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Start Over Area of Honors Biochemistry and Molecular Biology

51. The Role of Peroxisome Proliferator-Activated Receptor-b/d (PPARb/d) in Transforming Growth Factor b-Induced Epithelial-Mesenchymal Transition (EMT) of Human Lung Adenocarcinoma Cell Line

open_access
Open Access
Author:
Ali, Ayesha S
Title:
The Role of Peroxisome Proliferator-Activated Receptor-b/d (PPARb/d) in Transforming Growth Factor b-Induced Epithelial-Mesenchymal Transition (EMT) of Human Lung Adenocarcinoma Cell Line
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
cancer
human lung adenocarcinoma
lung
ppar-b/d
tgf-b
File:
Download Thesis_Draft_9.pdf
Thesis Supervisors:
Jeffrey Maurice Peters, Thesis Supervisor
Dr. Sarah Ellen Ades, Thesis Honors Advisor
Richard John Frisque, Faculty Reader

53. An Investigation of the Chemotactic Role of Osteoclasts in Breast Cancer Metastasis in Bone

open_access
Open Access
Author:
Pursnani, Richa
Title:
An Investigation of the Chemotactic Role of Osteoclasts in Breast Cancer Metastasis in Bone
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
breast cancer
metastasis
osteoclasts
osteoblasts
chemoattraction
bone
File:
Download PURSNANI_HONORS_THESIS_2014_-_An_Investigation_of_the_Chemotactic_Role_of.pdf
Thesis Supervisors:
Andrea Marie Mastro, Thesis Supervisor
Craig Eugene Cameron, Thesis Honors Advisor
Daniel J Cosgrove, Thesis Honors Advisor
Richard John Frisque, Faculty Reader

54. A Genetic and Biochemical Analysis of the Role of the Ccr4-not Complex in Transcription Elongation and Recovery from DNA Damage in Budding Yeast

open_access
Open Access
Author:
Libert, Diane Marie
Title:
A Genetic and Biochemical Analysis of the Role of the Ccr4-not Complex in Transcription Elongation and Recovery from DNA Damage in Budding Yeast
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
RNA Polymerase II
Transcription Elongation
Transcription-coupled repair
Ccr4-Not
Not4
E3 Ubiquitin Ligase
RING domain
File:
Download Diane_Libert_honors_thesis_PSU_May_2014.pdf
Thesis Supervisors:
Joseph C. Reese, Thesis Supervisor
Chen Pei David Tu, Thesis Honors Advisor
Richard John Frisque, Faculty Reader

55. Identification and Analysis of Dnaj-2 (cg10565) as a Regulator of Synapse Development in the Drosophila Larval Neuromuscular Junction

open_access
Open Access
Author:
Lee, Joyce
Title:
Identification and Analysis of Dnaj-2 (cg10565) as a Regulator of Synapse Development in the Drosophila Larval Neuromuscular Junction
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Drosophila
Neuroscience
Genetics
File:
Download Lee_Joyce-Honors_Thesis_2014.pdf
Thesis Supervisors:
Scott Brian Selleck, Thesis Supervisor
Ming Tien, Thesis Honors Advisor

56. Impact Of Osteoblast-derived Bone Remodeling Cytokines On metastatic Breast Cancer Cell Dormancy

open_access
Open Access
Author:
Rutan, Emily Claire
Title:
Impact Of Osteoblast-derived Bone Remodeling Cytokines On metastatic Breast Cancer Cell Dormancy
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
breast cancer
bone remodeling
cytokines
cancer
dormancy
metastasis
metastases
IL-6
IL-1beta
TNF-alpha
osteoblasts
File:
Download 1-ECR_Thesis_Submit2.pdf
Thesis Supervisors:
Andrea Marie Mastro, Thesis Supervisor
Dr. Teh-hui Kao, Thesis Honors Advisor
Richard John Frisque, Faculty Reader

58. Assessment of Nucleosomal Binding using a High-throughput Interactions by Fluorescent Intensity Assay

open_access
Open Access
Author:
Cognetti, Daniel Joseph
Title:
Assessment of Nucleosomal Binding using a High-throughput Interactions by Fluorescent Intensity Assay
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Gene regulation
Epigenetic
Chromatin
Nucleosome
HI-FI
RCC1
Ran
Histone
Biochemistry
File:
Download Cognetti_Daniel_Assessment.pdf
Thesis Supervisors:
Song Tan, Thesis Supervisor
David Scott Gilmour, Thesis Honors Advisor

59. An examination of behaviors in Drosophila Melanogaster for their utility in an Rnai screen of autism candidate genes

open_access
Open Access
Author:
Saxena, Ritu Shalini
Title:
An examination of behaviors in Drosophila Melanogaster for their utility in an Rnai screen of autism candidate genes
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Autism
Drosophila
Melanogaster
RNAi
screen
gene candidates
behavior
assays
circadian rhythm
geotaxis
social space
File:
Download Ritu_Saxena_BMB_THESIS.pdf
Thesis Supervisors:
Scott Brian Selleck, Thesis Supervisor
David Scott Gilmour, Thesis Honors Advisor

60. The Role of the Rcs Phosphorelay in the Development of Antibiotic Resistance

open_access
Open Access
Author:
Gao, Geoffrey Siyuan
Title:
The Role of the Rcs Phosphorelay in the Development of Antibiotic Resistance
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Rcs phosphorelay
Antibiotic Resistance
Cell Envelope Stress Response
rcsB
rcsA
Beta-lactam antibiotics
Cefsulodin
File:
Download Geoffrey_Gao_Thesis_Final.pdf
Thesis Supervisors:
Dr. Sarah Ellen Ades, Thesis Supervisor
Ming Tien, Thesis Honors Advisor
Scott Brian Selleck, Faculty Reader

63. Mitochondrial Localization and Interactions at Dendritic Branch Points of Drosophila Sensory Neurons

open_access
Open Access
Author:
Weinman-follick, Brandon Matthew
Title:
Mitochondrial Localization and Interactions at Dendritic Branch Points of Drosophila Sensory Neurons
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Neuron
Development
Mitochondria
Drosophila
Dendrite
File:
Download BrandonW-Follick_HonorsThesis_SHC_BMB_Sp15_FinalSubmission.pdf
Thesis Supervisors:
Melissa Rolls, Thesis Supervisor
James Endres Howell, Thesis Honors Advisor
Scott Brian Selleck, Faculty Reader

67. Dissecting the Interactions between S-RNases and S-Locus F-Box Proteins of Petunia during Self/Non-self Recognition in Self Incompatibility

open_access
Open Access
Author:
San Roman, Daniele Marina
Title:
Dissecting the Interactions between S-RNases and S-Locus F-Box Proteins of Petunia during Self/Non-self Recognition in Self Incompatibility
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
self-incompatibility
SLF
S-RNase
s-haplotype
petunia
File:
Download San_Roman__D._Final_Honors_Thesis.pdf
Thesis Supervisors:
Allen T Phillips, Faculty Reader
Dr. Teh-hui Kao, Thesis Honors Advisor
Scott Brian Selleck, Faculty Reader
Dr. Teh-hui Kao, Thesis Supervisor

68. Identifying inhibitors of trans‐translation in methicillin resistant Staphylococcus aureus

open_access
Open Access
Author:
Rae, Christopher Donald
Title:
Identifying inhibitors of trans‐translation in methicillin resistant Staphylococcus aureus
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
methicillin resistant Staphylococcus aureus
MRSA
antibiotic
trans-translation
File:
Download Chris_Rae_Undergraduate_Honors_Thesis.pdf
Thesis Supervisors:
Kenneth Charles Keiler, Thesis Supervisor
Craig Eugene Cameron, Thesis Honors Advisor
Scott Brian Selleck, Faculty Reader

69. Deadly KISS: Kisspeptin 10 Interaction with Osteoblasts and Breast Cancer Metastatic Cells

open_access
Open Access
Author:
Leahey, Kaitlyn Elizabeth
Title:
Deadly KISS: Kisspeptin 10 Interaction with Osteoblasts and Breast Cancer Metastatic Cells
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
breast cancer
metastasis
osteoblasts
KISS1
Kisspeptin 10
cytokines
File:
Download Leahey_Kaitlyn_HonorsThesis2015_DeadlyKISS.pdf
Thesis Supervisors:
Andrea Marie Mastro, Thesis Supervisor
Joseph C. Reese, Thesis Honors Advisor
Dr. Stephen Wade Schaeffer, Thesis Honors Advisor
Scott Brian Selleck, Faculty Reader

71. A Biochemical Analysis of Transcription-coupled Repair Proteins in Yeast and their Role in Transcription Elongation and mrna degradation

open_access
Open Access
Author:
Wing, Anna Kait
Title:
A Biochemical Analysis of Transcription-coupled Repair Proteins in Yeast and their Role in Transcription Elongation and mrna degradation
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
biochemistry
transcription
transcription-coupled repair
DNA repair
mRNA degradation
Ccr4-Not complex
DNA damage
File:
Download Wing_Anna_biochemicalanalysisoftcrproteins.pdf
Thesis Supervisors:
Joseph C. Reese, Thesis Supervisor
Craig Eugene Cameron, Thesis Honors Advisor
Scott Brian Selleck, Faculty Reader

73. Matrix Manipulation Affects Attachment And Growth Of Breast Cancer Cells In A Bone-like Microenvironment In Vitro

open_access
Open Access
Author:
Foster, Shelby Jean
Title:
Matrix Manipulation Affects Attachment And Growth Of Breast Cancer Cells In A Bone-like Microenvironment In Vitro
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
breast cancer
metastasis
bone
estrogen
osteoblast
File:
Download Shelby_Foster_Honors_Thesis.pdf
Thesis Supervisors:
David Scott Gilmour, Thesis Supervisor
Andrea Marie Mastro, Thesis Honors Advisor

74. The Essential Role of the Alternative Sigma Factor, Sigma(E) in Gram Negative Bacteria

open_access
Open Access
Author:
Zappas, Alaina Marie
Title:
The Essential Role of the Alternative Sigma Factor, Sigma(E) in Gram Negative Bacteria
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Gram Negative Bacteria
Cell Stress Response
Alternative Sigma Factor
File:
Download Zappas.Thesis.Final.pdf
Thesis Supervisors:
Dr. Sarah Ellen Ades, Thesis Supervisor
Dr. Sarah Ellen Ades, Thesis Honors Advisor
Kenneth Charles Keiler, Faculty Reader

77. Evidence that ligand activation of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) inhibits TNFα-induced epithelial-to-mesenchymal transition by modulation of SNAIL expression and stemness in human colon cancer cells

open_access
Open Access
Author:
Consevage, Kevin William
Title:
Evidence that ligand activation of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) inhibits TNFα-induced epithelial-to-mesenchymal transition by modulation of SNAIL expression and stemness in human colon cancer cells
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
peroxisome proliferator-activated receptor-β/δ (PPARβ/δ)
File:
Download Final_Thesis.pdf
Thesis Supervisors:
Jeffrey Maurice Peters, Thesis Supervisor
Dr. Wendy Hanna-Rose, Thesis Honors Advisor

78. Determining the role of the RNA Binding Protein HuR in the RNA stability of antizyme and antizyme inhibitor

open_access
Open Access
Author:
Neiman, Margaret Mary
Title:
Determining the role of the RNA Binding Protein HuR in the RNA stability of antizyme and antizyme inhibitor
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
antizyme
antizyme inhibitor
HuR
non-melanoma skin cancer
RNA stability
RNA binding protein
File:
Download Neiman_Margaret_final_thesis.pdf
Thesis Supervisors:
Shannon Lyn Nowotarski, Thesis Supervisor
Jeanne Marie Rose, Thesis Honors Advisor

79. Bacterial Responses to Antibiotic-induced Stresses

open_access
Open Access
Author:
Kilmer, Michelle Renee
Title:
Bacterial Responses to Antibiotic-induced Stresses
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Antibiotic Resistance
Ecological Theory
Cell Envelope Stress Response Pathways
Rcs phosphorelay
Ecological Factors
File:
Download FINAL_THESIS_SUBMISSION__APRIL_11_2016.pdf
Thesis Supervisors:
Dr. Sarah Ellen Ades, Thesis Supervisor
Dr. Sarah Ellen Ades, Thesis Honors Advisor
Kenneth Charles Keiler, Faculty Reader
Scott Brian Selleck, Faculty Reader

80. Role of Heparan Sulfate Proteoglycan Signaling on Autophagy Regulation in Drosophila melanogaster

open_access
Open Access
Author:
Serman, Taryn Mae
Title:
Role of Heparan Sulfate Proteoglycan Signaling on Autophagy Regulation in Drosophila melanogaster
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
HSPG
proteoglycans
autophagy
signaling
cell biology
regulation
File:
Download Taryn_Serman-_Final_Honors_Thesis.pdf
Thesis Supervisors:
Scott Brian Selleck, Thesis Supervisor
David Scott Gilmour, Thesis Honors Advisor

82. Sequencing The Genome Of The Nittany Lion (puma Concolor From Pennsylvania)

open_access
Open Access
Author:
Evanitsky, Maya Nicole
Title:
Sequencing The Genome Of The Nittany Lion (puma Concolor From Pennsylvania)
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
DNA
molecular biology
genetics
mountain lions
puma concolor
ancient DNA
mitochondrial DNA
File:
Download Evanitsky_Maya_Thesis__Final.pdf
Thesis Supervisors:
George H Perry, Thesis Supervisor
Dr. Teh-hui Kao, Thesis Honors Advisor
Dr. Santhosh Girirajan, Thesis Supervisor

87. IDENTIFICATION AND VALIDATION OF CRISPR/CAS9 STAGE-SPECIFIC PROMOTERS AND AN ALTERNATIVE FLUORESCENT REPORTER TO GFP FOR PLASMODIUM YOELII

open_access
Open Access
Author:
Bowman, Laura Marie
Title:
IDENTIFICATION AND VALIDATION OF CRISPR/CAS9 STAGE-SPECIFIC PROMOTERS AND AN ALTERNATIVE FLUORESCENT REPORTER TO GFP FOR PLASMODIUM YOELII
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Malaria
Genetically Attenuated Parasites
CRISPR/Cas9
Stage-Specific Promoters
File:
Download Honors_Thesis.pdf
Thesis Supervisors:
Scott Eugene Lindner, Thesis Supervisor
Dr. Wendy Hanna-Rose, Thesis Honors Advisor

88. The regulation of lipid storage by the splicing factor transformer2 (tra2) in Drosophila

open_access
Open Access
Author:
Mikoluk, Cezary
Title:
The regulation of lipid storage by the splicing factor transformer2 (tra2) in Drosophila
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
tra
tra2
transformer
transformer2
drosophila
melanogaster
CPT1
triglyceride
lipid
storage
splicing
factor
9G8
File:
Download Mikoluk_Cezary_tra2.pdf
Thesis Supervisors:
Justin DiAngelo, Thesis Supervisor
Dr. Sandy Feinstein, Thesis Honors Advisor

91. THE EFFECTS OF INTERNAL HISTONE H3 TRUNCATIONS ON LSD1/COREST DEMETHYLASE ACTIVITY

open_access
Open Access
Author:
Johnston, James Lakshman
Title:
THE EFFECTS OF INTERNAL HISTONE H3 TRUNCATIONS ON LSD1/COREST DEMETHYLASE ACTIVITY
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
James
Johnston
James Johnston
Lakshman
LSD1
CoREST
Histone
Chromatin
H3
Truncations
Structure
Nucleosome
File:
Download JamesJohnstonThesisFinalFixed.pdf
Thesis Supervisors:
Song Tan, Thesis Supervisor
Dr. Teh-hui Kao, Thesis Honors Advisor
Scott Brian Selleck, Faculty Reader

93. ROLE OF COREST N-TERMINAL EXTENSION ON LSD1/COREST DEMETHYLASE ACTIVITY

open_access
Open Access
Author:
Pecen, Turner John
Title:
ROLE OF COREST N-TERMINAL EXTENSION ON LSD1/COREST DEMETHYLASE ACTIVITY
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
LSD1
CoREST
Demethylase
Nucleosome
Binding Assay
Activity Assay
Protein
Biochemistry
Molecular Biology
Complex
File:
Download Pecen_Turner_ROLE_OF_COREST_N-TERMINAL_EXTENSION_ON_LSD1-COREST_DEMETHYLASE_ACTIVITY.pdf
Thesis Supervisors:
Song Tan, Thesis Supervisor
Joseph C. Reese, Thesis Honors Advisor

94. LIPID-MEDIATED LOCALIZATION OF POLIOVIRUS RNA-DEPENDENT RNA POLYMERASE

open_access
Open Access
Author:
Basu, Rohan
Title:
LIPID-MEDIATED LOCALIZATION OF POLIOVIRUS RNA-DEPENDENT RNA POLYMERASE
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Viral replication
poliovirus
replication organelle
3D
RNA-dependent RNA polymerase
File:
Download Basu_Rohan_PV3DThesis.pdf
Thesis Supervisors:
David D Boehr, Thesis Supervisor
Ming Tien, Thesis Honors Advisor
Craig Eugene Cameron, Thesis Supervisor
Scott Brian Selleck, Faculty Reader

95. DEVELOPMENT OF A CRISPR-CAS9 CONSTRUCT AIMED AT KNOCKING OUT SETD2 IN U2OS CELLS

open_access
Open Access
Author:
Schultheis, Nicholas Charles
Title:
DEVELOPMENT OF A CRISPR-CAS9 CONSTRUCT AIMED AT KNOCKING OUT SETD2 IN U2OS CELLS
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
CRISPR
CAS9
SETD2
U2OS
H3K36me3
File:
Download Schultheis_Nicholas_Development_of_a_CRISPR-Cas9_Construct_Aimed_At_Knocking_Out_SetD2_in_U2OS_Cells.pdf
Thesis Supervisors:
Yanming Wang, Thesis Supervisor
Dr. Lorraine C Santy, Thesis Honors Advisor

96. CHARACTERIZING REPLICATION PROTEIN RECRUITMENT AT GAA MICROSATELLITE REPEAT IN A MAMMALIAN PRIMARY REPLICATION CYCLE

open_access
Open Access
Author:
Degiosio, Rebecca Anne
Title:
CHARACTERIZING REPLICATION PROTEIN RECRUITMENT AT GAA MICROSATELLITE REPEAT IN A MAMMALIAN PRIMARY REPLICATION CYCLE
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
microsatellite
DNA replication
mammalian
genomic instability
chromatin immunoprecipitation
quantitative PCR
trinucleotide repeat
Friedreich's Ataxia
File:
Download DeGiosio_Rebecca_GAARepRecruit.pdf
Thesis Supervisors:
Maria Krasilnikova, Thesis Supervisor
Dr. Lorraine C Santy, Thesis Honors Advisor

97. Addressing The Role Of The Not4 E3 Ubiquitin Ligase During DNA Damage-Induced Degradation Of RNAPII In Budding Yeast

open_access
Open Access
Author:
Beebe, Laura M
Title:
Addressing The Role Of The Not4 E3 Ubiquitin Ligase During DNA Damage-Induced Degradation Of RNAPII In Budding Yeast
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
DNA Damage Repair
RNA Polymerase
Yeast
Ubiquitin
Ccr4-Not
Gene Regulation
File:
Download Beebe_Laura_Honors_Thesis_sp2017.pdf
Thesis Supervisors:
Joseph C. Reese, Thesis Supervisor
Joseph C. Reese, Thesis Honors Advisor
David Scott Gilmour, Faculty Reader

98. AN INVESTIGATION OF HYOSCYAMUS NIGER HYOSCYAMINE 6β-HYDROXYLASE ACTIVITY AND IMPROVEMENT OF EXPRESSION METHODS

open_access
Open Access
Author:
Han, Yilin
Title:
AN INVESTIGATION OF HYOSCYAMUS NIGER HYOSCYAMINE 6β-HYDROXYLASE ACTIVITY AND IMPROVEMENT OF EXPRESSION METHODS
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
Biochemistry
Bioinorganic
H6H
Enzyme
File:
Download Han_Yilin_Thesis.pdf
Thesis Supervisors:
Joseph M Bollinger Jr., Thesis Supervisor
David Scott Gilmour, Thesis Honors Advisor

99. Novel Forward Osmosis Desalination Technique Involving an Aquaporin Membrane and a Polyethylene-Glycol-Functionalized Iron Oxide Nanoparticle Draw Solute

open_access
Open Access
Author:
Arnett, Nathan Garner Littlefield
Title:
Novel Forward Osmosis Desalination Technique Involving an Aquaporin Membrane and a Polyethylene-Glycol-Functionalized Iron Oxide Nanoparticle Draw Solute
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
desalination
File:
Download Arnett.Final.pdf
Thesis Supervisors:
Tak-Sing Wong, Thesis Supervisor
Ming Tien, Thesis Honors Advisor

100. DE NOVO SYNTHESIS OF NAD+ CONRTIBUTES TO REPRODUCTIVE DEVELOPMENT IN CAENORHABDITIS ELEGANS

open_access
Open Access
Author:
Holleran, Lauren Michelle
Title:
DE NOVO SYNTHESIS OF NAD+ CONRTIBUTES TO REPRODUCTIVE DEVELOPMENT IN CAENORHABDITIS ELEGANS
Area of Honors:
Biochemistry and Molecular Biology
Keywords:
NAD+
C. elegans
de novo pathway
reproductive development
gonad delay
brood size
umps-1
File:
Download thesis_final_draft.pdf
Thesis Supervisors:
Dr. Wendy Hanna-Rose, Thesis Supervisor
Dr. Teh-hui Kao, Thesis Honors Advisor
Scott Brian Selleck, Faculty Reader