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Start Over Area of Honors Biochemistry and Molecular Biology Degree B S

201. The Chemotherapeutic Agent CX-5461 Affects Cell Viability Through a Topoisomerase II Poison-Like Mechanism

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Restricted (Penn State Only)
Author:
Dennis, Kady
Title:
The Chemotherapeutic Agent CX-5461 Affects Cell Viability Through a Topoisomerase II Poison-Like Mechanism
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
CX-5461
mechanism of action
RNA Polymerase I inhibitor
Topoisomerase II poison
File:
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Thesis Supervisors:
Justin R Pritchard, Thesis Supervisor
Joseph C. Reese, Thesis Honors Advisor

202. Understanding the Mechanisms Controlling the Localization of Microtubule Organization Proteins in Drosophila Neurons

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Restricted (Penn State Only)
Author:
Long, Melissa
Title:
Understanding the Mechanisms Controlling the Localization of Microtubule Organization Proteins in Drosophila Neurons
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Drosophila
Neuroscience
Microtubule Nucleation
Clathrin-Mediated Endocytosis
Wnt Signaling
Dendrite
File:
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Thesis Supervisors:
Melissa Rolls, Thesis Supervisor
David Scott Gilmour, Thesis Honors Advisor

203. Development of a Functional RNA-Identifying Computational Pipeline and its Application to SARS-CoV-2

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Restricted (Penn State Only)
Author:
Forstmeier, Peter
Title:
Development of a Functional RNA-Identifying Computational Pipeline and its Application to SARS-CoV-2
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
SARS-CoV-2
RNA
pseudoknots
SNPs
RNA structure conservation
frameshifting element
FSE
File:
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Thesis Supervisors:
Philip C Bevilacqua, Thesis Supervisor
Teh-Hui Kao, Thesis Honors Advisor

205. High Resolution Structure and Neutralization Mechanism of 1G1 Fab Bound to Poliovirus Type 3

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Restricted (Penn State Only)
Author:
Faust, Julia
Title:
High Resolution Structure and Neutralization Mechanism of 1G1 Fab Bound to Poliovirus Type 3
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
CryoEM
poliovirus
SPV3
virology
neutralizing antibody
1G1 Fab
structural biology
File:
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Thesis Supervisors:
Susan Hafenstein, Thesis Supervisor
Timothy Charles Meredith, Thesis Honors Advisor

206. Cost-effective Molecular Weight Standards for Protein Size-exclusion Chromatography: HISftnA and HISDps Expression and Purification

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Restricted (Penn State Only)
Author:
Howells, Joshua
Title:
Cost-effective Molecular Weight Standards for Protein Size-exclusion Chromatography: HISftnA and HISDps Expression and Purification
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Size-exclusion chromatography
molecular weight standards
Escherichia coli bacterial ferritin
Escherichia coli DNA-binding protein from starved cells
File:
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Thesis Supervisors:
Song Tan, Thesis Supervisor
Song Tan, Thesis Honors Advisor
Jean-Paul Armache, Faculty Reader

215. Localization of PIP2 in HGF-stimulated epithelial cell migration and Integrin Recycling

open_access
Open Access
Author:
Buskirk, Austin
Title:
Localization of PIP2 in HGF-stimulated epithelial cell migration and Integrin Recycling
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
epithelial cell migration
integrin recycling
Phosphatidylinositol-4
5-biphosphate (PIP2)
Epithelial-Mesenchymal Transition
Endosomal System
File:
Download Corrected_Austin_Buskirk_thesis.pdf
Thesis Supervisors:
Lorraine C Santy, Thesis Supervisor
Teh-Hui Kao, Thesis Honors Advisor

216. 1. Characterization of Twisters Ribozymes at Splice Sites 2. Development of a Computational Pipeline to Discover Small Self-cleaving Ribozymes with Helical Imperfections

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Restricted (Penn State Only)
Author:
Chang, Benjamin
Title:
1. Characterization of Twisters Ribozymes at Splice Sites 2. Development of a Computational Pipeline to Discover Small Self-cleaving Ribozymes with Helical Imperfections
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
RNA
Ribozymes
Splicing
High-throughput Pipeline
File:
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Thesis Supervisors:
Philip C Bevilacqua, Thesis Supervisor
Joseph C. Reese, Thesis Honors Advisor

219. Adenylosuccinate Lyase Plays a Role in Neuromuscular Coordination

open_access
Open Access
Author:
Peifer, Mia
Title:
Adenylosuccinate Lyase Plays a Role in Neuromuscular Coordination
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
C. elegans
Adenylosuccinate Lyase Deficiency
Purine Metabolism
Neuromuscular Coordination
File:
Download Peifer_Mia_Adenylosuccinate_Lyase_Plays_a_Role_in_Neuromuscular_Coordination.pdf
Thesis Supervisors:
Wendy Hanna-Rose, Thesis Supervisor
Timothy Charles Meredith, Thesis Honors Advisor

220. Cost-effective Molecular Weight Standards for Protein Size Exclusion Chromatography

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Restricted (Penn State Only)
Author:
Sokol, Joshua
Title:
Cost-effective Molecular Weight Standards for Protein Size Exclusion Chromatography
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Size exclusion chromatography
Gel filtration chromatography
Globular
Liquid chromatography
Protein
Recombinant DNA
SEC-MALS
Analytical Ultracentrifugation
Sedimentation equilibrium
Metal affinity chromatography
Ion-exchange chromatography
Molecular weight
File:
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Thesis Supervisors:
Song Tan, Thesis Supervisor
Ying Gu, Thesis Honors Advisor

221. Characterizing rescue of an Alzheimer's disease model in Drosophila by downregulation of heparan sulfate biosynthetic enzymes and treatment by bosutinib

open_access
Open Access
Author:
Swanson, Lindsey
Title:
Characterizing rescue of an Alzheimer's disease model in Drosophila by downregulation of heparan sulfate biosynthetic enzymes and treatment by bosutinib
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Alzheimer's disease
Heparan sulfate
Lipid metabolism
Autophagy
Mitochondria
Presenilin
File:
Download Swanson_Lindsey_HonorsThesis.pdf
Thesis Supervisors:
Scott Brian Selleck, Thesis Supervisor
Sarah Mary Assmann, Thesis Honors Advisor

223. Investigating Strain Level Diversity Among Natural Co-Isolated Vibrio Fischeri

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Restricted (Penn State Only)
Author:
Harter, Rachel
Title:
Investigating Strain Level Diversity Among Natural Co-Isolated Vibrio Fischeri
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
transformation
bacteria
strain diversity
genomic
genetic
vibrio fischeri
symbiosis
mutualism
euprymna scolopes
microbiology
molecular biology
biochemistry
quorum sensing
File:
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Thesis Supervisors:
Timothy Iwao Miyashiro, Thesis Supervisor
Wendy Hanna-Rose, Thesis Honors Advisor

224. Investigating the Effects of H1N1 Influenza Infection on Vitamin D Metabolism and Response Gene Expression

open_access
Open Access
Author:
Kozloski, Suzanne
Title:
Investigating the Effects of H1N1 Influenza Infection on Vitamin D Metabolism and Response Gene Expression
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Vitamin D
influenza
immunology
vitamin d metabolism
immune response
File:
Download SuzanneKozloski_HonorsThesis.pdf
Thesis Supervisors:
Margherita Teresa-Anna Cantorna, Thesis Supervisor
Santhosh Girirajan, Thesis Honors Advisor