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201. Clinically Irrelevant Concentrations of Kinase Inhibitors Contribute to Failure of Drug Repurposing Efforts in Clinical Trials: a Meta-Analysis

open_access
Open Access
Author:
Shah, Anushka
Title:
Clinically Irrelevant Concentrations of Kinase Inhibitors Contribute to Failure of Drug Repurposing Efforts in Clinical Trials: a Meta-Analysis
Area of Honors:
Biology
Keywords:
clinical trials
repurposing
cancer
kinase inhibitors
meta-analysis
biology
in vitro
drug concentrations
File:
Download Shah_SHCThesis.pdf
Thesis Supervisors:
Justin R Pritchard, Thesis Supervisor
Richard W Ordway, Thesis Honors Advisor

202. Investigation of Striatal Astrocytes to GABAergic Neuron Conversion In Vivo in Huntington’s Disease Mouse Model

open_access
Open Access
Author:
Xu, Kevin
Title:
Investigation of Striatal Astrocytes to GABAergic Neuron Conversion In Vivo in Huntington’s Disease Mouse Model
Area of Honors:
Biology
Keywords:
ND1
Dlx2
Huntington's Disease
HD
GABAergic neurons
transcription factors
gene therapy
striatal astrocytes
R6/2 mouse model
astrocyte-to-neuron conversion
ND1
Dlx2
Huntington's Disease
HD
GABAergic neurons
transcription factors
gene therapy
striatal astrocytes
R6/2 mouse model
astrocyte-to-neuron conversion
File:
Download Xu_Kevin_Investigation_of_Striatal_Astrocytes_to_GABAergic_Neuron_Conversion_In_Vivo_in_Huntington_s_Disease_Mouse_Model.pdf
Thesis Supervisors:
Aimin Liu, Thesis Supervisor
Bernhard Luscher, Thesis Honors Advisor

203. Analyzing the evolution of the vaccine development process after the H1N1 Swine Flu Pandemic of 2009 to understand the process used to develop the COVID-19 vaccine

open_access
Open Access
Author:
Dahal, Sabina
Title:
Analyzing the evolution of the vaccine development process after the H1N1 Swine Flu Pandemic of 2009 to understand the process used to develop the COVID-19 vaccine
Area of Honors:
Biology
Keywords:
COVID-19
H1N1 Swine Flu of 2009
Influenza
Vaccine
Vaccine Development Process
Pandemic
mRNA vaccine
Evolution of Vaccine
File:
Download SabinaDahal_FinalThesis.pdf
Thesis Supervisors:
Nik Tsotakos, Thesis Supervisor
Sairam V Rudrabhatla, Thesis Honors Advisor

207. PFK-158 Increases Migration by Promoting Lipolysis and Fatty Acid Oxidation

open_access
Open Access
Author:
Bekker, Jennifer
Title:
PFK-158 Increases Migration by Promoting Lipolysis and Fatty Acid Oxidation
Area of Honors:
Biology
Keywords:
Epithelial-mesenchymal transition
EMT
PFK-158
metastasis
cell migration
cell proliferation
cancer cell metabolism
lipid metabolism
AMPK
HGF
File:
Download Bekker_Jennifer_PFK-158_Increases_Migration_by_Promoting_Lipolysis_and_Fatty_Acid_Oxidation.pdf
Thesis Supervisors:
Emily Sophia Bell, Thesis Supervisor
Michael Axtell, Thesis Honors Advisor

208. Determining the optimal substrate for the invasive New Zealand mud snail (Potamopyrgus antipodarum)

open_access
Open Access
Author:
Ghannam, Sally
Title:
Determining the optimal substrate for the invasive New Zealand mud snail (Potamopyrgus antipodarum)
Area of Honors:
Biology
Keywords:
New Zealand mud snail
Potamopyrgus antipodarum
invasive species
ecology
biology
periphyton
woody debris
leaf litter
Spirulina algae
optimal substrate
File:
Download Ghannam_Sally_Determining_the_Optimal_Substrate_for_the_Invasive_New_Zealand_Mud_Snail__Potamopyrgus_antipodarum_.pdf
Thesis Supervisors:
Edward P Levri, Thesis Supervisor
Laura Rotunno, Thesis Honors Advisor
Allison Cornell, Faculty Reader

209. Combinational Therapy for Acute Lymphoblastic Leukemia with Tyrosine Kinase Inhibitors and Bispecific T Cell Engagers In Vitro

open_access
Open Access
Author:
Shaffer, Mikayla
Title:
Combinational Therapy for Acute Lymphoblastic Leukemia with Tyrosine Kinase Inhibitors and Bispecific T Cell Engagers In Vitro
Area of Honors:
Biology
Keywords:
Acute Lymphoblastic Leukemia
Bispecific T Cell Engagers
Tyrosine Kinase Inhibitors
File:
Download Shaffer_Mikayla_Thesis_FINAL.pdf
Thesis Supervisors:
Cheng Dong, Thesis Supervisor
Timothy J Jegla, Thesis Honors Advisor
Justin R Pritchard, Thesis Supervisor

212. Using Artificial Intelligence to Recognize Wheat Stripe Rust Disease

open_access
Open Access
Author:
Singh, Vinay
Title:
Using Artificial Intelligence to Recognize Wheat Stripe Rust Disease
Area of Honors:
Biology
Keywords:
Artificial intelligence
Wheat stripe rust disease
Machine learning
Food insecurity
Climate change
Plant diseases
PlantVillage
File:
Download Singh_Vinay_Using_Artificial_Intelligence_to_Recognize_Wheat_Stripe_Rust_Disease.pdf
Thesis Supervisors:
David Hughes, Thesis Supervisor
Timothy J Jegla, Thesis Honors Advisor

213. Chromosome level genome assemblies of Drosophila pseudoobscura determine Cuernavaca sequence inversion breakpoints and rearrangement mechanisms

open_access
Open Access
Author:
Dutzman, Nicole
Title:
Chromosome level genome assemblies of Drosophila pseudoobscura determine Cuernavaca sequence inversion breakpoints and rearrangement mechanisms
Area of Honors:
Biology
Keywords:
Genetics
Drosophila pseudoobscura
Genome Assembly
Oxford Nanopore Sequencing
Chromosomal Inversions
Inversion Breakpoints
Cuernavaca
Heterozygosity
Repetitive Sequences
File:
Download Final_Thesis_Template.pdf
Thesis Supervisors:
Stephen Wade Schaeffer, Thesis Supervisor
Benoit A Dayrat, Thesis Honors Advisor

215. The Role of HDAC3 in Memory Updating via the Objects in Updated Locations (OUL) Task

open_access
Open Access
Author:
Wright, Destiny
Title:
The Role of HDAC3 in Memory Updating via the Objects in Updated Locations (OUL) Task
Area of Honors:
Biology
Keywords:
memory updating
aging
mice
memory reconsolidation
HDAC3
hippocampus
age-related cognitive decline
memory impairments
epigenetic mechanisms
File:
Download Destiny_Wright_Schreyer_Thesis_.pdf
Thesis Supervisors:
Janine Kwapis, Thesis Supervisor
Stephen Wade Schaeffer, Thesis Honors Advisor

216. A Measure of Platelet Activation and Aggregation Across Two Flow Regimes to Minimize Thromboembolic Events in Blood Pumps

open_access
Open Access
Author:
Sturgis, Hannah
Title:
A Measure of Platelet Activation and Aggregation Across Two Flow Regimes to Minimize Thromboembolic Events in Blood Pumps
Area of Honors:
Biology
Keywords:
thrombosis
flow cytometry
platelet activation
gel-filtered platelets
aggregation
File:
Download Sturgis_Hannah_thesis_FINAL.pdf
Thesis Supervisors:
Keefe B Manning, Thesis Supervisor
Benoit A Dayrat, Thesis Honors Advisor

217. A Longitudinal Analysis of Antibiotic Resistance in the Sediment Samples of the Delaware River Watershed and in the Clinical Infections in the Reading Hospital

open_access
Open Access
Author:
Sindhar, Safitaj
Title:
A Longitudinal Analysis of Antibiotic Resistance in the Sediment Samples of the Delaware River Watershed and in the Clinical Infections in the Reading Hospital
Area of Honors:
Biology
Keywords:
Antibiotic Resistance
Delaware River Watershed
Tetracycline
Ampicillin
Enterococcus
Escherichia coli
Polymerase Chain Reaction
DNA
Berks County
tet(A)
tet(R)
ctx
oxa
blaP
File:
Download Sindhar_Safitaj_LongitudinalAnalysisofAntibioticResistance.pdf
Thesis Supervisors:
Tami H Mysliwiec, Thesis Supervisor
Sandy Feinstein, Thesis Honors Advisor

218. Food Resilience in the Face of Catastrophic Global Events: Initial Computational Analysis of Nuclear Winter Scenarios on Rice

open_access
Open Access
Author:
Viswanathan, Vishnu
Title:
Food Resilience in the Face of Catastrophic Global Events: Initial Computational Analysis of Nuclear Winter Scenarios on Rice
Area of Honors:
Biology
Keywords:
nuclear
offset
genomics
rice
File:
Download Nuclear_Winter_Thesis_Revision_V2.pdf
Thesis Supervisors:
Jesse R Lasky, Thesis Supervisor
Stephen Wade Schaeffer, Thesis Honors Advisor

220. Cannabinoids as Neuroprotective Molecules in Photoreceptors following Light-Induced Retinal Degeneration in Zebrafish Retina

open_access
Open Access
Author:
Proano, Renata
Title:
Cannabinoids as Neuroprotective Molecules in Photoreceptors following Light-Induced Retinal Degeneration in Zebrafish Retina
Area of Honors:
Biology
Keywords:
cannabinoids
hemp
CBD
THC
Zebrafish
retina
age related macular degenaration
biology
therapeutic
neuroprotective
anti-inflammatory
rods
cones
photoreceptor
retinal degeneration
light-induced retinal degeneration
CB-13
novel therapy
immunofluorescence
animals
tissue preparation
cryosectioning
oxidative stress
endocannabinoid
receptors
model organism
File:
Download Renata_Proano_Thesis_Final_.pdf
Thesis Supervisors:
Salvatore Lucia Stella, Jr., Thesis Supervisor
Sairam V Rudrabhatla, Thesis Honors Advisor
Nik Tsotakos, Faculty Reader

221. Effect of DMN on Genes Associated with Ethylene Signaling and Metabolism in Solanum tuberosum

open_access
Open Access
Author:
Hannah, Summer
Title:
Effect of DMN on Genes Associated with Ethylene Signaling and Metabolism in Solanum tuberosum
Area of Honors:
Biology
Keywords:
Solanum tuberosum
DMN
RNA-seq
Gene expression
Ethylene Response Factor
ethylene signaling
ethylene metabolism
File:
Download Completed_Thesis.pdf
Thesis Supervisors:
Michael A Campbell, Thesis Supervisor
Diane Parente, Thesis Honors Advisor
Elisa Wu, Faculty Reader

222. Probing the Regulation of CSI1 Through its Phosphorylation

open_access
Open Access
Author:
Fliegel, Cara
Title:
Probing the Regulation of CSI1 Through its Phosphorylation
Area of Honors:
Biology
Keywords:
Cellulose
Cellulose Synthase Complex
Cellulose Synthase Interactive Protein 1
Phosphorylation
Hypocotyl Length
CSC Velocity
Cellulose Content
Arabidopsis thaliana
File:
Download Probing_the_Regulation_of_CSI1_Through_its_Phosphorylation_Fliegel.pdf
Thesis Supervisors:
Ying Gu, Thesis Supervisor
Benoit A Dayrat, Thesis Honors Advisor

224. The regulation of carnitine palmitoyltransferase 1 (CPT1) mRNA splicing by nutrient availability in Drosophila fat tissue

open_access
Open Access
Author:
Truong, Huy
Title:
The regulation of carnitine palmitoyltransferase 1 (CPT1) mRNA splicing by nutrient availability in Drosophila fat tissue
Area of Honors:
Biology
Keywords:
CPT1
splicing
mRNA
9G8
obesity
lipid
PKA
SR protein
starvation
isoforms
exon
triglyceride
File:
Download Thesis_HuyTruong.pdf
Thesis Supervisors:
Justin Di Angelo, Thesis Supervisor
Sandy Feinstein, Thesis Honors Advisor

228. Investigating the Role of STAT1 Transcription Factor in the Regulation of Schistosome Immunopathology

open_access
Open Access
Author:
Yi, Sara
Title:
Investigating the Role of STAT1 Transcription Factor in the Regulation of Schistosome Immunopathology
Area of Honors:
Biology
Keywords:
schistosome
mansoni
schistosomiasis
inflammation
inflammatory
stat1
stat3
infectious
disease
parasite
parasitic
worms
infect
interferon
ifn-1
ifn
cytokines
th2
th1
transcription factor
transcription
dendritic
cell
inflammasome
nlrp3
asc
il-10
il-1b
immunopathology
bmdc
cercariae
granule
fibrosis
trematode
immunology
immune
File:
Download Investigating_the_Role_of_STAT1_Transcription_Factor_in_the_Regulation_of_Schistosome_Immunopathology.pdf
Thesis Supervisors:
Parisa Kalantari, Thesis Supervisor
Stephen Wade Schaeffer, Thesis Honors Advisor

233. Post-Catastrophic Food Resilience: the Potential for Growing Fungi on Lignocellulosic Biomass as an Enzymatic Hydrolysis Pretreatment and as a Source of Human Nutrition

open_access
Open Access
Author:
Klatte, Hannah
Title:
Post-Catastrophic Food Resilience: the Potential for Growing Fungi on Lignocellulosic Biomass as an Enzymatic Hydrolysis Pretreatment and as a Source of Human Nutrition
Area of Honors:
Biology
Keywords:
Food Resilience
Biology
Analytical Biochemistry
Plant Biology
Mycology
Biofuels
File:
Download Hannah_Klatte_Honors_Thesis_in_Biology.pdf
Thesis Supervisors:
Charles T Anderson, Thesis Supervisor
Daniel J Cosgrove, Thesis Honors Advisor

234. An Analysis of the Evolutionary Advantages of Native Species in the Arid and Semi-Arid Landscapes of Northern Kenya

open_access
Open Access
Author:
Baron, Elizabeth
Title:
An Analysis of the Evolutionary Advantages of Native Species in the Arid and Semi-Arid Landscapes of Northern Kenya
Area of Honors:
Biology
Keywords:
Vachellia tortilis
Vachellia abyssinica
Salvadora persica
Sansevieria erythraeae
Balanites rotundifolia
Prosopis juliflora
ASAL
Arid and semi-arid landscapes
Kenya
Climate change
Adaptations
File:
Download An_Analysis_of_the_Evolutionary_Advantages_of_Native_Species_in_the_Arid_and_Semi-Arid_Landscapes_of_Northern_Kenya_.pdf
Thesis Supervisors:
David Hughes, Thesis Supervisor
Sarah Mary Assmann, Thesis Honors Advisor

235. Effect of Over-The-Counter Drugs on DNA Analysis of Blood Ingested by Medicinal Leeches

open_access
Open Access
Author:
Patel, Dipesh
Title:
Effect of Over-The-Counter Drugs on DNA Analysis of Blood Ingested by Medicinal Leeches
Area of Honors:
Biology
Keywords:
Drugs
DNA Analysis
Leeches
Aspirin
Ibuprofen
Caffeine
HPLC
DNA Extraction
DNA Quantification
File:
Download Patel_Dipesh_Effect_of_Over-The-Counter_Drugs_on_DNA_Analysis_of_Blood_Ingested_by_Medicinal_Leeches.pdf
Thesis Supervisors:
Reena Roy, Thesis Supervisor
Charles T Anderson, Thesis Honors Advisor

238. Binge Alcohol Consumption and Somatostatin Neuropeptide Dysregulation in the Prefrontal Cortex

open_access
Open Access
Author:
Kacala, Andrew
Title:
Binge Alcohol Consumption and Somatostatin Neuropeptide Dysregulation in the Prefrontal Cortex
Area of Honors:
Biology
Keywords:
Neurobiology
Alcohol Use Disorder
Somatostatin (SST)
Binge Drinking
Prefrontal Cortex
Pharmacology
Pharmacotherapy
File:
Download ANDREW_KACALA_THESIS_FALL_2023.pdf
Thesis Supervisors:
Nikki Crowley, Thesis Supervisor
Sarah Mary Assmann, Thesis Honors Advisor

239. Cortisol’s Effect on Iron Transport Proteins and Extracellular Vesicles Derived from Placental Trophoblast Cells

open_access
Open Access
Author:
Anderlind, Sophie
Title:
Cortisol’s Effect on Iron Transport Proteins and Extracellular Vesicles Derived from Placental Trophoblast Cells
Area of Honors:
Biology
Keywords:
Trophoblast Cells
Cortisol
Iron Transport Proteins
Extracellular Vesicles
TFR-1
FPN-1
Iron Trafficking
Pregnancy
File:
Download Schreyer_Final_Thesis___Sophie_Anderlind.pdf
Thesis Supervisors:
Nikki Crowley, Thesis Supervisor
Stephen Wade Schaeffer, Thesis Honors Advisor

240. Evaluating The Chronic Variable Stress Paradigm as a Model Suitable to Test for Stress Resilience of Mice

restricted_to_institution
Restricted (Penn State Only)
Author:
Botvinov, Julia
Title:
Evaluating The Chronic Variable Stress Paradigm as a Model Suitable to Test for Stress Resilience of Mice
Area of Honors:
Biology
Keywords:
stress resilience
GABA
anxiety
somatostatin
anhedonia
File:
Login to Download
Thesis Supervisors:
Bernhard Luscher, Thesis Supervisor
Bernhard Luscher, Thesis Honors Advisor
Yingwei Mao, Faculty Reader

242. The Role of Exon Junction Complex Factor RBM8A in Synapse Formation: A Glial Lens

restricted_to_institution
Restricted (Penn State Only)
Author:
Asthana, Shravan
Title:
The Role of Exon Junction Complex Factor RBM8A in Synapse Formation: A Glial Lens
Area of Honors:
Biology
Keywords:
Autism Spectrum Disorder
Attention Deficit Hyperactivity Disorder
ASD
ADHD
Neurodevelopmental Disorders
Neurology
Neuroscience
RBM8A
Exon Junction Complex
EJC
File:
Login to Download
Thesis Supervisors:
Yingwei Mao, Thesis Supervisor
Stephen Wade Schaeffer, Thesis Honors Advisor

247. Selective Blocking of Voltage-Gated Sodium Channels in the Frog Optic Nerve

restricted_to_institution
Restricted (Penn State Only)
Author:
Hallahan, Dana
Title:
Selective Blocking of Voltage-Gated Sodium Channels in the Frog Optic Nerve
Area of Honors:
Biology
Keywords:
Voltage-Gated Sodium Channels
Frog
Visual System
Optic Nerve
Optic Tectum
Retina
Nav
Prilocaine
Gene
Gene Sequences
TTX
Tetrodotoxin
Selective Blocking
Toxins
File:
Login to Download
Thesis Supervisors:
Elizabeth Anne Dudkin, Thesis Supervisor
Hans Schmidt, Thesis Honors Advisor

250. Comparative Transcriptomic Analysis of the Effect of Selenium on Industrial Hemp (Cannabis sativa)

restricted
Restricted
Author:
Patel, Aayushi
Title:
Comparative Transcriptomic Analysis of the Effect of Selenium on Industrial Hemp (Cannabis sativa)
Area of Honors:
Biology
Keywords:
Industrial Hemp
Transcriptomics
Selenium
Agriculture
Environment
Human Health
File:

No files available due to restrictions.

Thesis Supervisors:
Shobha Devi Rudrabhatla, Thesis Supervisor
Sairam V Rudrabhatla, Thesis Honors Advisor