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Start Over Area of Honors Biochemistry and Molecular Biology

154. Diffusion of Bacterial Quorum Sensing Molecules within the Squid Light Organ

open_access
Open Access
Author:
Yount, Taylor
Title:
Diffusion of Bacterial Quorum Sensing Molecules within the Squid Light Organ
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Quorum Sensing
Host-Microbe Symbiosis
Strain Diversity
Bacteria
Vibrio fischeri
Squid
Euprymna scolopes
Bioluminescence
File:
Download Taylor_Yount_Thesis.pdf
Thesis Supervisors:
Timothy Iwao Miyashiro, Thesis Supervisor
Santhosh Girirajan, Thesis Honors Advisor

156. Investigating the Role of FakA and FakB in Lipoprotein Biosynthesis in Staphylococcus aureus

open_access
Open Access
Author:
Hussain, Sheherbano
Title:
Investigating the Role of FakA and FakB in Lipoprotein Biosynthesis in Staphylococcus aureus
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
lipoproteins
FakA
FakB
staphylococcus aureus
TLR activity
acylation
TLR2/1
TLR2/6
fatty acids
File:
Download hussain_sheherbano.pdf
Thesis Supervisors:
Timothy Charles Meredith, Thesis Supervisor
Santhosh Girirajan, Thesis Honors Advisor

158. Identification and Characterization of trans-Translation Inhibitors

open_access
Open Access
Author:
Davison, Alexis
Title:
Identification and Characterization of trans-Translation Inhibitors
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
trans-translation
antibiotic resistance
ribosome profiling
KKL-4669
high-throughput screen
luciferase reporter assay
bacterial pathogens
Caulobacter
in vitro transcription/translation assay
File:
Download Davison_Alexis_Thesis_Sp2020.pdf
Thesis Supervisors:
Ken Keiler, Thesis Supervisor
Ying Gu, Thesis Honors Advisor

160. Designing Optimized Protein Molecular Weight Markers Applicable to both Coomassie Staining and Western Blotting

open_access
Open Access
Author:
Shibata, Yoshitaka Joey
Title:
Designing Optimized Protein Molecular Weight Markers Applicable to both Coomassie Staining and Western Blotting
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
protein molecular weight markers
SDS-PAGE
Western blotting
IgG antibody binding
polycistronic expression
protein expression
protein purification
File:
Download Shibata_Thesis_DesigningOptimizedProteinMWMarkers.pdf
Thesis Supervisors:
Song Tan, Thesis Supervisor
Wendy Hanna-Rose, Thesis Honors Advisor

161. Functional characterization of an ApiAP2 transcription factor in sexual development of Plasmodium falciparum

open_access
Open Access
Author:
Suhendra, Michelle
Title:
Functional characterization of an ApiAP2 transcription factor in sexual development of Plasmodium falciparum
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
malaria
gene regulation
transcription
transcription regulation
falciparum
plasmodium
apiap2
File:
Download Suhendra-thesis-final.pdf
Thesis Supervisors:
Manuel Llinas, Thesis Supervisor
Paul Babitzke, Thesis Honors Advisor

165. Comparative Analysis Between SARS-CoV, MERS-CoV, and SARS-CoV-2: Genomic Similarity, Spike Protein Homology, and Government Funding as it Relates to Vaccine Development

open_access
Open Access
Author:
Foresman, Bridget
Title:
Comparative Analysis Between SARS-CoV, MERS-CoV, and SARS-CoV-2: Genomic Similarity, Spike Protein Homology, and Government Funding as it Relates to Vaccine Development
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
SARS-CoV
SARS-CoV-2
Vaccine Development
MERS-CoV
Government Funding
NIH RePORTER
File:
Download BridgetForesman_FinalThesis.pdf
Thesis Supervisors:
Joel E Segel, Thesis Supervisor
Teh-Hui Kao, Thesis Honors Advisor

167. Investigation of The Biodegradation of Lipopolysaccharides by Bacillus spp Through ELISA and Polyacrylamide Gel Electrophoresis Silver Staining

open_access
Open Access
Author:
Dong, Shiwei
Title:
Investigation of The Biodegradation of Lipopolysaccharides by Bacillus spp Through ELISA and Polyacrylamide Gel Electrophoresis Silver Staining
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Lipopolysaccharides
Bacillus spp
Biodegradation of LPS
endotoxin
LPS
File:
Download Investigation_of_The_Biodegradation_of_Lipopolysaccharides_by_Bacillus_spp_Through_ELISA_and_Polyacrylamide_Gel_Electrophoresis_Silver_Staining.pdf
Thesis Supervisors:
Timothy Charles Meredith, Thesis Supervisor
Ming Tien, Thesis Honors Advisor

168. Studying the Role of Cyclin Dependent Kinase 5 (Cdk5) in Maintaining Healthy Neuronal Functions in Class I Dendritic Aborization Neurons of Drosophila

open_access
Open Access
Author:
Rudisill, Katelyn
Title:
Studying the Role of Cyclin Dependent Kinase 5 (Cdk5) in Maintaining Healthy Neuronal Functions in Class I Dendritic Aborization Neurons of Drosophila
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Drosophila
Microtubules
Biochemistry
Molecular Biology
Neurons
File:
Download Katelyn_Rudisill_Thesis.pdf
Thesis Supervisors:
Melissa Rolls, Thesis Supervisor
Song Tan, Thesis Honors Advisor

171. Investigating the molecular mechanisms of axon and dendrite regeneration in Drosophila peripheral neurons.

open_access
Open Access
Author:
Swope, Rachel
Title:
Investigating the molecular mechanisms of axon and dendrite regeneration in Drosophila peripheral neurons.
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
axon regeneration
dendrite regeneration
Drosophila melanogaster
Exocyst complex
endoplasmic reticulum
membrane
File:
Download thesis_FINAL_in_template.pdf
Thesis Supervisors:
Melissa Rolls, Thesis Supervisor
Ming Tien, Thesis Honors Advisor

176. Characterizing the Degradation of Cellulose by Combinations of Cellulolytic Enzymes

open_access
Open Access
Author:
Starr, Thomas
Title:
Characterizing the Degradation of Cellulose by Combinations of Cellulolytic Enzymes
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Biomass Conversion
Cellulases
Cellobiohyrdolases
Cellulose
Enzyme Synergy
Endoglucanases
File:
Download Thomas_Starr_Honors_Thesis_-_Final.pdf
Thesis Supervisors:
Charles T Anderson, Thesis Supervisor
Teh-Hui Kao, Thesis Honors Advisor

179. Characterizing the impacts of ornithine decarboxylase, spermidine synthase, and spermine synthase on polyamine pathway regulation and cell metabolism changes in Drosophila melanogaster

open_access
Open Access
Author:
Morales, Tahj
Title:
Characterizing the impacts of ornithine decarboxylase, spermidine synthase, and spermine synthase on polyamine pathway regulation and cell metabolism changes in Drosophila melanogaster
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Biochemistry
Polyamines
Drosophila Melanogaster
Metabolism
Ornithine decarboxylase
Spermidine synthase
Spermine synthase
Molecular Biology
File:
Download MoralesTahj_Thesis_Final.pdf
Thesis Supervisors:
Shannon Lyn Nowotarski, Thesis Supervisor
Sandy Feinstein, Thesis Honors Advisor

181. An Inside Look on Eutrophication in the Blue Marsh Reservoir by Identifying Cyanobacteria and Their Associated Toxin Genes: A Method to Use Cyanophages to Decrease Harmful Algal Blooms

open_access
Open Access
Author:
Moawad, Rana
Title:
An Inside Look on Eutrophication in the Blue Marsh Reservoir by Identifying Cyanobacteria and Their Associated Toxin Genes: A Method to Use Cyanophages to Decrease Harmful Algal Blooms
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
eutrophication
harmful algal blooms
cyanobacteria
Blue Marsh Reservoir
HABs
cyanophages
water quality
anthropogenic
File:
Download Moawad__Rana_Schreyer_Thesis_May_2022_FINAL_Complete_Submit_.pdf
Thesis Supervisors:
Tami H Mysliwiec, Thesis Supervisor
Sandy Feinstein, Thesis Honors Advisor

182. Exploring the Causes of Muscle Dysfunction Associated with Adenylosuccinate Lyase Deficiency in the Model Organism Caenorhabditis elegans

open_access
Open Access
Author:
Jan, Judy
Title:
Exploring the Causes of Muscle Dysfunction Associated with Adenylosuccinate Lyase Deficiency in the Model Organism Caenorhabditis elegans
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
C. elegans
Muscle Function
Adenylosuccinate Lyase Deficiency
Purine Metabolism
File:
Download Final_Thesis_Draft_Judy_Jan.pdf
Thesis Supervisors:
Wendy Hanna-Rose, Thesis Supervisor
David Scott Gilmour, Thesis Honors Advisor

185. Developing an in vitro Protease Assay for Determining the Transmembrane Topology of SARS-CoV-2 nsp6

open_access
Open Access
Author:
Nasal, Benjamin
Title:
Developing an in vitro Protease Assay for Determining the Transmembrane Topology of SARS-CoV-2 nsp6
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
SARS
COVID
coronavirus
protein topology
transmembrane
protease
microscopy
live cell imaging
western blotting
double membrane vesicle
File:
Download Schreyer_Thesis_FINAL_COPY.pdf
Thesis Supervisors:
Joyce Jose, Thesis Supervisor
Joseph C. Reese, Thesis Honors Advisor

187. The Properties and Location of Anisosome-Forming RNA-binding deficient TAR DNA-binding Protein 43 inside the Nucleus

open_access
Open Access
Author:
Mertick Sykes, Eli
Title:
The Properties and Location of Anisosome-Forming RNA-binding deficient TAR DNA-binding Protein 43 inside the Nucleus
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Protein
Liquid-Liquid Phase Separation
TDP-43
Mammalian Cells
Immunofluorescence
File:
Download Eli_Mertick-Sykes_Thesis_Final.pdf
Thesis Supervisors:
Xin Zhang, Thesis Supervisor
Song Tan, Thesis Honors Advisor

189. Use of Recombinant Urocanase to Study the Inhibitory Effects of Imidazolone Propionate Breakdown Products on Aspartate Aminotransferase

open_access
Open Access
Author:
Ruud, Isabella
Title:
Use of Recombinant Urocanase to Study the Inhibitory Effects of Imidazolone Propionate Breakdown Products on Aspartate Aminotransferase
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
aspartate aminotransferase
urocanase
histidine metabolism
enzyme inhibition
metabolic enzyme deficiencies
File:
Download IAR_Thesis_Final_PDF.pdf
Thesis Supervisors:
Allen T Phillips, Thesis Supervisor
Lorraine C Santy, Thesis Honors Advisor

190. Investigation into the HutD Protein within the Histidine Utilization (hut) Pathway in Pseudomonas putida

open_access
Open Access
Author:
Guzman, Nicholas
Title:
Investigation into the HutD Protein within the Histidine Utilization (hut) Pathway in Pseudomonas putida
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Histidine
Histidine Utilization Pathway (Hut)
HutC
HutD
repressor
promoter
operator
beta-galactosidase
pET vectors
Protein Overexpression
SDS-PAGE
Nickel-IMAC
Molecular Cloning
File:
Download Thesis_Final_Version_-_Guzman.pdf
Thesis Supervisors:
Joseph C. Reese, Thesis Supervisor
Allen T Phillips, Thesis Honors Advisor

192. Is there a Trade-off? Impacts of Antibiotic Treatments on Gut Microbiota and Immune Gene Expression in Honey Bees (Apis Mellifera)

open_access
Open Access
Author:
Tomasko, Nicholas
Title:
Is there a Trade-off? Impacts of Antibiotic Treatments on Gut Microbiota and Immune Gene Expression in Honey Bees (Apis Mellifera)
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Apis mellifera
Oxytetracycline
E. coli
Microbiome
Antimicrobial peptides
Immune genes
Immune response
File:
Download Tomasko_Nicholas_Final_Thesis.pdf
Thesis Supervisors:
Margarita Maria Lopez-Uribe, Thesis Supervisor
Joseph C. Reese, Thesis Honors Advisor

194. AHR Activation Affects Enteric Neuronal Survival by Inducing Apoptosis

open_access
Open Access
Author:
Kumar, Supriya
Title:
AHR Activation Affects Enteric Neuronal Survival by Inducing Apoptosis
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Aryl Hydrocarbon Receptor
TCDD
Enteric Nervous System
Persistant Organic Pollutant
Ceramide Synthesizing Genes
Apoptosis
Longitudinal Muscle Myenteric Plexus
Gut Motility
IM-FEN Cells
Neuronal Marker Genes
Nitrergic Neurons
Cholinergic Neurons
GI Tract
File:
Download Supriya_Kumar_Thesis_AHR_Activation_Affects_Enteric_Neuronal_Survival_by_Inducing_Apoptosis_.pdf
Thesis Supervisors:
Andrew Patterson, Thesis Supervisor
Joseph C. Reese, Thesis Honors Advisor

195. Assessing Sex Bias in Neurodevelopmental Disease-Associated Genes

open_access
Open Access
Author:
Scanlon, Bradley
Title:
Assessing Sex Bias in Neurodevelopmental Disease-Associated Genes
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
genetics
drosophila melanogaster
sex bias
neurodevelopmental diseases
genes
molecular biology
RNA interference
File:
Download Scanlon_Finalthesis.pdf
Thesis Supervisors:
Santhosh Girirajan, Thesis Supervisor
Santhosh Girirajan, Thesis Honors Advisor
Scott Brian Selleck, Faculty Reader

196. Topic Modeling as an Approach to Deduce Tissue-Specific Regions in the Human Genome

open_access
Open Access
Author:
Patel, Radha
Title:
Topic Modeling as an Approach to Deduce Tissue-Specific Regions in the Human Genome
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Topic Modeling
Transcription Factor Binding
Latent Dirichlet Allocation
Regulatory DNA Sequences
Tissue-Specific Regions
Human Genome
File:
Download final_draft_thesis.pdf
Thesis Supervisors:
Shaun Mahony, Thesis Supervisor
Santhosh Girirajan, Thesis Honors Advisor

197. Synthesis of Phosphatidylinositol 4,5-bisphosphate (PIP2) in Endosomal Compartments during Serum-Stimulated Cell Signaling

open_access
Open Access
Author:
Lee, Ellen
Title:
Synthesis of Phosphatidylinositol 4,5-bisphosphate (PIP2) in Endosomal Compartments during Serum-Stimulated Cell Signaling
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
integrin recycling
epithelial cell migration
cancer
endosomes
File:
Download Lee_Ellen_Thesis2.pdf
Thesis Supervisors:
Lorraine C Santy, Thesis Supervisor
Song Tan, Thesis Honors Advisor

198. The Mechanism of NELF Recruitment by DSIF in Promoter-proximal Pausing of RNA Polymerase II

restricted_to_institution
Restricted (Penn State Only)
Author:
Deng, Eilene
Title:
The Mechanism of NELF Recruitment by DSIF in Promoter-proximal Pausing of RNA Polymerase II
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
promoter-proximal pausing
transcription factors
gene regulation
DSIF
NELF
RNA Polymerase II
File:
Login to Download
Thesis Supervisors:
David Scott Gilmour, Thesis Supervisor
Lorraine C Santy, Thesis Honors Advisor

200. The Effect of the Small RNA RyhB on the Structure of its mRNA Targets

restricted_to_institution
Restricted (Penn State Only)
Author:
Grecco, Samantha
Title:
The Effect of the Small RNA RyhB on the Structure of its mRNA Targets
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
sRNA
RyhB
gene expression profiling
in vivo chemical structure probing
pulldown assay
antibiotic resistance
structure-function relationship
File:
Login to Download
Thesis Supervisors:
Philip C Bevilacqua, Thesis Supervisor
Ying Gu, Thesis Honors Advisor