201. Characterization of the Injury Response of Ciliated Neurons in Drosophila Restricted (Penn State Only) Author: Mauger, Abigail Title: Characterization of the Injury Response of Ciliated Neurons in Drosophila Area of Honors: Biochemistry and Molecular Biology Keywords: axon injuryciliated neuronschordotonalDLKaxon regenerationDrosophilaneuronaxon File: Login to Download Thesis Supervisors: Melissa Rolls, Thesis SupervisorSanthosh Girirajan, Thesis Honors Advisor
202. The Chemotherapeutic Agent CX-5461 Affects Cell Viability Through a Topoisomerase II Poison-Like Mechanism Restricted (Penn State Only) Author: Dennis, Kady Title: The Chemotherapeutic Agent CX-5461 Affects Cell Viability Through a Topoisomerase II Poison-Like Mechanism Area of Honors: Biochemistry and Molecular Biology Keywords: CX-5461mechanism of actionRNA Polymerase I inhibitorTopoisomerase II poison File: Login to Download Thesis Supervisors: Justin R Pritchard, Thesis SupervisorJoseph C. Reese, Thesis Honors Advisor
203. Understanding the Mechanisms Controlling the Localization of Microtubule Organization Proteins in Drosophila Neurons Restricted (Penn State Only) Author: Long, Melissa Title: Understanding the Mechanisms Controlling the Localization of Microtubule Organization Proteins in Drosophila Neurons Area of Honors: Biochemistry and Molecular Biology Keywords: DrosophilaNeuroscienceMicrotubule NucleationClathrin-Mediated EndocytosisWnt SignalingDendrite File: Login to Download Thesis Supervisors: Melissa Rolls, Thesis SupervisorDavid Scott Gilmour, Thesis Honors Advisor
204. Development of a Functional RNA-Identifying Computational Pipeline and its Application to SARS-CoV-2 Restricted (Penn State Only) Author: Forstmeier, Peter Title: Development of a Functional RNA-Identifying Computational Pipeline and its Application to SARS-CoV-2 Area of Honors: Biochemistry and Molecular Biology Keywords: SARS-CoV-2RNApseudoknotsSNPsRNA structure conservationframeshifting elementFSE File: Login to Download Thesis Supervisors: Philip C Bevilacqua, Thesis SupervisorTeh-Hui Kao, Thesis Honors Advisor
205. Mechanistic Study of Halogenation by Iron(II) and 2-Oxoglutarate-Dependent Oxygenases Restricted (Penn State Only) Author: Katch, Bryce Title: Mechanistic Study of Halogenation by Iron(II) and 2-Oxoglutarate-Dependent Oxygenases Area of Honors: Biochemistry and Molecular Biology Keywords: EnzymologyStructural BiologyC-H ActivationSadABesD File: Login to Download Thesis Supervisors: Amie Kathleen Boal, Thesis SupervisorTimothy Charles Meredith, Thesis Honors Advisor
206. Identifying an MNase Sensitive Particle associated with Rap1 Restricted (Penn State Only) Author: Pitts, Cass Title: Identifying an MNase Sensitive Particle associated with Rap1 Area of Honors: Biochemistry and Molecular Biology Keywords: ChromatinNucleosome displacing factorsRap1SAGABudding yeastGene regulation File: Login to Download Thesis Supervisors: Lu Bai, Thesis SupervisorJoseph C. Reese, Thesis Honors Advisor
207. High Resolution Structure and Neutralization Mechanism of 1G1 Fab Bound to Poliovirus Type 3 Restricted (Penn State Only) Author: Faust, Julia Title: High Resolution Structure and Neutralization Mechanism of 1G1 Fab Bound to Poliovirus Type 3 Area of Honors: Biochemistry and Molecular Biology Keywords: CryoEMpoliovirusSPV3virologyneutralizing antibody1G1 Fabstructural biology File: Login to Download Thesis Supervisors: Susan Hafenstein, Thesis SupervisorTimothy Charles Meredith, Thesis Honors Advisor
208. Cost-effective Molecular Weight Standards for Protein Size-exclusion Chromatography: HISftnA and HISDps Expression and Purification Restricted (Penn State Only) Author: Howells, Joshua Title: Cost-effective Molecular Weight Standards for Protein Size-exclusion Chromatography: HISftnA and HISDps Expression and Purification Area of Honors: Biochemistry and Molecular Biology Keywords: Size-exclusion chromatographymolecular weight standardsEscherichia coli bacterial ferritinEscherichia coli DNA-binding protein from starved cells File: Login to Download Thesis Supervisors: Song Tan, Thesis SupervisorSong Tan, Thesis Honors AdvisorJean-Paul Armache, Faculty Reader
209. Engineering Mitochondrial Transport Control Using Miro1 Restricted (Penn State Only) Author: Litvak, Michelle Title: Engineering Mitochondrial Transport Control Using Miro1 Area of Honors: Biochemistry and Molecular Biology Keywords: miro1proteinmitochondrial File: Login to Download Thesis Supervisors: Nikolay Dokholyan, Thesis SupervisorSanthosh Girirajan, Thesis Honors AdvisorJean-Paul Armache, Faculty Reader
210. Investigating Regeneration, Function, and Shape of Drosophila Sensory Dendrites Restricted (Penn State Only) Author: Bernard, Annabelle Title: Investigating Regeneration, Function, and Shape of Drosophila Sensory Dendrites Area of Honors: Biochemistry and Molecular Biology Keywords: Dendrite regenerationDrosophila melanogasterNociceptionFunctional recoveryPruning File: Login to Download Thesis Supervisors: Melissa Rolls, Thesis SupervisorTimothy Charles Meredith, Thesis Honors Advisor
211. Optimization of Size Exclusion Chromatography Protein Standards Restricted (Penn State Only) Author: Mongia, Advay Title: Optimization of Size Exclusion Chromatography Protein Standards Area of Honors: Biochemistry and Molecular Biology Keywords: Size Exclusion ChromatographyProtein Standardsprotein expressionprotein purificationgel filtration chromatographybacterioferritin File: Login to Download Thesis Supervisors: Song Tan, Thesis SupervisorJoseph C. Reese, Thesis Honors Advisor
212. New Antibiotics Found in Trans-Translation Pathway Restricted Author: Heilenman, Abigail Title: New Antibiotics Found in Trans-Translation Pathway Area of Honors: Biochemistry and Molecular Biology Keywords: trans-translationantibioticsantibiotic resistanceL27antibiotic targetsL27 ribosomal proteintrans-translation inhibitorsacylaminooxadiazoletetrazoletriazole File: No files available due to restrictions. Thesis Supervisors: Ken Keiler, Thesis SupervisorYing Gu, Thesis Honors Advisor
213. Mechanisms of FXR Activation by Synthetic Ligands Restricted (Penn State Only) Author: Meinert, Emily Title: Mechanisms of FXR Activation by Synthetic Ligands Area of Honors: Biochemistry and Molecular Biology Keywords: nuclear receptorssite-directed mutagenesisdual luciferasetransformationmammalian cell culturesynthetic ligandbile acid File: Login to Download Thesis Supervisors: C Denise Okafor, Thesis SupervisorTeh-Hui Kao, Thesis Honors Advisor
214. Chemogenetically Induced Activation of Cortical Somatostatin Interneurons Results in Enhanced Pyramidal Neuron Activity in Rodent Models Restricted (Penn State Only) Author: Hutsell, Alexander Title: Chemogenetically Induced Activation of Cortical Somatostatin Interneurons Results in Enhanced Pyramidal Neuron Activity in Rodent Models Area of Honors: Biochemistry and Molecular Biology Keywords: Chronic StressChemogenetic ManipulationPrelimbic Cortexmedial prefrontal cortexSomatostatin InterneuronsPyramidal CellsInhibition and Excitation in the brain File: Login to Download Thesis Supervisors: Bernhard Luscher, Thesis SupervisorTimothy Charles Meredith, Thesis Honors Advisor
215. Engineering of an Aptamer Tagged Dengue Virus for RNA Imaging Restricted (Penn State Only) Author: Lombard, Clair Title: Engineering of an Aptamer Tagged Dengue Virus for RNA Imaging Area of Honors: Biochemistry and Molecular Biology Keywords: Dengue VirusFlavivirus Life CycleRNA Imaging Techniques File: Login to Download Thesis Supervisors: Joyce Jose, Thesis SupervisorTimothy Charles Meredith, Thesis Honors Advisor
216. The Toll of SARM1/TIR1—A Novel NAD-Consuming Enzyme Open Access Author: Argento, Ian Title: The Toll of SARM1/TIR1—A Novel NAD-Consuming Enzyme Area of Honors: Biochemistry and Molecular Biology Keywords: C. elegansNAD+MetabolomicsBiochemistryLongevity File: Download Argento_Ian_The_Toll_of_SARM1_TIR-1_A_Novel_NAD-Consuming_Enzyme.pdf Thesis Supervisors: Melanie Mc Reynolds, Thesis SupervisorLorraine C Santy, Thesis Honors Advisor
217. Associations Between Child Environmental Enteric Dysfunction And Stress Restricted (Penn State Only) Author: Bialek, Lexie Title: Associations Between Child Environmental Enteric Dysfunction And Stress Area of Honors: Biochemistry and Molecular Biology Keywords: Environmental Enteric DysfunctionOxidative stressBiomarkerGut-Brain Axis File: Login to Download Thesis Supervisors: Timothy Charles Meredith, Thesis SupervisorTeh-Hui Kao, Thesis Honors AdvisorAudrie Lin, Thesis Supervisor
218. Localization of PIP2 in HGF-stimulated epithelial cell migration and Integrin Recycling Open Access Author: Buskirk, Austin Title: Localization of PIP2 in HGF-stimulated epithelial cell migration and Integrin Recycling Area of Honors: Biochemistry and Molecular Biology Keywords: epithelial cell migrationintegrin recyclingPhosphatidylinositol-45-biphosphate (PIP2)Epithelial-Mesenchymal TransitionEndosomal System File: Download Corrected_Austin_Buskirk_thesis.pdf Thesis Supervisors: Lorraine C Santy, Thesis SupervisorTeh-Hui Kao, Thesis Honors Advisor
219. 1. Characterization of Twisters Ribozymes at Splice Sites 2. Development of a Computational Pipeline to Discover Small Self-cleaving Ribozymes with Helical Imperfections Restricted (Penn State Only) Author: Chang, Benjamin Title: 1. Characterization of Twisters Ribozymes at Splice Sites 2. Development of a Computational Pipeline to Discover Small Self-cleaving Ribozymes with Helical Imperfections Area of Honors: Biochemistry and Molecular Biology Keywords: RNARibozymesSplicingHigh-throughput Pipeline File: Login to Download Thesis Supervisors: Philip C Bevilacqua, Thesis SupervisorJoseph C. Reese, Thesis Honors Advisor
220. Resilience of the Symbiosis Between Vibrio fischeri and Euprymna scolopes Restricted (Penn State Only) Author: Cook, Rachel Title: Resilience of the Symbiosis Between Vibrio fischeri and Euprymna scolopes Area of Honors: Biochemistry and Molecular Biology Keywords: SymbiosisTransgenerational effectDietReproductionEuprymna scolopesVibrio fischeri File: Login to Download Thesis Supervisors: Wendy Hanna-Rose, Thesis Honors AdvisorTimothy Iwao Miyashiro, Thesis Supervisor