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Start Over Area of Honors Biochemistry and Molecular Biology

101. CHARACTERIZATION OF THE ROLE OF UIS12 IN PLASMODIUM YOELII MALE GAMETOCYTE ACTIVATION

open_access
Open Access
Author:
Vrana, Erin Nicole
Title:
CHARACTERIZATION OF THE ROLE OF UIS12 IN PLASMODIUM YOELII MALE GAMETOCYTE ACTIVATION
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
malaria
Plasmodium yoelii
UIS12
translational repression
Biochemistry and Molecular Biology
File:
Download Honors_Thesis_Vrana_EN_final.pdf
Thesis Supervisors:
Scott Eugene Lindner, Thesis Supervisor
Dr. Sarah Ellen Ades, Thesis Honors Advisor

103. THE EPIGENETIC REGULATION OF PEPTIDYLARGININE DEIMINASE 4 AND ASSOCIATED CELLULAR RESPONSE PATHWAYS GIVE INSIGHT INTO NOVEL CANCER THERAPEUTICS

open_access
Open Access
Author:
Radaoui, Alexander Brown
Title:
THE EPIGENETIC REGULATION OF PEPTIDYLARGININE DEIMINASE 4 AND ASSOCIATED CELLULAR RESPONSE PATHWAYS GIVE INSIGHT INTO NOVEL CANCER THERAPEUTICS
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Cancer
PAD4
Epigenetics
CRISPR-Cas9
Molecular Cloning
File:
Download ALEX_RADAOUI_PDF_b.pdf
Thesis Supervisors:
Yanming Wang, Thesis Supervisor
David Scott Gilmour, Thesis Honors Advisor
Scott Brian Selleck, Faculty Reader

107. THE ROLE OF HEPATOCYTE GROWTH FACTOR IN LONG-TERM RENAL RECOVERY AFTER ACUTE KIDNEY INJURY IN MICE

open_access
Open Access
Author:
Pease, Lauren E
Title:
THE ROLE OF HEPATOCYTE GROWTH FACTOR IN LONG-TERM RENAL RECOVERY AFTER ACUTE KIDNEY INJURY IN MICE
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
renal iri
acute kidney injury
ischemia and reperfusion injury
HGF
cytohesin-2/ARNO
mice
File:
Download Pease_Thesis.pdf
Thesis Supervisors:
Dr. Lorraine C Santy, Thesis Supervisor
Dr. Wendy Hanna-Rose, Thesis Honors Advisor

108. THE EFFECT OF CYTOHESIN-2/ARNO COILED-COIL DOMAIN MUTATIONS ON ITS INTERACTION WITH SCAFFOLD PROTEINS GRASP AND IPCEF

open_access
Open Access
Author:
Marikunte, Sanjana S
Title:
THE EFFECT OF CYTOHESIN-2/ARNO COILED-COIL DOMAIN MUTATIONS ON ITS INTERACTION WITH SCAFFOLD PROTEINS GRASP AND IPCEF
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Cell Migration
HGF Signaling
ARF6
Cytohesin-2/ARNO
GRASP
IPCEF
File:
Download Marikunte_Sanjana_Honors_Thesis.pdf
Thesis Supervisors:
Dr. Lorraine C Santy, Thesis Supervisor
David Scott Gilmour, Thesis Honors Advisor

109. DYSFUNCTION IN THE BIOSYNTHETIC NAD+ SALVAGE PATHWAY AND PURINE BIOSYNTHESIS PATHWAY ALTER NEUROLOGICAL FUNCTION IN CAENORHABDITIS ELEGANS

open_access
Open Access
Author:
Rohan, Laura Elizabeth
Title:
DYSFUNCTION IN THE BIOSYNTHETIC NAD+ SALVAGE PATHWAY AND PURINE BIOSYNTHESIS PATHWAY ALTER NEUROLOGICAL FUNCTION IN CAENORHABDITIS ELEGANS
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
C. elegans
Metabolism
Neurological
Purine
Nicotinamide
Model system
File:
Download Rohan_Final_Thesis__1_.pdf
Thesis Supervisors:
Dr. Wendy Hanna-Rose, Thesis Supervisor
Dr. Teh-hui Kao, Thesis Honors Advisor

111. Characterization and Target Identification of Hydrazine carbonothiols, a class of trans-Translation Inhibitors

open_access
Open Access
Author:
Miller, Sydney Alexis
Title:
Characterization and Target Identification of Hydrazine carbonothiols, a class of trans-Translation Inhibitors
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
trans-translation
hydrazine carbonothiols
antibiotic resistance
File:
Download Thesis.pdf
Thesis Supervisors:
Kenneth Charles Keiler, Thesis Supervisor
David Scott Gilmour, Thesis Honors Advisor

113. GENOME-WIDE SCREEN FOR THE INDUCTION OF PHOSPHOETHANOLAMINE AND AMINOARABINOSE MODIFICATIONS ON ESCHERICHIA COLI LIPOPOLYSACCHARIDE

open_access
Open Access
Author:
Smith, Alexander Brock
Title:
GENOME-WIDE SCREEN FOR THE INDUCTION OF PHOSPHOETHANOLAMINE AND AMINOARABINOSE MODIFICATIONS ON ESCHERICHIA COLI LIPOPOLYSACCHARIDE
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Escherichia coli
lipopolysaccharide
phosphoethanolamine
microbiome
transposon sequencing
metabolic endotoxemia
eptA
feoB
File:
Download Smith_Alexander_LPSMod.pdf
Thesis Supervisors:
Timothy Meredith, Thesis Supervisor
Dr. Wendy Hanna-Rose, Thesis Honors Advisor

115. Caernorhabditis elegans model for 16p11.2 recurrent microdeletion suggests differential effects of conserved genes to knockdown

open_access
Open Access
Author:
Thomas, Ayush
Title:
Caernorhabditis elegans model for 16p11.2 recurrent microdeletion suggests differential effects of conserved genes to knockdown
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
C. elegans
16p11.2
Autism
Genetics
File:
Download AT_Thesis_SHC.pdf
Thesis Supervisors:
Dr. Santhosh Girirajan, Thesis Supervisor
David Scott Gilmour, Thesis Honors Advisor

116. The Importance of the Cpx Stress Response Pathway to Mecillinam Resistance in Escherichia Coli

open_access
Open Access
Author:
Sievers, Mary E
Title:
The Importance of the Cpx Stress Response Pathway to Mecillinam Resistance in Escherichia Coli
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Stress Responses
Cpx Stress Response Pathway
Mecillinam
Antibiotic Resistance
B-Lactam Antibiotics
Escherichia Coli
File:
Download Sievers_Thesis.pdf
Thesis Supervisors:
Dr. Sarah Ellen Ades, Thesis Supervisor
Craig Eugene Cameron, Thesis Honors Advisor

117. Direct Astrocyte-To-Neuron Conversion in Spinal Neurodegenerative Disease Models

open_access
Open Access
Author:
Keefe, Matthew George
Title:
Direct Astrocyte-To-Neuron Conversion in Spinal Neurodegenerative Disease Models
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
NeuroD1
neurodegenerative disease
spinal cord injury
ALS
neuroscience
transdifferentiation
File:
Download Matthew_Keefe_Honors_Thesis.pdf
Thesis Supervisors:
Dr. Gong Chen, Thesis Supervisor
Craig Eugene Cameron, Thesis Honors Advisor

119. Characterization of the Interaction Between S-Locus F-Box Proteins and S-Ribonucleases of Petunia inflata Through the Use of Chimeric S-Locus F-box Proteins and CRISPR/Cas9 Knockout

open_access
Open Access
Author:
Khatri, Wasi Asif
Title:
Characterization of the Interaction Between S-Locus F-Box Proteins and S-Ribonucleases of Petunia inflata Through the Use of Chimeric S-Locus F-box Proteins and CRISPR/Cas9 Knockout
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Petunia inflata
CRISPR/Cas9
Chimeric Proteins
SLF
S-RNase
petunia
self-incompatiblity
s-haplotype
File:
Download Khatri_Wasi_Thesis_3.31.18.pdf
Thesis Supervisors:
Dr. Teh-hui Kao, Thesis Supervisor
Dr. Teh-hui Kao, Thesis Honors Advisor
Ming Tien, Faculty Reader

120. AN EXAMINATION OF LOCOMOTIVE BEHAVIOR, GERMLINE PROLIFERATION, AND LIPID CONTENT IN A NOVEL AUTISM SPECTRUM DISORDER 16P11.2 DELETION CAENORHABDITIS ELEGANS MODEL

open_access
Open Access
Author:
Sullivan, Rhea Elena
Title:
AN EXAMINATION OF LOCOMOTIVE BEHAVIOR, GERMLINE PROLIFERATION, AND LIPID CONTENT IN A NOVEL AUTISM SPECTRUM DISORDER 16P11.2 DELETION CAENORHABDITIS ELEGANS MODEL
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
neurodevelopmental
disorders
autism
schizophrenia
16p11.2
deletion
Caenorhabditis elegans
intellectual disability
proliferation
obesity
worm
File:
Download Final_Draft_Sullivan.pdf
Thesis Supervisors:
Dr. Santhosh Girirajan, Thesis Supervisor
Dr. Lorraine C Santy, Thesis Honors Advisor

122. Decoding the Mechanism of Action for Triazole and 8-hydroxyquinoline trans-Translation Inhibitors

open_access
Open Access
Author:
Ryan, Taryn Jeanne
Title:
Decoding the Mechanism of Action for Triazole and 8-hydroxyquinoline trans-Translation Inhibitors
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
trans-translation
antibiotic resistance
8-hydroxyquinoline
triazole
luciferase-based
click chemistry
File:
Download Taryn_Ryan_Honors_Thesis.pdf
Thesis Supervisors:
Kenneth Charles Keiler, Thesis Supervisor
Dr. Teh-hui Kao, Thesis Honors Advisor
Dr. Sarah Ellen Ades, Faculty Reader

123. INVESTIGATION OF THE MOLECULAR TARGETING MECHANISMS OF TRANS-TRANSLATION INHIBITORS AND DETERMINING THE ESSENTIAL NATURE OF TRANS-TRANSLATION IN STAPHYLOCOCCUS AUREUS

open_access
Open Access
Author:
Victor, Samjeris
Title:
INVESTIGATION OF THE MOLECULAR TARGETING MECHANISMS OF TRANS-TRANSLATION INHIBITORS AND DETERMINING THE ESSENTIAL NATURE OF TRANS-TRANSLATION IN STAPHYLOCOCCUS AUREUS
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
antibiotics
trans-translation
Biochemistry and Molecular Biology
S. aureus
File:
Download SV_Honors_Thesis_2018.pdf
Thesis Supervisors:
Kenneth Charles Keiler, Thesis Supervisor
Dr. Wendy Hanna-Rose, Thesis Honors Advisor

124. Mechanisms Underlying the Effects of Edible Mushrooms on Gastrointestinal Health

open_access
Open Access
Author:
Roy, Pratiti
Title:
Mechanisms Underlying the Effects of Edible Mushrooms on Gastrointestinal Health
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Mushrooms
Intestinal gluconeogenesis
gut microbiota
gut-brain neural circuit
File:
Download Pratiti_Roy_Final_Draft.pdf
Thesis Supervisors:
Margherita Teresa-Anna Cantorna, Thesis Supervisor
Ming Tien, Thesis Honors Advisor
Andrew David Patterson, Faculty Reader

125. CONSTRUCTION AND CHARACTERIZATION OF A CYAN FLUORESCENT-EXPRESSING POLIOVIRUS

open_access
Open Access
Author:
Yang, Ziwei
Title:
CONSTRUCTION AND CHARACTERIZATION OF A CYAN FLUORESCENT-EXPRESSING POLIOVIRUS
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Virology
Biochemistry
Molecular Biology
Microbiology
Poliovirus
File:
Download Ziwei_Yang_s_Honors_Thesis_Final.pdf
Thesis Supervisors:
Craig Eugene Cameron, Thesis Supervisor
Craig Eugene Cameron, Thesis Honors Advisor
Joyce Jose, Faculty Reader

126. STUDY OF NUCLEOSOME DEPLETING FACTORS ON THE STOCHASTIC EXPRESSION OF THE YEAST HO PROMOTER

open_access
Open Access
Author:
O'Callaghan, Jessica
Title:
STUDY OF NUCLEOSOME DEPLETING FACTORS ON THE STOCHASTIC EXPRESSION OF THE YEAST HO PROMOTER
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Chromatin structure
NDRs
NDFs
Transcription regulation
Gene expression
Single-cell fluorescence microscopy
File:
Download Schreyer_Honors_Thesis.pdf
Thesis Supervisors:
Lu Bai, Thesis Supervisor
David Scott Gilmour, Thesis Honors Advisor

127. Determing Brain Regions Underlying an Antidepressant-like Phenotype in Mice

open_access
Open Access
Author:
Morris, Christian James
Title:
Determing Brain Regions Underlying an Antidepressant-like Phenotype in Mice
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
major depressive disorder
immunohistochemistry
somatostatin
Fos
stress
fluorescence microscopy
File:
Download Morris_Christian_Determining_Brain_Regions_Underlying_An_Antidepressantlike_Phenotype_In_Mice__.pdf
Thesis Supervisors:
Dr. Bernhard Lüscher, Thesis Supervisor
Ming Tien, Thesis Honors Advisor

129. Defining Stage-Specific and Constitutive Promoters in Plasmodium yoelii

open_access
Open Access
Author:
Finger, Logan
Title:
Defining Stage-Specific and Constitutive Promoters in Plasmodium yoelii
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Biochemistry and Molecular Biology
Malaria
Plasmodium
CRISPR/Cas9
Stage-Specific Promoters
Genetically Attenuated Parasites
File:
Download Finger_LE_Honors_Thesis_v3.pdf
Thesis Supervisors:
Scott Eugene Lindner, Thesis Supervisor
Joseph C. Reese, Thesis Honors Advisor

130. Diagnostic Evasion in Plasmodium falciparum Towards Hrp2-Sensitive Rapid Diagnostic Tests via pfhrp2 Gene Deletions

open_access
Open Access
Author:
Hollenbeak, Asher
Title:
Diagnostic Evasion in Plasmodium falciparum Towards Hrp2-Sensitive Rapid Diagnostic Tests via pfhrp2 Gene Deletions
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
malaria
rapid diagnostic tests
diagnostic
Plasmodium
falciparum
Linkage
Disequilibrium
File:
Download Hollenbeak_Thesis.pdf
Thesis Supervisors:
Maciej F Boni, Thesis Supervisor
Dr. Lorraine C Santy, Thesis Honors Advisor

131. CHARACTERIZATION OF GENETIC MUTATIONS IN EPIDEMIC STRAINS OF ZIKA VIRUS

open_access
Open Access
Author:
Horan, Sean
Title:
CHARACTERIZATION OF GENETIC MUTATIONS IN EPIDEMIC STRAINS OF ZIKA VIRUS
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Zika virus
mutation
NS5 polymerase
precursor membrane protein
envelope protein
pre-epidemic strain
epidemic strain
infection
virulence
convergent evolution
File:
Download Horan_FinalThesis.pdf
Thesis Supervisors:
Joyce Jose, Thesis Supervisor
Dr. Santhosh Girirajan, Thesis Honors Advisor

132. Structural Analysis of the Mixed Lineage Leukemia 3 (MLL3) Histone Methyltransferase Complex

open_access
Open Access
Author:
Sowers, Rosalie
Title:
Structural Analysis of the Mixed Lineage Leukemia 3 (MLL3) Histone Methyltransferase Complex
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
chromatin
nucleosome
x-ray crystallography
MLL
MWRA
histone methyltransferase
File:
Download Sowers_thesis_final.pdf
Thesis Supervisors:
Song Tan, Thesis Supervisor
Dr. Teh-hui Kao, Thesis Honors Advisor
Dr. Wendy Hanna-Rose, Faculty Reader

133. Examining Ribosomal Localization based on Microtubule Polarity in Drosophila melanogaster Neurons

open_access
Open Access
Author:
Lee, David Francis
Title:
Examining Ribosomal Localization based on Microtubule Polarity in Drosophila melanogaster Neurons
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Neurons
Drosophila
Ribosomes
Microtubules
Rolls
Lee
Fluorescent Microscopy
Developmental Biology
Biochemistry
Molecular Biology
Neuroscience
Trafficking
File:
Download FINAL.Thesis.Lee.David.pdf
Thesis Supervisors:
Melissa Rolls, Thesis Supervisor
David Scott Gilmour, Thesis Honors Advisor

134. The Effect of Subunit Deletions on SAGA Complex Binding in Sacharomyces Cerevisiae

open_access
Open Access
Author:
Driban, Matthew
Title:
The Effect of Subunit Deletions on SAGA Complex Binding in Sacharomyces Cerevisiae
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Yeast
Genomics
SAGA
Transcription
ChIP
Preinitiation Complex
TBP
Pol II
Knockouts
Heat Shock
Cell Stress
File:
Download MDriban_Thesis.pdf
Thesis Supervisors:
Benjamin Franklin Pugh, Thesis Supervisor
Craig Eugene Cameron, Thesis Honors Advisor

135. MANIPULATION OF NAD+ IN C. ELEGANS AFFECTS HATCHING, LIFESPAN, AND SENSORY OUTPUT

open_access
Open Access
Author:
La Ganke, Nicole
Title:
MANIPULATION OF NAD+ IN C. ELEGANS AFFECTS HATCHING, LIFESPAN, AND SENSORY OUTPUT
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Nicotinamide adenine dinucleotide
C. elegans
sirtuins
oxidative stress
lifespan
delayed hatching
sensory response
File:
Download LaGanke_Final_Thesis.pdf
Thesis Supervisors:
Dr. Wendy Hanna-Rose, Thesis Supervisor
Dr. Teh-hui Kao, Thesis Honors Advisor

139. Effects of Breaking Spectrin Network via Tobacco Etch Virus Protease on Heart and Fight Muscle in Drosophila

open_access
Open Access
Author:
Kiran, Amogh
Title:
Effects of Breaking Spectrin Network via Tobacco Etch Virus Protease on Heart and Fight Muscle in Drosophila
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
spectrin
cytoskeleton
drosophila heart
TEV protease
spectrin cleavage
File:
Download final_thesis_submission.pdf
Thesis Supervisors:
Claire Madison Thomas, Thesis Supervisor
Dr. Wendy Hanna-Rose, Thesis Honors Advisor

140. CHARACTERIZATION OF THE FaRLiP PHYCOBILIPROTEIN COMPLEX BY DELETION MUTAGENESIS IN THE CYANOBACTERIUM SYNECHOCOCCUS SP. PCC 7335

open_access
Open Access
Author:
Turner, Gavin M
Title:
CHARACTERIZATION OF THE FaRLiP PHYCOBILIPROTEIN COMPLEX BY DELETION MUTAGENESIS IN THE CYANOBACTERIUM SYNECHOCOCCUS SP. PCC 7335
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
FaRLiP
Cyanobacteria
Phycobilisome
Synechococcus sp. PCC 7335
File:
Download Turner_Gavin_FaRLiP_7335.pdf
Thesis Supervisors:
Donald Ashley Bryant, Thesis Supervisor
Dr. Ronald Albert Markle, Thesis Honors Advisor

142. CHARACTERIZATION OF A LIBRARY OF DEGENERATE OPERATOR SITES FOR THE TRANSCRIPTION FACTOR BETI FOR USE IN A MODEL-GUIDED DYNAMIC TIME-DELAY GENETIC CIRCUIT

open_access
Open Access
Author:
Clauer, Phillip
Title:
CHARACTERIZATION OF A LIBRARY OF DEGENERATE OPERATOR SITES FOR THE TRANSCRIPTION FACTOR BETI FOR USE IN A MODEL-GUIDED DYNAMIC TIME-DELAY GENETIC CIRCUIT
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Synthetic Biology
Metabolic Engineering
Biological Engineering
File:
Download Thesis_Clauer.pdf
Thesis Supervisors:
Dr. Howard M Salis, Thesis Supervisor
Dr. Wendy Hanna-Rose, Thesis Honors Advisor

143. POTENTIAL ROLE OF A TYROSINE LIGAND IN STABILIZING THE MIXED-VALENT DIIRON (II/III) COFACTOR OF MYO-INOSITOL OXYGENASE

open_access
Open Access
Author:
Cioffi, Katherine Joyann
Title:
POTENTIAL ROLE OF A TYROSINE LIGAND IN STABILIZING THE MIXED-VALENT DIIRON (II/III) COFACTOR OF MYO-INOSITOL OXYGENASE
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
myo-inositol oxygenase
metalloenzymes
mixed-valent diiron oxygenase
enzymology
File:
Download Cioffi_Final.pdf
Thesis Supervisors:
Joseph M Bollinger Jr., Thesis Supervisor
Craig Eugene Cameron, Thesis Honors Advisor

144. INVESTIGATING THE MECHANISM OF NEUROD1 IN ASTROCYTE REPROGRAMMING BY CHROMATIN IMMUNOPRECIPITATION

open_access
Open Access
Author:
Jayachandran, Kailash
Title:
INVESTIGATING THE MECHANISM OF NEUROD1 IN ASTROCYTE REPROGRAMMING BY CHROMATIN IMMUNOPRECIPITATION
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Neuroscience
NeuroD1
Astrocytes
Glutamatergic Neurons
Reprogramming
Maria Krasilnikova
Kailash Jayachandran
File:
Download Jayachandran_Kailash_NeuroD1.pdf
Thesis Supervisors:
Maria Krasilnikova, Thesis Supervisor
Dr. Santhosh Girirajan, Thesis Honors Advisor

145. Examining Drosophila melanogaster wing size upon tissue specific RNAi-induced knockdown of candidate gene regions of neurodevelopmental disorders

open_access
Open Access
Author:
Sarker, Avik Moni
Title:
Examining Drosophila melanogaster wing size upon tissue specific RNAi-induced knockdown of candidate gene regions of neurodevelopmental disorders
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Drosophila
neurodevelopmental disorder
CNV
RNAi
UAS/Gal4
deficiency
microdeletion
File:
Download ASarker_Thesis_SHC_Final_Submission.pdf
Thesis Supervisors:
Dr. Santhosh Girirajan, Thesis Supervisor
Dr. Santhosh Girirajan, Thesis Honors Advisor
David Scott Gilmour, Faculty Reader

146. Development of High Strength, Rapidly Degradable Bone Composites for Treatment of Osteoporosis

open_access
Open Access
Author:
Smith, Jessica
Title:
Development of High Strength, Rapidly Degradable Bone Composites for Treatment of Osteoporosis
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
biomaterials
citrate
osteoporosis
orthopedics
orthopedic materials
orthopedic fractures
POC
biomedical engineering
material science
bioengineering
xylitol
File:
Download BME_Thesis.pdf
Thesis Supervisors:
Jian Yang, Thesis Supervisor
Ying Gu, Thesis Honors Advisor

147. In Vitro Examination and Detection of a Triplex Structure Produced as a Result of a GAA Trinucleotide Repeat Sequence in Patients with Friedreich's Ataxia

open_access
Open Access
Author:
Pettoruto, Zachary
Title:
In Vitro Examination and Detection of a Triplex Structure Produced as a Result of a GAA Trinucleotide Repeat Sequence in Patients with Friedreich's Ataxia
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Friedreich's Ataxia
Triplex
Triplex Structure
Trinucleotide Repeat
GAA
In vitro
Microsatellite
Chemical Modification
File:
Download Zack_Pettoruto_-_Schreyer_Honors_College_Thesis_Final_Submission_2020.pdf
Thesis Supervisors:
Maria Krasilnikova, Thesis Supervisor
Ming Tien, Thesis Honors Advisor

149. Exploring The Interaction Between Colicin B And The TonB Dependent Transporter FepA Using Colicin B Mutants

open_access
Open Access
Author:
Bhimwal, Rijul
Title:
Exploring The Interaction Between Colicin B And The TonB Dependent Transporter FepA Using Colicin B Mutants
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
TonB
Colicin B
FepA
Outer Membrane
Bacteriocin
Escherichia coli
Gram-negative
File:
Download Rijul_Bhimwal_Honors_Thesis.pdf
Thesis Supervisors:
Kathleen Postle, Thesis Supervisor
David Scott Gilmour, Thesis Honors Advisor

154. Diffusion of Bacterial Quorum Sensing Molecules within the Squid Light Organ

open_access
Open Access
Author:
Yount, Taylor
Title:
Diffusion of Bacterial Quorum Sensing Molecules within the Squid Light Organ
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Quorum Sensing
Host-Microbe Symbiosis
Strain Diversity
Bacteria
Vibrio fischeri
Squid
Euprymna scolopes
Bioluminescence
File:
Download Taylor_Yount_Thesis.pdf
Thesis Supervisors:
Timothy Iwao Miyashiro, Thesis Supervisor
Santhosh Girirajan, Thesis Honors Advisor

156. Investigating the Role of FakA and FakB in Lipoprotein Biosynthesis in Staphylococcus aureus

open_access
Open Access
Author:
Hussain, Sheherbano
Title:
Investigating the Role of FakA and FakB in Lipoprotein Biosynthesis in Staphylococcus aureus
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
lipoproteins
FakA
FakB
staphylococcus aureus
TLR activity
acylation
TLR2/1
TLR2/6
fatty acids
File:
Download hussain_sheherbano.pdf
Thesis Supervisors:
Timothy Charles Meredith, Thesis Supervisor
Santhosh Girirajan, Thesis Honors Advisor

158. Identification and Characterization of trans-Translation Inhibitors

open_access
Open Access
Author:
Davison, Alexis
Title:
Identification and Characterization of trans-Translation Inhibitors
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
trans-translation
antibiotic resistance
ribosome profiling
KKL-4669
high-throughput screen
luciferase reporter assay
bacterial pathogens
Caulobacter
in vitro transcription/translation assay
File:
Download Davison_Alexis_Thesis_Sp2020.pdf
Thesis Supervisors:
Ken Keiler, Thesis Supervisor
Ying Gu, Thesis Honors Advisor

160. Designing Optimized Protein Molecular Weight Markers Applicable to both Coomassie Staining and Western Blotting

open_access
Open Access
Author:
Shibata, Yoshitaka Joey
Title:
Designing Optimized Protein Molecular Weight Markers Applicable to both Coomassie Staining and Western Blotting
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
protein molecular weight markers
SDS-PAGE
Western blotting
IgG antibody binding
polycistronic expression
protein expression
protein purification
File:
Download Shibata_Thesis_DesigningOptimizedProteinMWMarkers.pdf
Thesis Supervisors:
Song Tan, Thesis Supervisor
Wendy Hanna-Rose, Thesis Honors Advisor

161. Functional characterization of an ApiAP2 transcription factor in sexual development of Plasmodium falciparum

open_access
Open Access
Author:
Suhendra, Michelle
Title:
Functional characterization of an ApiAP2 transcription factor in sexual development of Plasmodium falciparum
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
malaria
gene regulation
transcription
transcription regulation
falciparum
plasmodium
apiap2
File:
Download Suhendra-thesis-final.pdf
Thesis Supervisors:
Manuel Llinas, Thesis Supervisor
Paul Babitzke, Thesis Honors Advisor

165. Comparative Analysis Between SARS-CoV, MERS-CoV, and SARS-CoV-2: Genomic Similarity, Spike Protein Homology, and Government Funding as it Relates to Vaccine Development

open_access
Open Access
Author:
Foresman, Bridget
Title:
Comparative Analysis Between SARS-CoV, MERS-CoV, and SARS-CoV-2: Genomic Similarity, Spike Protein Homology, and Government Funding as it Relates to Vaccine Development
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
SARS-CoV
SARS-CoV-2
Vaccine Development
MERS-CoV
Government Funding
NIH RePORTER
File:
Download BridgetForesman_FinalThesis.pdf
Thesis Supervisors:
Joel E Segel, Thesis Supervisor
Teh-Hui Kao, Thesis Honors Advisor

167. Investigation of The Biodegradation of Lipopolysaccharides by Bacillus spp Through ELISA and Polyacrylamide Gel Electrophoresis Silver Staining

open_access
Open Access
Author:
Dong, Shiwei
Title:
Investigation of The Biodegradation of Lipopolysaccharides by Bacillus spp Through ELISA and Polyacrylamide Gel Electrophoresis Silver Staining
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Lipopolysaccharides
Bacillus spp
Biodegradation of LPS
endotoxin
LPS
File:
Download Investigation_of_The_Biodegradation_of_Lipopolysaccharides_by_Bacillus_spp_Through_ELISA_and_Polyacrylamide_Gel_Electrophoresis_Silver_Staining.pdf
Thesis Supervisors:
Timothy Charles Meredith, Thesis Supervisor
Ming Tien, Thesis Honors Advisor

168. Studying the Role of Cyclin Dependent Kinase 5 (Cdk5) in Maintaining Healthy Neuronal Functions in Class I Dendritic Aborization Neurons of Drosophila

open_access
Open Access
Author:
Rudisill, Katelyn
Title:
Studying the Role of Cyclin Dependent Kinase 5 (Cdk5) in Maintaining Healthy Neuronal Functions in Class I Dendritic Aborization Neurons of Drosophila
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Drosophila
Microtubules
Biochemistry
Molecular Biology
Neurons
File:
Download Katelyn_Rudisill_Thesis.pdf
Thesis Supervisors:
Melissa Rolls, Thesis Supervisor
Song Tan, Thesis Honors Advisor

171. Investigating the molecular mechanisms of axon and dendrite regeneration in Drosophila peripheral neurons.

open_access
Open Access
Author:
Swope, Rachel
Title:
Investigating the molecular mechanisms of axon and dendrite regeneration in Drosophila peripheral neurons.
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
axon regeneration
dendrite regeneration
Drosophila melanogaster
Exocyst complex
endoplasmic reticulum
membrane
File:
Download thesis_FINAL_in_template.pdf
Thesis Supervisors:
Melissa Rolls, Thesis Supervisor
Ming Tien, Thesis Honors Advisor

176. Characterizing the Degradation of Cellulose by Combinations of Cellulolytic Enzymes

open_access
Open Access
Author:
Starr, Thomas
Title:
Characterizing the Degradation of Cellulose by Combinations of Cellulolytic Enzymes
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Biomass Conversion
Cellulases
Cellobiohyrdolases
Cellulose
Enzyme Synergy
Endoglucanases
File:
Download Thomas_Starr_Honors_Thesis_-_Final.pdf
Thesis Supervisors:
Charles T Anderson, Thesis Supervisor
Teh-Hui Kao, Thesis Honors Advisor

179. Characterizing the impacts of ornithine decarboxylase, spermidine synthase, and spermine synthase on polyamine pathway regulation and cell metabolism changes in Drosophila melanogaster

open_access
Open Access
Author:
Morales, Tahj
Title:
Characterizing the impacts of ornithine decarboxylase, spermidine synthase, and spermine synthase on polyamine pathway regulation and cell metabolism changes in Drosophila melanogaster
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Biochemistry
Polyamines
Drosophila Melanogaster
Metabolism
Ornithine decarboxylase
Spermidine synthase
Spermine synthase
Molecular Biology
File:
Download MoralesTahj_Thesis_Final.pdf
Thesis Supervisors:
Shannon Lyn Nowotarski, Thesis Supervisor
Sandy Feinstein, Thesis Honors Advisor

181. An Inside Look on Eutrophication in the Blue Marsh Reservoir by Identifying Cyanobacteria and Their Associated Toxin Genes: A Method to Use Cyanophages to Decrease Harmful Algal Blooms

open_access
Open Access
Author:
Moawad, Rana
Title:
An Inside Look on Eutrophication in the Blue Marsh Reservoir by Identifying Cyanobacteria and Their Associated Toxin Genes: A Method to Use Cyanophages to Decrease Harmful Algal Blooms
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
eutrophication
harmful algal blooms
cyanobacteria
Blue Marsh Reservoir
HABs
cyanophages
water quality
anthropogenic
File:
Download Moawad__Rana_Schreyer_Thesis_May_2022_FINAL_Complete_Submit_.pdf
Thesis Supervisors:
Tami H Mysliwiec, Thesis Supervisor
Sandy Feinstein, Thesis Honors Advisor

182. Exploring the Causes of Muscle Dysfunction Associated with Adenylosuccinate Lyase Deficiency in the Model Organism Caenorhabditis elegans

open_access
Open Access
Author:
Jan, Judy
Title:
Exploring the Causes of Muscle Dysfunction Associated with Adenylosuccinate Lyase Deficiency in the Model Organism Caenorhabditis elegans
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
C. elegans
Muscle Function
Adenylosuccinate Lyase Deficiency
Purine Metabolism
File:
Download Final_Thesis_Draft_Judy_Jan.pdf
Thesis Supervisors:
Wendy Hanna-Rose, Thesis Supervisor
David Scott Gilmour, Thesis Honors Advisor

185. Developing an in vitro Protease Assay for Determining the Transmembrane Topology of SARS-CoV-2 nsp6

open_access
Open Access
Author:
Nasal, Benjamin
Title:
Developing an in vitro Protease Assay for Determining the Transmembrane Topology of SARS-CoV-2 nsp6
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
SARS
COVID
coronavirus
protein topology
transmembrane
protease
microscopy
live cell imaging
western blotting
double membrane vesicle
File:
Download Schreyer_Thesis_FINAL_COPY.pdf
Thesis Supervisors:
Joyce Jose, Thesis Supervisor
Joseph C. Reese, Thesis Honors Advisor

187. The Properties and Location of Anisosome-Forming RNA-binding deficient TAR DNA-binding Protein 43 inside the Nucleus

open_access
Open Access
Author:
Mertick Sykes, Eli
Title:
The Properties and Location of Anisosome-Forming RNA-binding deficient TAR DNA-binding Protein 43 inside the Nucleus
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Protein
Liquid-Liquid Phase Separation
TDP-43
Mammalian Cells
Immunofluorescence
File:
Download Eli_Mertick-Sykes_Thesis_Final.pdf
Thesis Supervisors:
Xin Zhang, Thesis Supervisor
Song Tan, Thesis Honors Advisor

189. Use of Recombinant Urocanase to Study the Inhibitory Effects of Imidazolone Propionate Breakdown Products on Aspartate Aminotransferase

open_access
Open Access
Author:
Ruud, Isabella
Title:
Use of Recombinant Urocanase to Study the Inhibitory Effects of Imidazolone Propionate Breakdown Products on Aspartate Aminotransferase
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
aspartate aminotransferase
urocanase
histidine metabolism
enzyme inhibition
metabolic enzyme deficiencies
File:
Download IAR_Thesis_Final_PDF.pdf
Thesis Supervisors:
Allen T Phillips, Thesis Supervisor
Lorraine C Santy, Thesis Honors Advisor

190. Investigation into the HutD Protein within the Histidine Utilization (hut) Pathway in Pseudomonas putida

open_access
Open Access
Author:
Guzman, Nicholas
Title:
Investigation into the HutD Protein within the Histidine Utilization (hut) Pathway in Pseudomonas putida
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Histidine
Histidine Utilization Pathway (Hut)
HutC
HutD
repressor
promoter
operator
beta-galactosidase
pET vectors
Protein Overexpression
SDS-PAGE
Nickel-IMAC
Molecular Cloning
File:
Download Thesis_Final_Version_-_Guzman.pdf
Thesis Supervisors:
Joseph C. Reese, Thesis Supervisor
Allen T Phillips, Thesis Honors Advisor

192. Is there a Trade-off? Impacts of Antibiotic Treatments on Gut Microbiota and Immune Gene Expression in Honey Bees (Apis Mellifera)

open_access
Open Access
Author:
Tomasko, Nicholas
Title:
Is there a Trade-off? Impacts of Antibiotic Treatments on Gut Microbiota and Immune Gene Expression in Honey Bees (Apis Mellifera)
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Apis mellifera
Oxytetracycline
E. coli
Microbiome
Antimicrobial peptides
Immune genes
Immune response
File:
Download Tomasko_Nicholas_Final_Thesis.pdf
Thesis Supervisors:
Margarita Maria Lopez-Uribe, Thesis Supervisor
Joseph C. Reese, Thesis Honors Advisor

194. AHR Activation Affects Enteric Neuronal Survival by Inducing Apoptosis

open_access
Open Access
Author:
Kumar, Supriya
Title:
AHR Activation Affects Enteric Neuronal Survival by Inducing Apoptosis
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Aryl Hydrocarbon Receptor
TCDD
Enteric Nervous System
Persistant Organic Pollutant
Ceramide Synthesizing Genes
Apoptosis
Longitudinal Muscle Myenteric Plexus
Gut Motility
IM-FEN Cells
Neuronal Marker Genes
Nitrergic Neurons
Cholinergic Neurons
GI Tract
File:
Download Supriya_Kumar_Thesis_AHR_Activation_Affects_Enteric_Neuronal_Survival_by_Inducing_Apoptosis_.pdf
Thesis Supervisors:
Andrew Patterson, Thesis Supervisor
Joseph C. Reese, Thesis Honors Advisor

195. Assessing Sex Bias in Neurodevelopmental Disease-Associated Genes

open_access
Open Access
Author:
Scanlon, Bradley
Title:
Assessing Sex Bias in Neurodevelopmental Disease-Associated Genes
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
genetics
drosophila melanogaster
sex bias
neurodevelopmental diseases
genes
molecular biology
RNA interference
File:
Download Scanlon_Finalthesis.pdf
Thesis Supervisors:
Santhosh Girirajan, Thesis Supervisor
Santhosh Girirajan, Thesis Honors Advisor
Scott Brian Selleck, Faculty Reader

196. Topic Modeling as an Approach to Deduce Tissue-Specific Regions in the Human Genome

open_access
Open Access
Author:
Patel, Radha
Title:
Topic Modeling as an Approach to Deduce Tissue-Specific Regions in the Human Genome
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Topic Modeling
Transcription Factor Binding
Latent Dirichlet Allocation
Regulatory DNA Sequences
Tissue-Specific Regions
Human Genome
File:
Download final_draft_thesis.pdf
Thesis Supervisors:
Shaun Mahony, Thesis Supervisor
Santhosh Girirajan, Thesis Honors Advisor

197. Synthesis of Phosphatidylinositol 4,5-bisphosphate (PIP2) in Endosomal Compartments during Serum-Stimulated Cell Signaling

open_access
Open Access
Author:
Lee, Ellen
Title:
Synthesis of Phosphatidylinositol 4,5-bisphosphate (PIP2) in Endosomal Compartments during Serum-Stimulated Cell Signaling
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
integrin recycling
epithelial cell migration
cancer
endosomes
File:
Download Lee_Ellen_Thesis2.pdf
Thesis Supervisors:
Lorraine C Santy, Thesis Supervisor
Song Tan, Thesis Honors Advisor

198. The Mechanism of NELF Recruitment by DSIF in Promoter-proximal Pausing of RNA Polymerase II

restricted_to_institution
Restricted (Penn State Only)
Author:
Deng, Eilene
Title:
The Mechanism of NELF Recruitment by DSIF in Promoter-proximal Pausing of RNA Polymerase II
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
promoter-proximal pausing
transcription factors
gene regulation
DSIF
NELF
RNA Polymerase II
File:
Login to Download
Thesis Supervisors:
David Scott Gilmour, Thesis Supervisor
Lorraine C Santy, Thesis Honors Advisor

200. The Effect of the Small RNA RyhB on the Structure of its mRNA Targets

restricted_to_institution
Restricted (Penn State Only)
Author:
Grecco, Samantha
Title:
The Effect of the Small RNA RyhB on the Structure of its mRNA Targets
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
sRNA
RyhB
gene expression profiling
in vivo chemical structure probing
pulldown assay
antibiotic resistance
structure-function relationship
File:
Login to Download
Thesis Supervisors:
Philip C Bevilacqua, Thesis Supervisor
Ying Gu, Thesis Honors Advisor