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201. Clinically Irrelevant Concentrations of Kinase Inhibitors Contribute to Failure of Drug Repurposing Efforts in Clinical Trials: a Meta-Analysis

open_access
Open Access
Author:
Shah, Anushka
Title:
Clinically Irrelevant Concentrations of Kinase Inhibitors Contribute to Failure of Drug Repurposing Efforts in Clinical Trials: a Meta-Analysis
Area of Honors:
Biology
Keywords:
clinical trials
repurposing
cancer
kinase inhibitors
meta-analysis
biology
in vitro
drug concentrations
File:
Download Shah_SHCThesis.pdf
Thesis Supervisors:
Justin R Pritchard, Thesis Supervisor
Richard W Ordway, Thesis Honors Advisor

202. Investigation of Striatal Astrocytes to GABAergic Neuron Conversion In Vivo in Huntington’s Disease Mouse Model

open_access
Open Access
Author:
Xu, Kevin
Title:
Investigation of Striatal Astrocytes to GABAergic Neuron Conversion In Vivo in Huntington’s Disease Mouse Model
Area of Honors:
Biology
Keywords:
ND1
Dlx2
Huntington's Disease
HD
GABAergic neurons
transcription factors
gene therapy
striatal astrocytes
R6/2 mouse model
astrocyte-to-neuron conversion
ND1
Dlx2
Huntington's Disease
HD
GABAergic neurons
transcription factors
gene therapy
striatal astrocytes
R6/2 mouse model
astrocyte-to-neuron conversion
File:
Download Xu_Kevin_Investigation_of_Striatal_Astrocytes_to_GABAergic_Neuron_Conversion_In_Vivo_in_Huntington_s_Disease_Mouse_Model.pdf
Thesis Supervisors:
Aimin Liu, Thesis Supervisor
Bernhard Luscher, Thesis Honors Advisor

203. Analyzing the evolution of the vaccine development process after the H1N1 Swine Flu Pandemic of 2009 to understand the process used to develop the COVID-19 vaccine

open_access
Open Access
Author:
Dahal, Sabina
Title:
Analyzing the evolution of the vaccine development process after the H1N1 Swine Flu Pandemic of 2009 to understand the process used to develop the COVID-19 vaccine
Area of Honors:
Biology
Keywords:
COVID-19
H1N1 Swine Flu of 2009
Influenza
Vaccine
Vaccine Development Process
Pandemic
mRNA vaccine
Evolution of Vaccine
File:
Download SabinaDahal_FinalThesis.pdf
Thesis Supervisors:
Nik Tsotakos, Thesis Supervisor
Sairam V Rudrabhatla, Thesis Honors Advisor

207. PFK-158 Increases Migration by Promoting Lipolysis and Fatty Acid Oxidation

open_access
Open Access
Author:
Bekker, Jennifer
Title:
PFK-158 Increases Migration by Promoting Lipolysis and Fatty Acid Oxidation
Area of Honors:
Biology
Keywords:
Epithelial-mesenchymal transition
EMT
PFK-158
metastasis
cell migration
cell proliferation
cancer cell metabolism
lipid metabolism
AMPK
HGF
File:
Download Bekker_Jennifer_PFK-158_Increases_Migration_by_Promoting_Lipolysis_and_Fatty_Acid_Oxidation.pdf
Thesis Supervisors:
Emily Sophia Bell, Thesis Supervisor
Michael Axtell, Thesis Honors Advisor

208. Determining the optimal substrate for the invasive New Zealand mud snail (Potamopyrgus antipodarum)

open_access
Open Access
Author:
Ghannam, Sally
Title:
Determining the optimal substrate for the invasive New Zealand mud snail (Potamopyrgus antipodarum)
Area of Honors:
Biology
Keywords:
New Zealand mud snail
Potamopyrgus antipodarum
invasive species
ecology
biology
periphyton
woody debris
leaf litter
Spirulina algae
optimal substrate
File:
Download Ghannam_Sally_Determining_the_Optimal_Substrate_for_the_Invasive_New_Zealand_Mud_Snail__Potamopyrgus_antipodarum_.pdf
Thesis Supervisors:
Edward P Levri, Thesis Supervisor
Laura Rotunno, Thesis Honors Advisor
Allison Cornell, Faculty Reader

209. Combinational Therapy for Acute Lymphoblastic Leukemia with Tyrosine Kinase Inhibitors and Bispecific T Cell Engagers In Vitro

open_access
Open Access
Author:
Shaffer, Mikayla
Title:
Combinational Therapy for Acute Lymphoblastic Leukemia with Tyrosine Kinase Inhibitors and Bispecific T Cell Engagers In Vitro
Area of Honors:
Biology
Keywords:
Acute Lymphoblastic Leukemia
Bispecific T Cell Engagers
Tyrosine Kinase Inhibitors
File:
Download Shaffer_Mikayla_Thesis_FINAL.pdf
Thesis Supervisors:
Cheng Dong, Thesis Supervisor
Timothy J Jegla, Thesis Honors Advisor
Justin R Pritchard, Thesis Supervisor

212. Using Artificial Intelligence to Recognize Wheat Stripe Rust Disease

open_access
Open Access
Author:
Singh, Vinay
Title:
Using Artificial Intelligence to Recognize Wheat Stripe Rust Disease
Area of Honors:
Biology
Keywords:
Artificial intelligence
Wheat stripe rust disease
Machine learning
Food insecurity
Climate change
Plant diseases
PlantVillage
File:
Download Singh_Vinay_Using_Artificial_Intelligence_to_Recognize_Wheat_Stripe_Rust_Disease.pdf
Thesis Supervisors:
David Hughes, Thesis Supervisor
Timothy J Jegla, Thesis Honors Advisor

213. Chromosome level genome assemblies of Drosophila pseudoobscura determine Cuernavaca sequence inversion breakpoints and rearrangement mechanisms

open_access
Open Access
Author:
Dutzman, Nicole
Title:
Chromosome level genome assemblies of Drosophila pseudoobscura determine Cuernavaca sequence inversion breakpoints and rearrangement mechanisms
Area of Honors:
Biology
Keywords:
Genetics
Drosophila pseudoobscura
Genome Assembly
Oxford Nanopore Sequencing
Chromosomal Inversions
Inversion Breakpoints
Cuernavaca
Heterozygosity
Repetitive Sequences
File:
Download Final_Thesis_Template.pdf
Thesis Supervisors:
Stephen Wade Schaeffer, Thesis Supervisor
Benoit A Dayrat, Thesis Honors Advisor

215. The Role of HDAC3 in Memory Updating via the Objects in Updated Locations (OUL) Task

open_access
Open Access
Author:
Wright, Destiny
Title:
The Role of HDAC3 in Memory Updating via the Objects in Updated Locations (OUL) Task
Area of Honors:
Biology
Keywords:
memory updating
aging
mice
memory reconsolidation
HDAC3
hippocampus
age-related cognitive decline
memory impairments
epigenetic mechanisms
File:
Download Destiny_Wright_Schreyer_Thesis_.pdf
Thesis Supervisors:
Janine Kwapis, Thesis Supervisor
Stephen Wade Schaeffer, Thesis Honors Advisor

216. A Measure of Platelet Activation and Aggregation Across Two Flow Regimes to Minimize Thromboembolic Events in Blood Pumps

open_access
Open Access
Author:
Sturgis, Hannah
Title:
A Measure of Platelet Activation and Aggregation Across Two Flow Regimes to Minimize Thromboembolic Events in Blood Pumps
Area of Honors:
Biology
Keywords:
thrombosis
flow cytometry
platelet activation
gel-filtered platelets
aggregation
File:
Download Sturgis_Hannah_thesis_FINAL.pdf
Thesis Supervisors:
Keefe B Manning, Thesis Supervisor
Benoit A Dayrat, Thesis Honors Advisor

217. A Longitudinal Analysis of Antibiotic Resistance in the Sediment Samples of the Delaware River Watershed and in the Clinical Infections in the Reading Hospital

open_access
Open Access
Author:
Sindhar, Safitaj
Title:
A Longitudinal Analysis of Antibiotic Resistance in the Sediment Samples of the Delaware River Watershed and in the Clinical Infections in the Reading Hospital
Area of Honors:
Biology
Keywords:
Antibiotic Resistance
Delaware River Watershed
Tetracycline
Ampicillin
Enterococcus
Escherichia coli
Polymerase Chain Reaction
DNA
Berks County
tet(A)
tet(R)
ctx
oxa
blaP
File:
Download Sindhar_Safitaj_LongitudinalAnalysisofAntibioticResistance.pdf
Thesis Supervisors:
Tami H Mysliwiec, Thesis Supervisor
Sandy Feinstein, Thesis Honors Advisor

218. Food Resilience in the Face of Catastrophic Global Events: Initial Computational Analysis of Nuclear Winter Scenarios on Rice

open_access
Open Access
Author:
Viswanathan, Vishnu
Title:
Food Resilience in the Face of Catastrophic Global Events: Initial Computational Analysis of Nuclear Winter Scenarios on Rice
Area of Honors:
Biology
Keywords:
nuclear
offset
genomics
rice
File:
Download Nuclear_Winter_Thesis_Revision_V2.pdf
Thesis Supervisors:
Jesse R Lasky, Thesis Supervisor
Stephen Wade Schaeffer, Thesis Honors Advisor

220. Cannabinoids as Neuroprotective Molecules in Photoreceptors following Light-Induced Retinal Degeneration in Zebrafish Retina

open_access
Open Access
Author:
Proano, Renata
Title:
Cannabinoids as Neuroprotective Molecules in Photoreceptors following Light-Induced Retinal Degeneration in Zebrafish Retina
Area of Honors:
Biology
Keywords:
cannabinoids
hemp
CBD
THC
Zebrafish
retina
age related macular degenaration
biology
therapeutic
neuroprotective
anti-inflammatory
rods
cones
photoreceptor
retinal degeneration
light-induced retinal degeneration
CB-13
novel therapy
immunofluorescence
animals
tissue preparation
cryosectioning
oxidative stress
endocannabinoid
receptors
model organism
File:
Download Renata_Proano_Thesis_Final_.pdf
Thesis Supervisors:
Salvatore Lucia Stella, Jr., Thesis Supervisor
Sairam V Rudrabhatla, Thesis Honors Advisor
Nik Tsotakos, Faculty Reader