1. Small Molecule Inhibitors of the trans-translation Pathway Have Antibiotic Activity Against Mycobacterium smegmatis Open Access Author: Chambers, Benjamin Stewart Title: Small Molecule Inhibitors of the trans-translation Pathway Have Antibiotic Activity Against Mycobacterium smegmatis Area of Honors: Microbiology Keywords: smegmatistuberculosistbsmall molecule inhibitorstrans-translationtmRNAantibioticdrugchambers File: Download Chambers_Ben_smallmoleculeinhibitors.pdf Thesis Supervisors: Kenneth Charles Keiler, Thesis SupervisorDr. Sarah Ellen Ades, Thesis Honors AdvisorDr. Wendy Hanna-Rose, Faculty Reader
2. target identification and analysis of trans-translation inhibitor KKL-35 Open Access Author: Hosangadi, Divya Title: target identification and analysis of trans-translation inhibitor KKL-35 Area of Honors: Microbiology Keywords: antibiotictrans-translationbiochemistryE. coli File: Download Final_Undergraduate_Thesis_DHOSANGADI.pdf Thesis Supervisors: Kenneth Charles Keiler, Thesis SupervisorDr. Sarah Ellen Ades, Thesis Honors AdvisorScott Brian Selleck, Faculty Reader
3. Synthesis, Efficacy, and Molecular Targeting of Hydrazide Class trans-translation Inhibitors Open Access Author: Babunovic, Gregory Hunter Title: Synthesis, Efficacy, and Molecular Targeting of Hydrazide Class trans-translation Inhibitors Area of Honors: Microbiology Keywords: antibioticsbacteriatrans-translationinhibitorproteinclick chemistrysynthesishydrazidetargetpathogen File: Download G._H._Babunovic_Honors_Thesis_Final_15.pdf Thesis Supervisors: Kenneth Charles Keiler, Thesis SupervisorDr. Sarah Ellen Ades, Thesis Honors AdvisorScott Brian Selleck, Faculty Reader
4. Establishing the Role of FTL_1042 in the Intracellular Growth and Survival of Francisella tularensis Open Access Author: Avanzato, Victoria Alina Title: Establishing the Role of FTL_1042 in the Intracellular Growth and Survival of Francisella tularensis Area of Honors: Immunology and Infectious Disease Keywords: Francisella tularensisnovel antibioticstrans-translationvirulence factorsvaccines File: Download Avanzato_Thesis_2015.pdf Thesis Supervisors: Girish Soorappa Kirimanjeswara, Thesis SupervisorDr. Pamela A. Hankey-Giblin, Thesis Honors Advisor
5. Identifying inhibitors of trans‐translation in methicillin resistant Staphylococcus aureus Open Access Author: Rae, Christopher Donald Title: Identifying inhibitors of trans‐translation in methicillin resistant Staphylococcus aureus Area of Honors: Biochemistry and Molecular Biology Keywords: methicillin resistant Staphylococcus aureusMRSAantibiotictrans-translation File: Download Chris_Rae_Undergraduate_Honors_Thesis.pdf Thesis Supervisors: Kenneth Charles Keiler, Thesis SupervisorCraig Eugene Cameron, Thesis Honors AdvisorScott Brian Selleck, Faculty Reader
6. Characterization and Target Identification of Hydrazine carbonothiols, a class of trans-Translation Inhibitors Open Access Author: Miller, Sydney Alexis Title: Characterization and Target Identification of Hydrazine carbonothiols, a class of trans-Translation Inhibitors Area of Honors: Biochemistry and Molecular Biology Keywords: trans-translationhydrazine carbonothiolsantibiotic resistance File: Download Thesis.pdf Thesis Supervisors: Kenneth Charles Keiler, Thesis SupervisorDavid Scott Gilmour, Thesis Honors Advisor
7. Decoding the Mechanism of Action for Triazole and 8-hydroxyquinoline trans-Translation Inhibitors Open Access Author: Ryan, Taryn Jeanne Title: Decoding the Mechanism of Action for Triazole and 8-hydroxyquinoline trans-Translation Inhibitors Area of Honors: Biochemistry and Molecular Biology Keywords: trans-translationantibiotic resistance8-hydroxyquinolinetriazoleluciferase-basedclick chemistry File: Download Taryn_Ryan_Honors_Thesis.pdf Thesis Supervisors: Kenneth Charles Keiler, Thesis SupervisorDr. Teh-hui Kao, Thesis Honors AdvisorDr. Sarah Ellen Ades, Faculty Reader
8. INVESTIGATION OF THE MOLECULAR TARGETING MECHANISMS OF TRANS-TRANSLATION INHIBITORS AND DETERMINING THE ESSENTIAL NATURE OF TRANS-TRANSLATION IN STAPHYLOCOCCUS AUREUS Open Access Author: Victor, Samjeris Title: INVESTIGATION OF THE MOLECULAR TARGETING MECHANISMS OF TRANS-TRANSLATION INHIBITORS AND DETERMINING THE ESSENTIAL NATURE OF TRANS-TRANSLATION IN STAPHYLOCOCCUS AUREUS Area of Honors: Biochemistry and Molecular Biology Keywords: antibioticstrans-translationBiochemistry and Molecular BiologyS. aureus File: Download SV_Honors_Thesis_2018.pdf Thesis Supervisors: Kenneth Charles Keiler, Thesis SupervisorDr. Wendy Hanna-Rose, Thesis Honors Advisor
9. Identification and Characterization of trans-Translation Inhibitors Open Access Author: Davison, Alexis Title: Identification and Characterization of trans-Translation Inhibitors Area of Honors: Biochemistry and Molecular Biology Keywords: trans-translationantibiotic resistanceribosome profilingKKL-4669high-throughput screenluciferase reporter assaybacterial pathogensCaulobacterin vitro transcription/translation assay File: Download Davison_Alexis_Thesis_Sp2020.pdf Thesis Supervisors: Ken Keiler, Thesis SupervisorYing Gu, Thesis Honors Advisor
10. Looking At Natural Products As Inhibitors Of Ribosome Rescue and Delving Into ArfB Open Access Author: Osterhaus, Emma Title: Looking At Natural Products As Inhibitors Of Ribosome Rescue and Delving Into ArfB Area of Honors: Biochemistry and Molecular Biology Keywords: ribosome rescueantibiotic discoverynatural productstrans-translation File: Download Osterhaus_Final_Thesis_2021.pdf Thesis Supervisors: Kenneth Keiler, Thesis SupervisorJoseph C. Reese, Thesis Honors Advisor
11. New Antibiotics Found in Trans-Translation Pathway Restricted Author: Heilenman, Abigail Title: New Antibiotics Found in Trans-Translation Pathway Area of Honors: Biochemistry and Molecular Biology Keywords: trans-translationantibioticsantibiotic resistanceL27antibiotic targetsL27 ribosomal proteintrans-translation inhibitorsacylaminooxadiazoletetrazoletriazole File: No files available due to restrictions. Thesis Supervisors: Ken Keiler, Thesis SupervisorYing Gu, Thesis Honors Advisor
