Dr. William O Hancock, Thesis Supervisor
Peter J Butler, Thesis Honors Advisor
Dr. Keefe B Manning, Faculty Reader

20. The effect of substrate stiffness on fibrillin expression by mouse embryonic fibroblasts (MEFs)

open_access
Open Access
Author:
Sheldrake, Anne E
Title:
The effect of substrate stiffness on fibrillin expression by mouse embryonic fibroblasts (MEFs)
Area of Honors:
Bioengineering
Keywords:
MEFs
tissue engineering
cardiac
acrylamide
bisacrylamide
heart
fibrillin
scar tissue
File:
Download sheldrake_anne_effect_of_susbstrate_stiffness.pdf
Thesis Supervisors:
Dr. Justin Lee Brown, Thesis Supervisor
Peter J Butler, Thesis Honors Advisor
Dr. William O Hancock, Faculty Reader

24. Encapsulation of Docetaxel in Calcium Phosphosilicate Nanoparticles and the Effects of Bioconjugation

open_access
Open Access
Author:
Hughes, Kelly E
Title:
Encapsulation of Docetaxel in Calcium Phosphosilicate Nanoparticles and the Effects of Bioconjugation
Area of Honors:
Bioengineering
Keywords:
nanoparticles
breast cancer
cancer
calcium phosphate
File:
Download Hughes_Honors_Thesis.pdf
Thesis Supervisors:
Cheng Dong, Thesis Supervisor
James Hansell Adair, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor

26. An In Vitro Investigation of the Effect of Shear on von Willebrand Factor Proteolysis

open_access
Open Access
Author:
Burke, Shannon Leigh
Title:
An In Vitro Investigation of the Effect of Shear on von Willebrand Factor Proteolysis
Area of Honors:
Bioengineering
Keywords:
von Willebrand factor
vWF
ventricular assist device
VAD
proteolysis
heart failure
cardiovascular disease
File:
Download Shannon_Burke_-_Thesis.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Dr. Keefe B Manning, Thesis Honors Advisor
Dr. William O Hancock, Faculty Reader
Margaret June Slattery, Faculty Reader

28. Fluid Dynamic Studies of a Porcine Aortic Valve in Preparation for Future Living Tissue Valve Studies

open_access
Open Access
Author:
Schmiech, Kathryn Victoria
Title:
Fluid Dynamic Studies of a Porcine Aortic Valve in Preparation for Future Living Tissue Valve Studies
Area of Honors:
Bioengineering
Keywords:
aortic valve
fluid dynamics
porcine valve
particle image velocimetry
File:
Download KSchmiechFinalThesis.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Peter J Butler, Faculty Reader

29. Investigating the Mechanics of Cancer Cell Membranes Using Microfluidics

open_access
Open Access
Author:
Ramadi, Khalil Basil
Title:
Investigating the Mechanics of Cancer Cell Membranes Using Microfluidics
Area of Honors:
Bioengineering
Keywords:
Cancer
CTC
Isolation
Characterization
Tumor
Membrane
Mechanics
Cell
Expansion
Osmosis
Microfluidics
Viscoelasticity
File:
Download Thesis_Final_final_v2.pdf
Thesis Supervisors:
Siyang Zheng, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Peter J Butler, Faculty Reader

30. Effects of Synonymous, Consecutive, Repetitive Codons on Bacterial Translation Elongation Rates

open_access
Open Access
Author:
Heasley, Victoria Lynn
Title:
Effects of Synonymous, Consecutive, Repetitive Codons on Bacterial Translation Elongation Rates
Area of Honors:
Bioengineering
Keywords:
repetitive codon sequences elongation
affects on translation elongation rates
synthetic biology
genetic engineering
File:
Download Heasley_Victoria__Effects_of_Repetitive_Codons_on_Elongation.pdf
Thesis Supervisors:
Howard M Salis, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Peter J Butler, Faculty Reader

31. The Effect of Blood on Circulating Tumor Cells' Expression of Epithelial and Mesenchymal Cell Markers

open_access
Open Access
Author:
Clabbers, Andrea Laurie
Title:
The Effect of Blood on Circulating Tumor Cells' Expression of Epithelial and Mesenchymal Cell Markers
Area of Honors:
Bioengineering
Keywords:
Circulating Tumor Cells
EpCAM
Epithelial to Mesenchymal Transition
File:
Download Andrea_Clabbers_Thesis_Final.pdf
Thesis Supervisors:
Siyang Zheng, Thesis Supervisor
Sheereen Majd, Thesis Honors Advisor
Dr. William O Hancock, Faculty Reader

32. The Effect of Consumption of the Probiotic Bifidobacterium Animalis Subspecies Lactis (BB-12) on Function and Phenotype of Natural Killer Cells

open_access
Open Access
Author:
Krisher, Sarah Yelena
Title:
The Effect of Consumption of the Probiotic Bifidobacterium Animalis Subspecies Lactis (BB-12) on Function and Phenotype of Natural Killer Cells
Area of Honors:
Bioengineering
Keywords:
probiotics
BB-12
natural killer cells
File:
Download Sarah_Krisher__Final_Thesis_Submission.pdf
Thesis Supervisors:
Connie Jo Rogers, Thesis Supervisor
Sheereen Majd, Thesis Honors Advisor
Dr. William O Hancock, Faculty Reader

33. An Experimental Setup to Test the Effects of Shear Stress on von Willebrand Factor

open_access
Open Access
Author:
Corsetti, Monica Claire
Title:
An Experimental Setup to Test the Effects of Shear Stress on von Willebrand Factor
Area of Honors:
Bioengineering
Keywords:
von Willebrand Factor
vWF
Optical Trap
Optical Tweezers
Shear Stress
Acquired von Willebrand Syndrome
ADAMTS-13
File:
Download Thesis_Monica_Corsetti.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Peter J Butler, Faculty Reader
Dr. William O Hancock, Faculty Reader
Dr. Keefe B Manning, Thesis Honors Advisor

34. Nanofiber Control of Focal Adhesion Dynamics and Cell Migration for Regenerative Medicine

open_access
Open Access
Author:
Riley, Thomas Roberts
Title:
Nanofiber Control of Focal Adhesion Dynamics and Cell Migration for Regenerative Medicine
Area of Honors:
Bioengineering
Keywords:
Matlab
Image Processing
Focal Adhesion
Cell Migration
Nanofiber
Tissue Engineering
Regenerative Medicine
FAITS
File:
Download RileyThesisFinalDraft.pdf
Thesis Supervisors:
Dr. Justin Lee Brown, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Peter J Butler, Faculty Reader

35. In Vitro and Computational Analysis of the Fluid Mechanics Promoting Thrombus Formation in a Backward-facing Step Flow Domain

open_access
Open Access
Author:
Witmer, Kory P
Title:
In Vitro and Computational Analysis of the Fluid Mechanics Promoting Thrombus Formation in a Backward-facing Step Flow Domain
Area of Honors:
Bioengineering
Keywords:
thrombosis
fluid mechanics
computational fluid dynamics
cardiovascular devices
magnetic resonance imaging
File:
Download Schreyer_FinalThesis_Witmer_Kory.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Dr. Keefe B Manning, Thesis Honors Advisor
Dr. William O Hancock, Faculty Reader

36. Histological Analysis of in vitro Thrombus Formation in a Backward Facing Step Flow Domain Using Carstairs' Stain

open_access
Open Access
Author:
Kinney, Joanna E
Title:
Histological Analysis of in vitro Thrombus Formation in a Backward Facing Step Flow Domain Using Carstairs' Stain
Area of Honors:
Bioengineering
Keywords:
thrombosis
histology
bioengineering
heart
blood
File:
Download Kinney_Joanna_Thesis_Final.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Peter J Butler, Faculty Reader

37. A Fluid Dynamic Study of the Effect of Hematocrit in the 12 cc Penn State Pediatric Ventricular Assist Device

open_access
Open Access
Author:
Silver, Jeremy Michael
Title:
A Fluid Dynamic Study of the Effect of Hematocrit in the 12 cc Penn State Pediatric Ventricular Assist Device
Area of Honors:
Bioengineering
Keywords:
ventricular assist device
pediatric
cardiovascular device
hematocrit
thrombosis
particle image velocimetry
piv
VAD
PVAD
File:
Download Silver_SHC_Thesis_FINAL.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Dr. Keefe B Manning, Thesis Honors Advisor
Dr. William O Hancock, Faculty Reader
Peter J Butler, Faculty Reader

38. Targeted Sequencing Of Chromosome 9 Genes Associated With Papillary Type 1 Renal Cell Carcinoma

open_access
Open Access
Author:
Belsky, Michael Alan
Title:
Targeted Sequencing Of Chromosome 9 Genes Associated With Papillary Type 1 Renal Cell Carcinoma
Area of Honors:
Biomedical Engineering
Keywords:
Cancer
next generation sequencing
renal cell carcinoma
targeted sequencing
papillary type 1
File:
Download Belsky_Thesis_Final.pdf
Thesis Supervisors:
Dr. William O Hancock, Thesis Supervisor
Peter J Butler, Thesis Honors Advisor
Dr. William A La Framboise, Faculty Reader

39. Single-molecule microscopy step detection algorithms: kinesin motor proteins and the cellulose synthesis complex

open_access
Open Access
Author:
Deffenbaugh, Nathan C
Title:
Single-molecule microscopy step detection algorithms: kinesin motor proteins and the cellulose synthesis complex
Area of Honors:
Bioengineering
Keywords:
kinesin
motor proteins
step detection
single-molecule
cellulose synthesis complex
hidden Markov model
File:
Download DeffenbaughNathan_SHCThesis_May2015.pdf
Thesis Supervisors:
Dr. William O Hancock, Thesis Supervisor
Peter J Butler, Faculty Reader
Dr. Justin Lee Brown, Faculty Reader
Dr. William O Hancock, Thesis Honors Advisor

41. A Study in the Design of an Accelerated Wear Tester that is Compatible with a Particle Image Velocimetry and High Speed Camera Setup

open_access
Open Access
Author:
Brown, Edward Alexander
Title:
A Study in the Design of an Accelerated Wear Tester that is Compatible with a Particle Image Velocimetry and High Speed Camera Setup
Area of Honors:
Bioengineering
Keywords:
Accelerated Wear Tester
Particle Image Velocimetry
AWT
PIV
Heart Valve
Artificial Heart Valve
Fluid Dynamics
File:
Download Edward_A_Brown_Honors_Thesis.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Dr. Keefe B Manning, Thesis Honors Advisor
Dr. William O Hancock, Faculty Reader

42. Development of A Multi-layered Micro-patterned Electrospun Mesh for Hernia Repair

open_access
Open Access
Author:
Orr, Sara A
Title:
Development of A Multi-layered Micro-patterned Electrospun Mesh for Hernia Repair
Area of Honors:
Bioengineering
Keywords:
electrospin
electrospun
hernia
mesh
File:
Download 1-Orr_Sara_TheDevelopmentofAMultiLayeredMicroPatternedElectrospunMeshforHerniaRepair.pdf
Thesis Supervisors:
Jian Yang, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Yong Wang, Faculty Reader

43. Modeling the Bidirectional Transport of Intracellular Cargos by Oppositely-directed Motor Proteins

open_access
Open Access
Author:
Mentley, Brandon Scott
Title:
Modeling the Bidirectional Transport of Intracellular Cargos by Oppositely-directed Motor Proteins
Area of Honors:
Bioengineering
Keywords:
kinesin
dynein
motor protein
bidirectional transport
matlab
simulation
File:
Download Brandon_Mentley_-_Thesis_Final_Fall15.pdf
Thesis Supervisors:
Dr. William O Hancock, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
John Fricks, Faculty Reader

44. THE EFFECTS OF BIOCONJUGATION OF CALCIUM PHOSPHOSILICATE NANOPARTICLES ON THE DELIVERY TO BREAST CANCER CELLS

open_access
Open Access
Author:
Gonzalez, Virginia Laura
Title:
THE EFFECTS OF BIOCONJUGATION OF CALCIUM PHOSPHOSILICATE NANOPARTICLES ON THE DELIVERY TO BREAST CANCER CELLS
Area of Honors:
Bioengineering
Keywords:
Calcium Phosphosilicate
Nanoparticles
Breast Cancer
Transendothelial Migration
File:
Download Honors_Thesis_VLG.pdf
Thesis Supervisors:
Cheng Dong, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor

45. β-Catenin Signaling Leading to the Maintenance and Differentiation of MC3T3 Cells in Response to Electrospun Nanofibers

open_access
Open Access
Author:
Nagurney, Rebecca Ann
Title:
β-Catenin Signaling Leading to the Maintenance and Differentiation of MC3T3 Cells in Response to Electrospun Nanofibers
Area of Honors:
Bioengineering
Keywords:
Nanofibers
Electrospinning
PMMA
PolyHEMA
Polyvinyl Alcohol
Beta-Catenin
Osteogenesis
File:
Download Nagurney_FinalThesis_BIOE_2016.pdf
Thesis Supervisors:
Dr. Justin Lee Brown, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor

46. Factors Impacting the Efficacy of Cell-mediated Drug Delivery to the Brain via the Blood Brain Barrier

open_access
Open Access
Author:
Selvi, Erhan Yavuz
Title:
Factors Impacting the Efficacy of Cell-mediated Drug Delivery to the Brain via the Blood Brain Barrier
Area of Honors:
Bioengineering
Keywords:
cell-mediated drug delivery
blood brain barrier
VE-cadherin
VCAM-1
ICAM-1
VLA-4
LFA-1
transendothelial migration
File:
Download SCHREYER_THESIS_4.11.16_final.pdf
Thesis Supervisors:
Cheng Dong, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Dr. Justin Lee Brown, Faculty Reader

47. The Investigation of the Uptake of Interleukin-13 Conjugated Nanoparticles into Glioma Cells

open_access
Open Access
Author:
Porter, Michael John
Title:
The Investigation of the Uptake of Interleukin-13 Conjugated Nanoparticles into Glioma Cells
Area of Honors:
Biomedical Engineering
Keywords:
Nanoparticle
Nanoparticles
IL-13
Interleukin
Glioma
GBM
Glioblastoma multiforme
conjugated
computational
kinetics
File:
Download Final_Thesis_Porter.pdf
Thesis Supervisors:
Sheereen Majd, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Herbert Herling Lipowsky, Faculty Reader

48. THE EFFECT OF NANOFIBER DIAMETERS ON INTEGRIN REGULATED FAK-SRC SIGNALLING AND MIGRATION RATES OF HUMAN MESENCHYMAL STEM CELLS

open_access
Open Access
Author:
Mcculloch, Mary Elizabeth
Title:
THE EFFECT OF NANOFIBER DIAMETERS ON INTEGRIN REGULATED FAK-SRC SIGNALLING AND MIGRATION RATES OF HUMAN MESENCHYMAL STEM CELLS
Area of Honors:
Biomedical Engineering
Keywords:
FAK
SRC
Tissue Engineering
hMSCs
migration
Focal adhesions
File:
Download HonorsFINALThesisDraft.pdf
Thesis Supervisors:
Dr. Justin Lee Brown, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor

49. Comparing Novel Techniques for Measuring the Bending Modulus of Lipid Bilayer Membranes in Erythrocytes

open_access
Open Access
Author:
Frazzette, Nicholas James
Title:
Comparing Novel Techniques for Measuring the Bending Modulus of Lipid Bilayer Membranes in Erythrocytes
Area of Honors:
Bioengineering
Keywords:
mechanobiology
bending modulus
mechanotransduction
lipid bilayers
membrane bending
erythrocytes
TCSPC
fluorescence
File:
Download Frazzette_SHC_Thesis_v4.pdf
Thesis Supervisors:
Peter J Butler, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Herbert Herling Lipowsky, Faculty Reader

51. Characterizing Melanoma Adhesion Dynamics: Thrombin Mediated Interactions and Polymorphic Neutrophil Deformability

open_access
Open Access
Author:
Lee, Deborah Snyder
Title:
Characterizing Melanoma Adhesion Dynamics: Thrombin Mediated Interactions and Polymorphic Neutrophil Deformability
Area of Honors:
Bioengineering
Keywords:
melanoma
polymorphic neutrophils
cellular adhesions
flow assays
bioengineering
cancer
thrombin
fibrin
endothelium
File:
Download undergraduate_thesis_deborah_lee_FINAL.pdf
Thesis Supervisors:
Cheng Dong, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Yong Wang, Faculty Reader

53. An Investigation Into The Nanofiber-induced Epigenetic Changes In Mesenchymal Stem Cells

open_access
Open Access
Author:
Swatski, Matthew David
Title:
An Investigation Into The Nanofiber-induced Epigenetic Changes In Mesenchymal Stem Cells
Area of Honors:
Biomedical Engineering
Keywords:
epigenetics
nanofibers
PMMA
biomaterials
regenerative medicine
stem cells
tissue engineering
biomedical engineering
File:
Download Thesis.pdf
Thesis Supervisors:
Dr. Justin Lee Brown, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Jian Yang, Faculty Reader

55. Melanoma Extravasation Through the Endothelium Affects Focal Adhesion Disassembly

open_access
Open Access
Author:
Eswar, Vikram Jayraj
Title:
Melanoma Extravasation Through the Endothelium Affects Focal Adhesion Disassembly
Area of Honors:
Biomedical Engineering
Keywords:
melanoma
Src
focal adhesion
endothelium
traction force
vinculin
contractility
extravasation
File:
Download Eswar_Thesis.pdf
Thesis Supervisors:
Cheng Dong, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Esther Winter Gomez, Faculty Reader

57. Determining the Effect of Kinesin-5 Inhibitors on the Nucleation Rates of Microtubules in vitro and Synthesizing, Characterizing, and Purifying Fluorescently Labeled Nucleotides

open_access
Open Access
Author:
Lingafelt, Colin Mark
Title:
Determining the Effect of Kinesin-5 Inhibitors on the Nucleation Rates of Microtubules in vitro and Synthesizing, Characterizing, and Purifying Fluorescently Labeled Nucleotides
Area of Honors:
Biomedical Engineering
Keywords:
kinesins
microtubules
fluorescent nucleotides
binding rates
synthesis
Eg5
nucleation
tubulin
critical concentration
File:
Download thesis_ColinLingafelt_04102017_final.pdf
Thesis Supervisors:
Dr. William O Hancock, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Dr. Justin Lee Brown, Faculty Reader
Herbert Herling Lipowsky, Faculty Reader

58. RELATIONSHIP OF PLATELET ADHESION WITH SURFACE TOPOGRAPHY IN THE PENN STATE PEDIATRIC VENTRICULAR ASSIST DEVICE

open_access
Open Access
Author:
Mueser, Ashlyn S
Title:
RELATIONSHIP OF PLATELET ADHESION WITH SURFACE TOPOGRAPHY IN THE PENN STATE PEDIATRIC VENTRICULAR ASSIST DEVICE
Area of Honors:
Biomedical Engineering
Keywords:
PVAD
Platelet Adhesion
Surface Topography
Pediatric Ventricular Assist Devices
File:
Download Thesis.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor

59. VISUALIZATION AND QUANTITATION OF STEM CELL MEDIATED MINERALIZATION OF A DEMINERALIZED COLLAGEN SAFFOLD IN A TISSUE ENGINEERING MODEL

open_access
Open Access
Author:
McKellar, Brian U
Title:
VISUALIZATION AND QUANTITATION OF STEM CELL MEDIATED MINERALIZATION OF A DEMINERALIZED COLLAGEN SAFFOLD IN A TISSUE ENGINEERING MODEL
Area of Honors:
Biomedical Engineering
Keywords:
Tissue Engineering
Bone
Biomineralization
Osteogenic differentiation
Stem cell
File:
Download McKellar_EpiBone_Thesis_FinalSchreyer_links.pdf
Thesis Supervisors:
Dr. Justin Lee Brown, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor

60. The impact of genetic variants on kinesin motor proteins and the link to neurological disorders

open_access
Open Access
Author:
Erdman, Marcus Orion
Title:
The impact of genetic variants on kinesin motor proteins and the link to neurological disorders
Area of Honors:
Biomedical Engineering
Keywords:
kinesin
neurological disorder
mutation
genomics
File:
Download Thesis_final_Marcus_Erdman.pdf
Thesis Supervisors:
Dr. William O Hancock, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Peter J Butler, Faculty Reader
Dr. Justin Lee Brown, Faculty Reader

61. A Study of the Effect of Hematocrit on Weaning in the 12 cc Penn State Pediatric Ventricular Assist Device

open_access
Open Access
Author:
Gallagher, Maureen Brenna
Title:
A Study of the Effect of Hematocrit on Weaning in the 12 cc Penn State Pediatric Ventricular Assist Device
Area of Honors:
Biomedical Engineering
Keywords:
PVAD
artificial heart
hematocrit
weaning
fluid dynamics
File:
Download Gallagher_Schreyer_Thesis_FINAL.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Dr. Keefe B Manning, Thesis Honors Advisor
Dr. William O Hancock, Faculty Reader
Dr. William O Hancock, Faculty Reader

62. Design, construction, and testing of a pneumatic vibrotactile stimulus system for use with awake, behaving mice

open_access
Open Access
Author:
Cook, Alexander Philip
Title:
Design, construction, and testing of a pneumatic vibrotactile stimulus system for use with awake, behaving mice
Area of Honors:
Biomedical Engineering
Keywords:
Neurovascular coupling
Electrophysiology
Passive touch
Pneumatic system
Vibrotactile stimulus
File:
Download Cook_Alexander_PneumaticSystem.pdf
Thesis Supervisors:
Patrick James Drew, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Dr. Nanyin Zhang, Faculty Reader

63. Pulsatile Assessment Of The FDA Computational Study Of Fluid Flow In Biomedical Devices

open_access
Open Access
Author:
Kessler, Joshua C
Title:
Pulsatile Assessment Of The FDA Computational Study Of Fluid Flow In Biomedical Devices
Area of Honors:
Biomedical Engineering
Keywords:
FDA
Turbulence
Computational Fluid Dynamics
CFD
LDV
Benchmark Nozzle Model
Critical Path Initiative
Pulsatile Flow
File:
Download Thesisv_schreyer.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Dr. Pak Kin Wong, Faculty Reader

64. CHARACTERIZATION OF THROMBI THROUGH MRI AND HISTOLOGICAL ANALYSIS OF ERYTHROCYTE GHOST CLOTS

open_access
Open Access
Author:
Hagenah, Kristen E
Title:
CHARACTERIZATION OF THROMBI THROUGH MRI AND HISTOLOGICAL ANALYSIS OF ERYTHROCYTE GHOST CLOTS
Area of Honors:
Biomedical Engineering
Keywords:
Ghost Cells
Quantitative Susceptibility Mapping
Left Ventricular Thrombus
File:
Download Hagenah_Kristen_Schreyer_Thesis_Final_.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor

65. CALCIUM DOPED CITRATE BOUND BIOMATERIALS FOR MULTIFUNCTIONAL ORTHOPEDIC TISSUE ENGINEERING APPLICATIONS

open_access
Open Access
Author:
Fadel, John Elias
Title:
CALCIUM DOPED CITRATE BOUND BIOMATERIALS FOR MULTIFUNCTIONAL ORTHOPEDIC TISSUE ENGINEERING APPLICATIONS
Area of Honors:
Biomedical Engineering
Keywords:
Bone
orthopedics
orthopedic engineering
tissue engineering
bone implant
polymer
polymer engineering
characterization
materials
File:
Download Final_Thesis_Draft_FADEL.pdf
Thesis Supervisors:
Jian Yang, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Dr. Justin Lee Brown, Faculty Reader

66. A CONTROL STUDY USING DNA TO TEST THE EFFECTS OF SHEAR STRESS ON VON WILLEBRAND FACTOR

open_access
Open Access
Author:
Jankowska, Maya Ann-Marie
Title:
A CONTROL STUDY USING DNA TO TEST THE EFFECTS OF SHEAR STRESS ON VON WILLEBRAND FACTOR
Area of Honors:
Biomedical Engineering
Keywords:
von willebrand factor
vwf
optical trap
fluid shear
LVADS
plasmid
fluid mechanics
optical tweezers
shear stress
acquired von willebrand syndrome
File:
Download vWF_Thesis_wTemplate_Maya2.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor

68. EXPLORING THE EFFECTS OF BINGE ALCOHOL DRINKING IN THE RAT

open_access
Open Access
Author:
Cramer, Samuel Reed
Title:
EXPLORING THE EFFECTS OF BINGE ALCOHOL DRINKING IN THE RAT
Area of Honors:
Interdisciplinary in Biomedical Engineering and Neuroscience
Keywords:
ethanol
alcohol
resting state fmri
fmri
functional connectivity
binge
retrosplenial cortex
amygdala
hippocampus
zona incerta
File:
Download OFFICIAL_honors_thesis_template_FINAL.pdf
Thesis Supervisors:
Dr. Nanyin Zhang, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Ping Li, Thesis Honors Advisor

69. THE FUNCTIONAL CONNECTIVITY CHANGES IN THE RAT BRAIN FOLLOWING ACUTE AND CHRONIC NICOTINE ADMINISTRATION

open_access
Open Access
Author:
Roby, Alison C
Title:
THE FUNCTIONAL CONNECTIVITY CHANGES IN THE RAT BRAIN FOLLOWING ACUTE AND CHRONIC NICOTINE ADMINISTRATION
Area of Honors:
Biomedical Engineering
Keywords:
functional connectivity
nicotine
individual difference
acute response
File:
Download thesis_Roby_Alison_final_links.pdf
Thesis Supervisors:
Dr. Nanyin Zhang, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor

70. Assessment of Demographic, Anthropometric, and Physical Performance Variables As Predictors of Sprint Cycling Power

open_access
Open Access
Author:
Mellen, James Scott
Title:
Assessment of Demographic, Anthropometric, and Physical Performance Variables As Predictors of Sprint Cycling Power
Area of Honors:
Biomedical Engineering
Keywords:
cycling
vertical jump
wearable measurement device
sprint
File:
Download James_Mellen_Thesis_Final_Draft__3-30-18_.pdf
Thesis Supervisors:
Giampietro Luciano Vairo, Thesis Supervisor
Jian Yang, Thesis Honors Advisor
Dr. William O Hancock, Faculty Reader

71. THE EFFECTS OF CELL MORPHOLOGY ON NANOPARTICLE UPTAKE AND UPTAKE AT THE LEADING EDGE IN MC3T3 CELLS

open_access
Open Access
Author:
Li, Harvey S
Title:
THE EFFECTS OF CELL MORPHOLOGY ON NANOPARTICLE UPTAKE AND UPTAKE AT THE LEADING EDGE IN MC3T3 CELLS
Area of Honors:
Biomedical Engineering
Keywords:
Biomedical engineering
cell morphology
cell culture
microcontact printing
immunostaining
immunofluorescence
live-cell imaging
cell leading edge
cell
y-27632
File:
Download Honors_Thesis_FINAL_v2.pdf
Thesis Supervisors:
Dr. Justin Lee Brown, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor

73. THE ROLE OF MECHANICALLY GATED ION CHANNELS IN REGULATING THE RESPONSE OF MESENCHYMAL STEM CELLS TO NANOFIBER ARCHITECTURE

open_access
Open Access
Author:
Wandling, Grant Donald
Title:
THE ROLE OF MECHANICALLY GATED ION CHANNELS IN REGULATING THE RESPONSE OF MESENCHYMAL STEM CELLS TO NANOFIBER ARCHITECTURE
Area of Honors:
Biomedical Engineering
Keywords:
Nanofibers
TREK-1
hMSCs
osteoblasts
File:
Download Thesis.pdf
Thesis Supervisors:
Dr. Justin Lee Brown, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor

74. THE EFFECT OF MICROFIBER MORPHOLOHY AND CELL DENSITY ON THE LOCALIZATION OF YAP PROTEIN IN MESENCHYMAL STEM CELLS

open_access
Open Access
Author:
Steltz, Austin E
Title:
THE EFFECT OF MICROFIBER MORPHOLOHY AND CELL DENSITY ON THE LOCALIZATION OF YAP PROTEIN IN MESENCHYMAL STEM CELLS
Area of Honors:
Biomedical Engineering
Keywords:
mesenchymal stem cell
msc
YAP
Yes Associated Protein
Mechanotransduction
Transduce
biology
biomedical engineering
electrospinning
fibers
flat
File:
Download Austin_Steltz_thesis.pdf
Thesis Supervisors:
Dr. Justin Lee Brown, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Yong Wang, Faculty Reader

75. Determining Embolus Trapping Efficiency of an Inferior Vena Cava Filter during Exercise

open_access
Open Access
Author:
Riley, Joshua Mackey
Title:
Determining Embolus Trapping Efficiency of an Inferior Vena Cava Filter during Exercise
Area of Honors:
Biomedical Engineering
Keywords:
Inferior Vena Cava Filter
IVC Filter
Pulmonary Embolism
Trapping Efficiency
File:
Download Riley_Final_Thesis.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Peter J Butler, Faculty Reader

78. Brownian Dynamics Simulation of Kinesin

open_access
Open Access
Author:
Cook, Zeke
Title:
Brownian Dynamics Simulation of Kinesin
Area of Honors:
Biomedical Engineering
Keywords:
Kinesin
Protein
Motor
Mechanobiology
Mechanochemistry
Processive
Fluorescence
Gold Nanoparticle
Tracking
Total Internal Reflection
Microscopy
Interferometric Scattering
Brownian
Dynamics
Brownian Dynamics
Molecular Modeling
Molecular Dynamics
File:
Download Cook_Annan_BrownianDynamicsSimulationofKinesinMotorProteinDynamics.pdf
Thesis Supervisors:
Dr. William O Hancock, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Dr. Justin Lee Brown, Faculty Reader