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1. THE ROLE OF CYTOSKELETON PROTEINS IN THE DETERMINATION OF NEURONAL POLARITY

open_access
Open Access
Author:
Han, Anna Q.
Title:
THE ROLE OF CYTOSKELETON PROTEINS IN THE DETERMINATION OF NEURONAL POLARITY
Area of Honors:
Bioengineering
Keywords:
cytoskeleton proteins
cofilin
slingshot
LIM kinase
neuronal polarity
hippocampal neurons
File:
Download Han.Anna.Spring_2010_Thesis.pdf
Thesis Supervisors:
Dr. Gong Chen, Thesis Supervisor
Dr. Gong Chen, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Peter J Butler, Faculty Reader

4. THE EFFECTS OF THE TUMOR MICROENVIRONMENT ON ENDOTHELIAL CELLULAR ADHESION MOLECULE EXPRESSION

open_access
Open Access
Author:
Goodrich, Christopher James
Title:
THE EFFECTS OF THE TUMOR MICROENVIRONMENT ON ENDOTHELIAL CELLULAR ADHESION MOLECULE EXPRESSION
Area of Honors:
Bioengineering
Keywords:
cancer
metastasis
adhesion
ICAM-1
File:
Download Thesis_Reviewed_Final_-_Christopher_Goodrich.pdf
Thesis Supervisors:
Cheng Dong, Thesis Supervisor
Cheng Dong, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Peter J Butler, Faculty Reader

6. A Computational Study of Airflow in a Standardized Human Nasal Cavity: Implications Regarding Olfaction

open_access
Open Access
Author:
Shenk, Elizabeth Marie
Title:
A Computational Study of Airflow in a Standardized Human Nasal Cavity: Implications Regarding Olfaction
Area of Honors:
Bioengineering
Keywords:
human olfaction
nasal airflow
standardized human nasal cavity
CFD analysis
File:
Download Shenk_Thesis.pdf
Thesis Supervisors:
Brent A Craven, Thesis Supervisor
Brent A Craven, Thesis Supervisor
Dr. William O Hancock, Thesis Supervisor
Peter J Butler, Faculty Reader

7. The Effects of Combination Zoledronate and Docetaxel Therapy on Breast Cancer Colonization of Three-Dimensional Osteoblastic Tissue

open_access
Open Access
Author:
Miller, Genevieve Nicole
Title:
The Effects of Combination Zoledronate and Docetaxel Therapy on Breast Cancer Colonization of Three-Dimensional Osteoblastic Tissue
Area of Honors:
Bioengineering
Keywords:
breast cancer
bone metastasis
bisphosphonate
File:
Download Miller_Genevieve_Honors_Thesis_2010.pdf
Thesis Supervisors:
Erwin A Vogler, Thesis Supervisor
Erwin A Vogler, Thesis Supervisor
Andrea Marie Mastro, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor

9. Preliminary investigation of the effects of arch height on subtalar joint mechanics during walking

open_access
Open Access
Author:
O'Kelly, Katherine Kristen
Title:
Preliminary investigation of the effects of arch height on subtalar joint mechanics during walking
Area of Honors:
Bioengineering
Keywords:
subtalar joint
walking
arch height
ankle
mechanics
File:
Download Honors_Thesis_-_Katherine_K._OKelly.pdf
Thesis Supervisors:
Stephen Jacob Piazza, Thesis Supervisor
Stephen Jacob Piazza, Thesis Supervisor
Peter J Butler, Thesis Honors Advisor
Jinger S. Gottschall, Faculty Reader

10. PARTICLE SORTING WITH SURFACE ACOUSTIC WAVES (SAW) FOR A FULLY INTEGRATED MICROFLUIDIC FLOW CYTOMETER

open_access
Open Access
Author:
Pisupati, Karthik
Title:
PARTICLE SORTING WITH SURFACE ACOUSTIC WAVES (SAW) FOR A FULLY INTEGRATED MICROFLUIDIC FLOW CYTOMETER
Area of Honors:
Bioengineering
Keywords:
microfluidic
surface acoustic wave
sorting
File:
Download karthikpisupati_thesis.pdf
Thesis Supervisors:
Jun Huang, Thesis Supervisor
Jun Huang, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Siyang Zheng, Faculty Reader

11. Improving Carbon Fiber Microelectrode Performance for Measuring Serotonin by Voltammetry

open_access
Open Access
Author:
Sawarynski, Lauren Elizabeth
Title:
Improving Carbon Fiber Microelectrode Performance for Measuring Serotonin by Voltammetry
Area of Honors:
Bioengineering
Keywords:
serotonin
carbon fiber microelectrodes
voltammetry
File:
Download LSawarynski_FinalThesis.pdf
Thesis Supervisors:
Dr. Anne Milasincic Andrews, Ph D, Thesis Supervisor
Dr. Anne Milasincic Andrews, Ph D, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Peter J Butler, Faculty Reader

13. AORTIC OUTLET EXTENSION IN THE 12CC PENN STATE PEDIATRIC VENTRICULAR ASSIST DEVICE

open_access
Open Access
Author:
Fickes, Michael Glenn
Title:
AORTIC OUTLET EXTENSION IN THE 12CC PENN STATE PEDIATRIC VENTRICULAR ASSIST DEVICE
Area of Honors:
Bioengineering
Keywords:
outlet valve extension
blockage
PVAD
File:
Download Michael_Fickes_Honors_Thesis_Schreyers.pdf
Thesis Supervisors:
Keefe B Manning, Thesis Supervisor
Dr. Keefe B Manning, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Steven Deutsch, Faculty Reader

14. The Challenges of Implanting the Penn State Pediatric Ventricular Assist Device: Study of the Ascending Aorta Anastomotic Flow

open_access
Open Access
Author:
Perone, Michael Vincent
Title:
The Challenges of Implanting the Penn State Pediatric Ventricular Assist Device: Study of the Ascending Aorta Anastomotic Flow
Area of Honors:
Bioengineering
Keywords:
Penn State PVAD
anastomosis
File:
Download Perone_-_Honors_Thesis.pdf
Thesis Supervisors:
Keefe B Manning, Thesis Supervisor
Dr. Keefe B Manning, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Steven Deutsch, Faculty Reader

15. THE EFFECTS OF MULTIPLE KINESIN MOTORS ON CARGO TRANSPORT VELOCITY

open_access
Open Access
Author:
Bizzaro, Nicholas Robert
Title:
THE EFFECTS OF MULTIPLE KINESIN MOTORS ON CARGO TRANSPORT VELOCITY
Area of Honors:
Bioengineering
Keywords:
motor proteins
kinesin
cellular transport
File:
Download Schreyer_Honors_College_Thesis_-_Nicholas_Bizzaro.pdf
Thesis Supervisors:
Dr. William O Hancock, Thesis Supervisor
Dr. William O Hancock, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Peter J Butler, Faculty Reader
Margaret June Slattery, Faculty Reader

16. THE CHARACTERIZATION OF A MICROCHANNEL DEVICE USING LASER BASED MICRO-PIV

open_access
Open Access
Author:
Wang , Sicong
Title:
THE CHARACTERIZATION OF A MICROCHANNEL DEVICE USING LASER BASED MICRO-PIV
Area of Honors:
Bioengineering
Keywords:
microchannel
microfluidics
micro-PIV
soft lithography
murray law
circulating tumor cell
velocity profile
volumetric flow rate
pulastive flow
PDMS
File:
Download THECHARACTERIZATION_OF_MICROCHANNEL_DEVICE_USING_LASER_BASEDMICROPIV.pdf
Thesis Supervisors:
Siyang Zheng, Thesis Supervisor
Siyang Zheng, Thesis Supervisor
Peter J Butler, Thesis Honors Advisor
Dr. William O Hancock, Faculty Reader

17. DEVELOPMENT AND CHARACTERIZATION OF EXTRACELLULAR AND INTRACELLULAR TARGETS IN TUMOR-INDUCED ENDOTHELIAL JUNCTION REGULATIONS

open_access
Open Access
Author:
Yunkunis, Tara Marie
Title:
DEVELOPMENT AND CHARACTERIZATION OF EXTRACELLULAR AND INTRACELLULAR TARGETS IN TUMOR-INDUCED ENDOTHELIAL JUNCTION REGULATIONS
Area of Honors:
Bioengineering
Keywords:
signaling
VE-cadherin
calcium
File:
Download Yunkunis_Thesis_SHC_FINAL.pdf
Thesis Supervisors:
Cheng Dong, Thesis Supervisor
Cheng Dong, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor

18. Modeling the Roll-Slip Nonlinear Dynamics of the Knee

open_access
Open Access
Author:
Gagliardi, Virginia Marie
Title:
Modeling the Roll-Slip Nonlinear Dynamics of the Knee
Area of Honors:
Bioengineering
Keywords:
knee
knee joint
prosthetics
dynamics of the knee
roll-slide
roll-slip
oscillator
File:
Download Gagliardi_Thesis_Spring_2010.pdf
Thesis Supervisors:
Joseph Paul Cusumano, Thesis Supervisor
Joseph Paul Cusumano, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Margaret June Slattery, Faculty Reader

19. A Foundational Study Of Heart Valve Tissue Engineering: exploration of Natural and Synthetic Scaffold Approaches

open_access
Open Access
Author:
Johnson, Katherine Lynn
Title:
A Foundational Study Of Heart Valve Tissue Engineering: exploration of Natural and Synthetic Scaffold Approaches
Area of Honors:
Bioengineering
Keywords:
Tissue engineering
Bioengineering
heart valve
File:
Download Johnson_Katherine_heartvalvetissue.pdf
Thesis Supervisors:
Dr. George Engelmayr, Thesis Supervisor
Peter J Butler, Thesis Honors Advisor
Margaret June Slattery, Faculty Reader

20. The effect of bioconjugation of calcium phosphosilicate nanoparticles on breast cancer cell association under shear conditions

open_access
Open Access
Author:
Harter, Lauren Michele
Title:
The effect of bioconjugation of calcium phosphosilicate nanoparticles on breast cancer cell association under shear conditions
Area of Honors:
Bioengineering
Keywords:
nanoparticles
breast cancer
shear conditions
File:
Download Harter_Lauren_bioconjugationCPSNPsbreastcancer.pdf
Thesis Supervisors:
Cheng Dong, Thesis Supervisor
Peter J Butler, Thesis Honors Advisor

21. An In Vitro Fluid Dynamic Study of a Continuous Flow Device Outlet in Relation to Acquired von Willebrand Syndrome

open_access
Open Access
Author:
Lani, Ryan Anthony
Title:
An In Vitro Fluid Dynamic Study of a Continuous Flow Device Outlet in Relation to Acquired von Willebrand Syndrome
Area of Honors:
Bioengineering
Keywords:
laser Doppler velocimetry (LDV)
HeartMate II
von Willebrand factor (vWF)
ventricular assist devices (VAD)
fluid dynamics
File:
Download Lani_Ryan_An_In_Vitro_Fluid_Dynamic_Study_of_a_Continuous_Flow_Device.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Peter J Butler, Thesis Honors Advisor
Steven Deutsch, Faculty Reader

22. Magnetic Resonance Imaging as a Diagnostic Tool in the Detection of Diabetic Retinopathy in Mice

open_access
Open Access
Author:
Hobelmann, Kealan Christian
Title:
Magnetic Resonance Imaging as a Diagnostic Tool in the Detection of Diabetic Retinopathy in Mice
Area of Honors:
Bioengineering
Keywords:
MRI
diabetic retinopathy
diabetes
radiofrequency coil
magnetic resonance imaging
File:
Download 1-Hobelmann_Kealan_DiabeticRetinopathyMRI.pdf
Thesis Supervisors:
Thomas Neuberger, Thesis Supervisor
Peter J Butler, Thesis Honors Advisor

25. The Use of Time Correlated Single Photon Counting to Optimize siRNA Encapsulation in Nanoliposomes

open_access
Open Access
Author:
Tanella, Elaine Marie
Title:
The Use of Time Correlated Single Photon Counting to Optimize siRNA Encapsulation in Nanoliposomes
Area of Honors:
Bioengineering
Keywords:
siRNA
nanoliposome
molecular brightness
time correlated single photon counting
fluorescence correlation spectroscopy
File:
Download Elaine_Tanella_thesis.pdf
Thesis Supervisors:
Peter J Butler, Thesis Supervisor
Peter J Butler, Thesis Honors Advisor
Margaret June Slattery, Faculty Reader

27. Feasibility Studies for Optical Trap Detection of Single Molecule Adhesion and Force Generation

open_access
Open Access
Author:
Bernick, David J
Title:
Feasibility Studies for Optical Trap Detection of Single Molecule Adhesion and Force Generation
Area of Honors:
Bioengineering
Keywords:
optical trap
laser tweezers
integrin ligand binding
bead
avidin
biotin
microscopy
File:
Download Final_Thesis_Bernick_David_Optical_Trap.pdf
Thesis Supervisors:
Peter J Butler, Thesis Supervisor
Peter J Butler, Thesis Honors Advisor
Dr. Keefe B Manning, Faculty Reader
Dr. William O Hancock, Faculty Reader

29. Preliminary Study into Visualization Modalities of von Willebrand Proteolysis in Response to Applied Shear

open_access
Open Access
Author:
Scanlon, Matthew P
Title:
Preliminary Study into Visualization Modalities of von Willebrand Proteolysis in Response to Applied Shear
Area of Honors:
Bioengineering
Keywords:
von Willebrand Factor
vWF
proteolysis
ventricular assist device
cardiovascular disease
visualization
fluorescence
File:
Download Scanlon_Thesis.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Peter J Butler, Thesis Honors Advisor
Steven Deutsch, Faculty Reader

32. A correlative study of fluid mechanics and evidence of thrombus formation within the Penn State 50 cc V-2 left ventricular assist device

open_access
Open Access
Author:
Topper, Stephen Robert
Title:
A correlative study of fluid mechanics and evidence of thrombus formation within the Penn State 50 cc V-2 left ventricular assist device
Area of Honors:
Bioengineering
Keywords:
ventricular assist device
thrombosis
fluid dynamics
pulsatile
wall shear
surface evaluation
particle image velocimetry
File:
Download Topper_Stephen_Schreyer_Honors_Thesis_2012.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Peter J Butler, Thesis Honors Advisor
Steven Deutsch, Faculty Reader

33. Design By Example: a Web-based Tool for Context-driven Design of Biomedical Devices

open_access
Open Access
Author:
Dzombak, Rachel Victoria
Title:
Design By Example: a Web-based Tool for Context-driven Design of Biomedical Devices
Area of Honors:
Bioengineering
Keywords:
medical devices
developing countries
context
design
bioengineering
africa
Kenya
File:
Download Dzombak_Rachel_DesignByExample_Final.pdf
Thesis Supervisors:
Peter J Butler, Thesis Honors Advisor
Peter J Butler, Thesis Supervisor
Khanjan Mehta, Faculty Reader
Margaret June Slattery, Faculty Reader

34. Finite Element Analysis of Microfabricated Poly(Glycerol Sebacate) Scaffolds for use in Heart Valve Tissue Engineering

open_access
Open Access
Author:
Chowdhury, Surjyanil
Title:
Finite Element Analysis of Microfabricated Poly(Glycerol Sebacate) Scaffolds for use in Heart Valve Tissue Engineering
Area of Honors:
Bioengineering
Keywords:
Chowdhury
finite element
COMSOL
heart valve
tissue engineering
poly glycerol sebacate
PGS
microfabricate
scaffold
mesh
File:
Download honors_thesis_final_draft.pdf
Thesis Supervisors:
Dr. William O Hancock, Thesis Supervisor
Peter J Butler, Thesis Honors Advisor
Dr. Keefe B Manning, Faculty Reader

35. Independent On-line Information Processing in Bimanual Coordinated Movements

open_access
Open Access
Author:
Waltz, Lauren Ann
Title:
Independent On-line Information Processing in Bimanual Coordinated Movements
Area of Honors:
Bioengineering
Keywords:
motor control
bimanual coordination
File:
Download Waltz_Lauren_IndependentOnLineInformationProcessing.pdf
Thesis Supervisors:
Robert L Sainburg, Thesis Supervisor
Andrzej Przybyla, Thesis Supervisor
Peter J Butler, Thesis Honors Advisor
Stephen Jacob Piazza, Faculty Reader

36. The effect of substrate stiffness on fibrillin expression by mouse embryonic fibroblasts (MEFs)

open_access
Open Access
Author:
Sheldrake, Anne E
Title:
The effect of substrate stiffness on fibrillin expression by mouse embryonic fibroblasts (MEFs)
Area of Honors:
Bioengineering
Keywords:
MEFs
tissue engineering
cardiac
acrylamide
bisacrylamide
heart
fibrillin
scar tissue
File:
Download sheldrake_anne_effect_of_susbstrate_stiffness.pdf
Thesis Supervisors:
Dr. Justin Lee Brown, Thesis Supervisor
Peter J Butler, Thesis Honors Advisor
Dr. William O Hancock, Faculty Reader

40. The Effects of Hematocrit and Rotation Time on Platelet Adhesion to a Polyurethane Urea Surface

open_access
Open Access
Author:
Grunenwald, Lauren Elizabeth
Title:
The Effects of Hematocrit and Rotation Time on Platelet Adhesion to a Polyurethane Urea Surface
Area of Honors:
Bioengineering
Keywords:
platelet adhesion
rotating disk
polyurethane urea
File:
Download LaurenGrunenwaldThesis-HonorsFinal.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Dr. Keefe B Manning, Thesis Honors Advisor
Margaret June Slattery, Faculty Reader
Christopher Alan Siedlecki, Faculty Reader

42. Encapsulation of Docetaxel in Calcium Phosphosilicate Nanoparticles and the Effects of Bioconjugation

open_access
Open Access
Author:
Hughes, Kelly E
Title:
Encapsulation of Docetaxel in Calcium Phosphosilicate Nanoparticles and the Effects of Bioconjugation
Area of Honors:
Bioengineering
Keywords:
nanoparticles
breast cancer
cancer
calcium phosphate
File:
Download Hughes_Honors_Thesis.pdf
Thesis Supervisors:
Cheng Dong, Thesis Supervisor
James Hansell Adair, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor

44. An In Vitro Investigation of the Effect of Shear on von Willebrand Factor Proteolysis

open_access
Open Access
Author:
Burke, Shannon Leigh
Title:
An In Vitro Investigation of the Effect of Shear on von Willebrand Factor Proteolysis
Area of Honors:
Bioengineering
Keywords:
von Willebrand factor
vWF
ventricular assist device
VAD
proteolysis
heart failure
cardiovascular disease
File:
Download Shannon_Burke_-_Thesis.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Dr. Keefe B Manning, Thesis Honors Advisor
Dr. William O Hancock, Faculty Reader
Margaret June Slattery, Faculty Reader

46. Fluid Dynamic Studies of a Porcine Aortic Valve in Preparation for Future Living Tissue Valve Studies

open_access
Open Access
Author:
Schmiech, Kathryn Victoria
Title:
Fluid Dynamic Studies of a Porcine Aortic Valve in Preparation for Future Living Tissue Valve Studies
Area of Honors:
Bioengineering
Keywords:
aortic valve
fluid dynamics
porcine valve
particle image velocimetry
File:
Download KSchmiechFinalThesis.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Peter J Butler, Faculty Reader

47. Investigating the Mechanics of Cancer Cell Membranes Using Microfluidics

open_access
Open Access
Author:
Ramadi, Khalil Basil
Title:
Investigating the Mechanics of Cancer Cell Membranes Using Microfluidics
Area of Honors:
Bioengineering
Keywords:
Cancer
CTC
Isolation
Characterization
Tumor
Membrane
Mechanics
Cell
Expansion
Osmosis
Microfluidics
Viscoelasticity
File:
Download Thesis_Final_final_v2.pdf
Thesis Supervisors:
Siyang Zheng, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Peter J Butler, Faculty Reader

48. Effects of Synonymous, Consecutive, Repetitive Codons on Bacterial Translation Elongation Rates

open_access
Open Access
Author:
Heasley, Victoria Lynn
Title:
Effects of Synonymous, Consecutive, Repetitive Codons on Bacterial Translation Elongation Rates
Area of Honors:
Bioengineering
Keywords:
repetitive codon sequences elongation
affects on translation elongation rates
synthetic biology
genetic engineering
File:
Download Heasley_Victoria__Effects_of_Repetitive_Codons_on_Elongation.pdf
Thesis Supervisors:
Howard M Salis, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Peter J Butler, Faculty Reader

49. Jaipur Foot Project: Computer Simulation for Determination of Static and Cyclic Stresses

open_access
Open Access
Author:
Somers, Sarah Marie
Title:
Jaipur Foot Project: Computer Simulation for Determination of Static and Cyclic Stresses
Area of Honors:
Bioengineering
Keywords:
Jaipur Foot
cyclic stress
fatigue life
prosthetic
File:
Download Somers_Sarah_Jaipur_Foot_Project.pdfDownload Somers_Sarah_JaipurMovie.avi
Thesis Supervisors:
Margaret June Slattery, Thesis Supervisor
Peter J Butler, Thesis Honors Advisor
Elizabeth Cunningham Kisenwether, Faculty Reader

50. The Effect of Blood on Circulating Tumor Cells' Expression of Epithelial and Mesenchymal Cell Markers

open_access
Open Access
Author:
Clabbers, Andrea Laurie
Title:
The Effect of Blood on Circulating Tumor Cells' Expression of Epithelial and Mesenchymal Cell Markers
Area of Honors:
Bioengineering
Keywords:
Circulating Tumor Cells
EpCAM
Epithelial to Mesenchymal Transition
File:
Download Andrea_Clabbers_Thesis_Final.pdf
Thesis Supervisors:
Siyang Zheng, Thesis Supervisor
Sheereen Majd, Thesis Honors Advisor
Dr. William O Hancock, Faculty Reader

51. The Effect of Consumption of the Probiotic Bifidobacterium Animalis Subspecies Lactis (BB-12) on Function and Phenotype of Natural Killer Cells

open_access
Open Access
Author:
Krisher, Sarah Yelena
Title:
The Effect of Consumption of the Probiotic Bifidobacterium Animalis Subspecies Lactis (BB-12) on Function and Phenotype of Natural Killer Cells
Area of Honors:
Bioengineering
Keywords:
probiotics
BB-12
natural killer cells
File:
Download Sarah_Krisher__Final_Thesis_Submission.pdf
Thesis Supervisors:
Connie Jo Rogers, Thesis Supervisor
Sheereen Majd, Thesis Honors Advisor
Dr. William O Hancock, Faculty Reader

52. An Experimental Setup to Test the Effects of Shear Stress on von Willebrand Factor

open_access
Open Access
Author:
Corsetti, Monica Claire
Title:
An Experimental Setup to Test the Effects of Shear Stress on von Willebrand Factor
Area of Honors:
Bioengineering
Keywords:
von Willebrand Factor
vWF
Optical Trap
Optical Tweezers
Shear Stress
Acquired von Willebrand Syndrome
ADAMTS-13
File:
Download Thesis_Monica_Corsetti.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Peter J Butler, Faculty Reader
Dr. William O Hancock, Faculty Reader
Dr. Keefe B Manning, Thesis Honors Advisor

53. Nanofiber Control of Focal Adhesion Dynamics and Cell Migration for Regenerative Medicine

open_access
Open Access
Author:
Riley, Thomas Roberts
Title:
Nanofiber Control of Focal Adhesion Dynamics and Cell Migration for Regenerative Medicine
Area of Honors:
Bioengineering
Keywords:
Matlab
Image Processing
Focal Adhesion
Cell Migration
Nanofiber
Tissue Engineering
Regenerative Medicine
FAITS
File:
Download RileyThesisFinalDraft.pdf
Thesis Supervisors:
Dr. Justin Lee Brown, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Peter J Butler, Faculty Reader

54. In Vitro and Computational Analysis of the Fluid Mechanics Promoting Thrombus Formation in a Backward-facing Step Flow Domain

open_access
Open Access
Author:
Witmer, Kory P
Title:
In Vitro and Computational Analysis of the Fluid Mechanics Promoting Thrombus Formation in a Backward-facing Step Flow Domain
Area of Honors:
Bioengineering
Keywords:
thrombosis
fluid mechanics
computational fluid dynamics
cardiovascular devices
magnetic resonance imaging
File:
Download Schreyer_FinalThesis_Witmer_Kory.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Dr. Keefe B Manning, Thesis Honors Advisor
Dr. William O Hancock, Faculty Reader

55. Histological Analysis of in vitro Thrombus Formation in a Backward Facing Step Flow Domain Using Carstairs' Stain

open_access
Open Access
Author:
Kinney, Joanna E
Title:
Histological Analysis of in vitro Thrombus Formation in a Backward Facing Step Flow Domain Using Carstairs' Stain
Area of Honors:
Bioengineering
Keywords:
thrombosis
histology
bioengineering
heart
blood
File:
Download Kinney_Joanna_Thesis_Final.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Peter J Butler, Faculty Reader

56. A Fluid Dynamic Study of the Effect of Hematocrit in the 12 cc Penn State Pediatric Ventricular Assist Device

open_access
Open Access
Author:
Silver, Jeremy Michael
Title:
A Fluid Dynamic Study of the Effect of Hematocrit in the 12 cc Penn State Pediatric Ventricular Assist Device
Area of Honors:
Bioengineering
Keywords:
ventricular assist device
pediatric
cardiovascular device
hematocrit
thrombosis
particle image velocimetry
piv
VAD
PVAD
File:
Download Silver_SHC_Thesis_FINAL.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Dr. Keefe B Manning, Thesis Honors Advisor
Dr. William O Hancock, Faculty Reader
Peter J Butler, Faculty Reader

57. Localized Thrombus Rheology: A Study Through the Development of a Magnetic Bead Microrheometry System

open_access
Open Access
Author:
Nilkant, Prithvi
Title:
Localized Thrombus Rheology: A Study Through the Development of a Magnetic Bead Microrheometry System
Area of Honors:
Bioengineering
Keywords:
thrombus
blood clot
rheology
elasticity
File:
Download Prithvi_Nilkant_Localized_Thrombus_Rheology_-_A_Study_Through_the_Development_of_a_Magnetic_Bead_Microrheometry_System.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Dr. Keefe B Manning, Thesis Honors Advisor
Peter J Butler, Faculty Reader
Margaret June Slattery, Faculty Reader

58. Single-molecule microscopy step detection algorithms: kinesin motor proteins and the cellulose synthesis complex

open_access
Open Access
Author:
Deffenbaugh, Nathan C
Title:
Single-molecule microscopy step detection algorithms: kinesin motor proteins and the cellulose synthesis complex
Area of Honors:
Bioengineering
Keywords:
kinesin
motor proteins
step detection
single-molecule
cellulose synthesis complex
hidden Markov model
File:
Download DeffenbaughNathan_SHCThesis_May2015.pdf
Thesis Supervisors:
Dr. William O Hancock, Thesis Supervisor
Peter J Butler, Faculty Reader
Dr. Justin Lee Brown, Faculty Reader
Dr. William O Hancock, Thesis Honors Advisor

59. Protocol and Initial Surface Analysis of Explanted Blood Sacs for the Penn State Pediatric Ventricular Assist Device

open_access
Open Access
Author:
Ceneviva, Nicholas E
Title:
Protocol and Initial Surface Analysis of Explanted Blood Sacs for the Penn State Pediatric Ventricular Assist Device
Area of Honors:
Bioengineering
Keywords:
ventricular assist device
pediatric
cardiovascular device
thrombosis
VAD
PVAD
optical profilometry
File:
Download Ceneviva_Nicholas_SHCThesisFinal.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Dr. Keefe B Manning, Thesis Honors Advisor
William Joseph Weiss, Faculty Reader

60. A Comparative Study of the Anatomy and Functional Morphology of the Mammalian Nasal Cavity

open_access
Open Access
Author:
Quigley, Andrew Patrick
Title:
A Comparative Study of the Anatomy and Functional Morphology of the Mammalian Nasal Cavity
Area of Honors:
Bioengineering
Keywords:
mammal
nasal airway
three-dimensional anatomy
reconstruction
morphometry
magnetic resonance imaging
olfaction
respiration
File:
Download Quigley_Thesis_Final_SHC.pdf
Thesis Supervisors:
Brent A Craven, Thesis Supervisor
Michael H Krane, Thesis Supervisor
Sheereen Majd, Thesis Honors Advisor

62. Exploiting Biomarkers Assists in Degradation of Breast Cancer Cells and Reduces Extravasation

open_access
Open Access
Author:
Zaki, Peter Maged
Title:
Exploiting Biomarkers Assists in Degradation of Breast Cancer Cells and Reduces Extravasation
Area of Honors:
Bioengineering
Keywords:
breast cancer
pancreatic cancer
melanoma
nanoparticles
nanoliposomes
docetaxel
ceramide
CD71
CD44
metastasis
File:
Download Thesis_Final.pdf
Thesis Supervisors:
Cheng Dong, Thesis Supervisor
James Hansell Adair, Thesis Supervisor
Peter J Butler, Thesis Honors Advisor

63. A Study in the Design of an Accelerated Wear Tester that is Compatible with a Particle Image Velocimetry and High Speed Camera Setup

open_access
Open Access
Author:
Brown, Edward Alexander
Title:
A Study in the Design of an Accelerated Wear Tester that is Compatible with a Particle Image Velocimetry and High Speed Camera Setup
Area of Honors:
Bioengineering
Keywords:
Accelerated Wear Tester
Particle Image Velocimetry
AWT
PIV
Heart Valve
Artificial Heart Valve
Fluid Dynamics
File:
Download Edward_A_Brown_Honors_Thesis.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Dr. Keefe B Manning, Thesis Honors Advisor
Dr. William O Hancock, Faculty Reader

64. Development of A Multi-layered Micro-patterned Electrospun Mesh for Hernia Repair

open_access
Open Access
Author:
Orr, Sara A
Title:
Development of A Multi-layered Micro-patterned Electrospun Mesh for Hernia Repair
Area of Honors:
Bioengineering
Keywords:
electrospin
electrospun
hernia
mesh
File:
Download 1-Orr_Sara_TheDevelopmentofAMultiLayeredMicroPatternedElectrospunMeshforHerniaRepair.pdf
Thesis Supervisors:
Jian Yang, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Yong Wang, Faculty Reader

65. Modeling the Bidirectional Transport of Intracellular Cargos by Oppositely-directed Motor Proteins

open_access
Open Access
Author:
Mentley, Brandon Scott
Title:
Modeling the Bidirectional Transport of Intracellular Cargos by Oppositely-directed Motor Proteins
Area of Honors:
Bioengineering
Keywords:
kinesin
dynein
motor protein
bidirectional transport
matlab
simulation
File:
Download Brandon_Mentley_-_Thesis_Final_Fall15.pdf
Thesis Supervisors:
Dr. William O Hancock, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
John Fricks, Faculty Reader

66. THE EFFECTS OF BIOCONJUGATION OF CALCIUM PHOSPHOSILICATE NANOPARTICLES ON THE DELIVERY TO BREAST CANCER CELLS

open_access
Open Access
Author:
Gonzalez, Virginia Laura
Title:
THE EFFECTS OF BIOCONJUGATION OF CALCIUM PHOSPHOSILICATE NANOPARTICLES ON THE DELIVERY TO BREAST CANCER CELLS
Area of Honors:
Bioengineering
Keywords:
Calcium Phosphosilicate
Nanoparticles
Breast Cancer
Transendothelial Migration
File:
Download Honors_Thesis_VLG.pdf
Thesis Supervisors:
Cheng Dong, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor

67. β-Catenin Signaling Leading to the Maintenance and Differentiation of MC3T3 Cells in Response to Electrospun Nanofibers

open_access
Open Access
Author:
Nagurney, Rebecca Ann
Title:
β-Catenin Signaling Leading to the Maintenance and Differentiation of MC3T3 Cells in Response to Electrospun Nanofibers
Area of Honors:
Bioengineering
Keywords:
Nanofibers
Electrospinning
PMMA
PolyHEMA
Polyvinyl Alcohol
Beta-Catenin
Osteogenesis
File:
Download Nagurney_FinalThesis_BIOE_2016.pdf
Thesis Supervisors:
Dr. Justin Lee Brown, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor

68. Factors Impacting the Efficacy of Cell-mediated Drug Delivery to the Brain via the Blood Brain Barrier

open_access
Open Access
Author:
Selvi, Erhan Yavuz
Title:
Factors Impacting the Efficacy of Cell-mediated Drug Delivery to the Brain via the Blood Brain Barrier
Area of Honors:
Bioengineering
Keywords:
cell-mediated drug delivery
blood brain barrier
VE-cadherin
VCAM-1
ICAM-1
VLA-4
LFA-1
transendothelial migration
File:
Download SCHREYER_THESIS_4.11.16_final.pdf
Thesis Supervisors:
Cheng Dong, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Dr. Justin Lee Brown, Faculty Reader

69. Computational Modeling of the Effects of Shear Stress on von Willebrand Factor Proteolysis

open_access
Open Access
Author:
Tramontozzi, Michael William
Title:
Computational Modeling of the Effects of Shear Stress on von Willebrand Factor Proteolysis
Area of Honors:
Bioengineering
Keywords:
Biomedical
Engineering
COMSOL
von Willebrand Factor
Ventricular Assist Device
Computational
Optical Trap
Shear
File:
Download Michael_Tramontozzi_-_Thesis_Final.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Dr. Keefe B Manning, Thesis Honors Advisor
Peter J Butler, Faculty Reader
Margaret June Slattery, Faculty Reader

70. The Investigation of Fluid Shear Stress and Subsequent Conformational Changes of von Willebrand Factor Observed in an Optical Trap

open_access
Open Access
Author:
Candela, Xavier Joseph
Title:
The Investigation of Fluid Shear Stress and Subsequent Conformational Changes of von Willebrand Factor Observed in an Optical Trap
Area of Honors:
Bioengineering
Keywords:
vWF
optical trap
fluid shear
von Willebrand Factor
LVADs
File:
Download FORMATTED_CANDELA_THESIS_PC_version_CORRECT.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Dr. Keefe B Manning, Thesis Honors Advisor
Peter J Butler, Faculty Reader

71. Comparing Novel Techniques for Measuring the Bending Modulus of Lipid Bilayer Membranes in Erythrocytes

open_access
Open Access
Author:
Frazzette, Nicholas James
Title:
Comparing Novel Techniques for Measuring the Bending Modulus of Lipid Bilayer Membranes in Erythrocytes
Area of Honors:
Bioengineering
Keywords:
mechanobiology
bending modulus
mechanotransduction
lipid bilayers
membrane bending
erythrocytes
TCSPC
fluorescence
File:
Download Frazzette_SHC_Thesis_v4.pdf
Thesis Supervisors:
Peter J Butler, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Herbert Herling Lipowsky, Faculty Reader

73. Characterizing Melanoma Adhesion Dynamics: Thrombin Mediated Interactions and Polymorphic Neutrophil Deformability

open_access
Open Access
Author:
Lee, Deborah Snyder
Title:
Characterizing Melanoma Adhesion Dynamics: Thrombin Mediated Interactions and Polymorphic Neutrophil Deformability
Area of Honors:
Bioengineering
Keywords:
melanoma
polymorphic neutrophils
cellular adhesions
flow assays
bioengineering
cancer
thrombin
fibrin
endothelium
File:
Download undergraduate_thesis_deborah_lee_FINAL.pdf
Thesis Supervisors:
Cheng Dong, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Yong Wang, Faculty Reader