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1. THE ROLE OF CYTOSKELETON PROTEINS IN THE DETERMINATION OF NEURONAL POLARITY

open_access
Open Access
Author:
Han, Anna Q.
Title:
THE ROLE OF CYTOSKELETON PROTEINS IN THE DETERMINATION OF NEURONAL POLARITY
Area of Honors:
Bioengineering
Keywords:
cytoskeleton proteins
cofilin
slingshot
LIM kinase
neuronal polarity
hippocampal neurons
File:
Download Han.Anna.Spring_2010_Thesis.pdf
Thesis Supervisors:
Dr. Gong Chen, Thesis Supervisor
Dr. Gong Chen, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Peter J Butler, Faculty Reader

2. THE EFFECTS OF THE TUMOR MICROENVIRONMENT ON ENDOTHELIAL CELLULAR ADHESION MOLECULE EXPRESSION

open_access
Open Access
Author:
Goodrich, Christopher James
Title:
THE EFFECTS OF THE TUMOR MICROENVIRONMENT ON ENDOTHELIAL CELLULAR ADHESION MOLECULE EXPRESSION
Area of Honors:
Bioengineering
Keywords:
cancer
metastasis
adhesion
ICAM-1
File:
Download Thesis_Reviewed_Final_-_Christopher_Goodrich.pdf
Thesis Supervisors:
Cheng Dong, Thesis Supervisor
Cheng Dong, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Peter J Butler, Faculty Reader

3. A Computational Study of Airflow in a Standardized Human Nasal Cavity: Implications Regarding Olfaction

open_access
Open Access
Author:
Shenk, Elizabeth Marie
Title:
A Computational Study of Airflow in a Standardized Human Nasal Cavity: Implications Regarding Olfaction
Area of Honors:
Bioengineering
Keywords:
human olfaction
nasal airflow
standardized human nasal cavity
CFD analysis
File:
Download Shenk_Thesis.pdf
Thesis Supervisors:
Brent A Craven, Thesis Supervisor
Brent A Craven, Thesis Supervisor
Dr. William O Hancock, Thesis Supervisor
Peter J Butler, Faculty Reader

4. Improving Carbon Fiber Microelectrode Performance for Measuring Serotonin by Voltammetry

open_access
Open Access
Author:
Sawarynski, Lauren Elizabeth
Title:
Improving Carbon Fiber Microelectrode Performance for Measuring Serotonin by Voltammetry
Area of Honors:
Bioengineering
Keywords:
serotonin
carbon fiber microelectrodes
voltammetry
File:
Download LSawarynski_FinalThesis.pdf
Thesis Supervisors:
Dr. Anne Milasincic Andrews, Ph D, Thesis Supervisor
Dr. Anne Milasincic Andrews, Ph D, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Peter J Butler, Faculty Reader

5. THE EFFECTS OF MULTIPLE KINESIN MOTORS ON CARGO TRANSPORT VELOCITY

open_access
Open Access
Author:
Bizzaro, Nicholas Robert
Title:
THE EFFECTS OF MULTIPLE KINESIN MOTORS ON CARGO TRANSPORT VELOCITY
Area of Honors:
Bioengineering
Keywords:
motor proteins
kinesin
cellular transport
File:
Download Schreyer_Honors_College_Thesis_-_Nicholas_Bizzaro.pdf
Thesis Supervisors:
Dr. William O Hancock, Thesis Supervisor
Dr. William O Hancock, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Peter J Butler, Faculty Reader
Margaret June Slattery, Faculty Reader

6. THE CHARACTERIZATION OF A MICROCHANNEL DEVICE USING LASER BASED MICRO-PIV

open_access
Open Access
Author:
Wang , Sicong
Title:
THE CHARACTERIZATION OF A MICROCHANNEL DEVICE USING LASER BASED MICRO-PIV
Area of Honors:
Bioengineering
Keywords:
microchannel
microfluidics
micro-PIV
soft lithography
murray law
circulating tumor cell
velocity profile
volumetric flow rate
pulastive flow
PDMS
File:
Download THECHARACTERIZATION_OF_MICROCHANNEL_DEVICE_USING_LASER_BASEDMICROPIV.pdf
Thesis Supervisors:
Siyang Zheng, Thesis Supervisor
Siyang Zheng, Thesis Supervisor
Peter J Butler, Thesis Honors Advisor
Dr. William O Hancock, Faculty Reader

8. Feasibility Studies for Optical Trap Detection of Single Molecule Adhesion and Force Generation

open_access
Open Access
Author:
Bernick, David J
Title:
Feasibility Studies for Optical Trap Detection of Single Molecule Adhesion and Force Generation
Area of Honors:
Bioengineering
Keywords:
optical trap
laser tweezers
integrin ligand binding
bead
avidin
biotin
microscopy
File:
Download Final_Thesis_Bernick_David_Optical_Trap.pdf
Thesis Supervisors:
Peter J Butler, Thesis Supervisor
Peter J Butler, Thesis Honors Advisor
Dr. Keefe B Manning, Faculty Reader
Dr. William O Hancock, Faculty Reader

10. Finite Element Analysis of Microfabricated Poly(Glycerol Sebacate) Scaffolds for use in Heart Valve Tissue Engineering

open_access
Open Access
Author:
Chowdhury, Surjyanil
Title:
Finite Element Analysis of Microfabricated Poly(Glycerol Sebacate) Scaffolds for use in Heart Valve Tissue Engineering
Area of Honors:
Bioengineering
Keywords:
Chowdhury
finite element
COMSOL
heart valve
tissue engineering
poly glycerol sebacate
PGS
microfabricate
scaffold
mesh
File:
Download honors_thesis_final_draft.pdf
Thesis Supervisors:
Dr. William O Hancock, Thesis Supervisor
Peter J Butler, Thesis Honors Advisor
Dr. Keefe B Manning, Faculty Reader

11. The effect of substrate stiffness on fibrillin expression by mouse embryonic fibroblasts (MEFs)

open_access
Open Access
Author:
Sheldrake, Anne E
Title:
The effect of substrate stiffness on fibrillin expression by mouse embryonic fibroblasts (MEFs)
Area of Honors:
Bioengineering
Keywords:
MEFs
tissue engineering
cardiac
acrylamide
bisacrylamide
heart
fibrillin
scar tissue
File:
Download sheldrake_anne_effect_of_susbstrate_stiffness.pdf
Thesis Supervisors:
Dr. Justin Lee Brown, Thesis Supervisor
Peter J Butler, Thesis Honors Advisor
Dr. William O Hancock, Faculty Reader

16. Fluid Dynamic Studies of a Porcine Aortic Valve in Preparation for Future Living Tissue Valve Studies

open_access
Open Access
Author:
Schmiech, Kathryn Victoria
Title:
Fluid Dynamic Studies of a Porcine Aortic Valve in Preparation for Future Living Tissue Valve Studies
Area of Honors:
Bioengineering
Keywords:
aortic valve
fluid dynamics
porcine valve
particle image velocimetry
File:
Download KSchmiechFinalThesis.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Peter J Butler, Faculty Reader

17. Investigating the Mechanics of Cancer Cell Membranes Using Microfluidics

open_access
Open Access
Author:
Ramadi, Khalil Basil
Title:
Investigating the Mechanics of Cancer Cell Membranes Using Microfluidics
Area of Honors:
Bioengineering
Keywords:
Cancer
CTC
Isolation
Characterization
Tumor
Membrane
Mechanics
Cell
Expansion
Osmosis
Microfluidics
Viscoelasticity
File:
Download Thesis_Final_final_v2.pdf
Thesis Supervisors:
Siyang Zheng, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Peter J Butler, Faculty Reader

18. Effects of Synonymous, Consecutive, Repetitive Codons on Bacterial Translation Elongation Rates

open_access
Open Access
Author:
Heasley, Victoria Lynn
Title:
Effects of Synonymous, Consecutive, Repetitive Codons on Bacterial Translation Elongation Rates
Area of Honors:
Bioengineering
Keywords:
repetitive codon sequences elongation
affects on translation elongation rates
synthetic biology
genetic engineering
File:
Download Heasley_Victoria__Effects_of_Repetitive_Codons_on_Elongation.pdf
Thesis Supervisors:
Howard M Salis, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Peter J Butler, Faculty Reader

19. An Experimental Setup to Test the Effects of Shear Stress on von Willebrand Factor

open_access
Open Access
Author:
Corsetti, Monica Claire
Title:
An Experimental Setup to Test the Effects of Shear Stress on von Willebrand Factor
Area of Honors:
Bioengineering
Keywords:
von Willebrand Factor
vWF
Optical Trap
Optical Tweezers
Shear Stress
Acquired von Willebrand Syndrome
ADAMTS-13
File:
Download Thesis_Monica_Corsetti.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Peter J Butler, Faculty Reader
Dr. William O Hancock, Faculty Reader
Dr. Keefe B Manning, Thesis Honors Advisor

20. Nanofiber Control of Focal Adhesion Dynamics and Cell Migration for Regenerative Medicine

open_access
Open Access
Author:
Riley, Thomas Roberts
Title:
Nanofiber Control of Focal Adhesion Dynamics and Cell Migration for Regenerative Medicine
Area of Honors:
Bioengineering
Keywords:
Matlab
Image Processing
Focal Adhesion
Cell Migration
Nanofiber
Tissue Engineering
Regenerative Medicine
FAITS
File:
Download RileyThesisFinalDraft.pdf
Thesis Supervisors:
Dr. Justin Lee Brown, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Peter J Butler, Faculty Reader

21. Histological Analysis of in vitro Thrombus Formation in a Backward Facing Step Flow Domain Using Carstairs' Stain

open_access
Open Access
Author:
Kinney, Joanna E
Title:
Histological Analysis of in vitro Thrombus Formation in a Backward Facing Step Flow Domain Using Carstairs' Stain
Area of Honors:
Bioengineering
Keywords:
thrombosis
histology
bioengineering
heart
blood
File:
Download Kinney_Joanna_Thesis_Final.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Peter J Butler, Faculty Reader

22. A Fluid Dynamic Study of the Effect of Hematocrit in the 12 cc Penn State Pediatric Ventricular Assist Device

open_access
Open Access
Author:
Silver, Jeremy Michael
Title:
A Fluid Dynamic Study of the Effect of Hematocrit in the 12 cc Penn State Pediatric Ventricular Assist Device
Area of Honors:
Bioengineering
Keywords:
ventricular assist device
pediatric
cardiovascular device
hematocrit
thrombosis
particle image velocimetry
piv
VAD
PVAD
File:
Download Silver_SHC_Thesis_FINAL.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Dr. Keefe B Manning, Thesis Honors Advisor
Dr. William O Hancock, Faculty Reader
Peter J Butler, Faculty Reader

23. Targeted Sequencing Of Chromosome 9 Genes Associated With Papillary Type 1 Renal Cell Carcinoma

open_access
Open Access
Author:
Belsky, Michael Alan
Title:
Targeted Sequencing Of Chromosome 9 Genes Associated With Papillary Type 1 Renal Cell Carcinoma
Area of Honors:
Biomedical Engineering
Keywords:
Cancer
next generation sequencing
renal cell carcinoma
targeted sequencing
papillary type 1
File:
Download Belsky_Thesis_Final.pdf
Thesis Supervisors:
Dr. William O Hancock, Thesis Supervisor
Peter J Butler, Thesis Honors Advisor
Dr. William A La Framboise, Faculty Reader

24. Single-molecule microscopy step detection algorithms: kinesin motor proteins and the cellulose synthesis complex

open_access
Open Access
Author:
Deffenbaugh, Nathan C
Title:
Single-molecule microscopy step detection algorithms: kinesin motor proteins and the cellulose synthesis complex
Area of Honors:
Bioengineering
Keywords:
kinesin
motor proteins
step detection
single-molecule
cellulose synthesis complex
hidden Markov model
File:
Download DeffenbaughNathan_SHCThesis_May2015.pdf
Thesis Supervisors:
Dr. William O Hancock, Thesis Supervisor
Peter J Butler, Faculty Reader
Dr. Justin Lee Brown, Faculty Reader
Dr. William O Hancock, Thesis Honors Advisor

26. Comparing Novel Techniques for Measuring the Bending Modulus of Lipid Bilayer Membranes in Erythrocytes

open_access
Open Access
Author:
Frazzette, Nicholas James
Title:
Comparing Novel Techniques for Measuring the Bending Modulus of Lipid Bilayer Membranes in Erythrocytes
Area of Honors:
Bioengineering
Keywords:
mechanobiology
bending modulus
mechanotransduction
lipid bilayers
membrane bending
erythrocytes
TCSPC
fluorescence
File:
Download Frazzette_SHC_Thesis_v4.pdf
Thesis Supervisors:
Peter J Butler, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Herbert Herling Lipowsky, Faculty Reader

28. The impact of genetic variants on kinesin motor proteins and the link to neurological disorders

open_access
Open Access
Author:
Erdman, Marcus Orion
Title:
The impact of genetic variants on kinesin motor proteins and the link to neurological disorders
Area of Honors:
Biomedical Engineering
Keywords:
kinesin
neurological disorder
mutation
genomics
File:
Download Thesis_final_Marcus_Erdman.pdf
Thesis Supervisors:
Dr. William O Hancock, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Peter J Butler, Faculty Reader
Dr. Justin Lee Brown, Faculty Reader

30. Determining Embolus Trapping Efficiency of an Inferior Vena Cava Filter during Exercise

open_access
Open Access
Author:
Riley, Joshua Mackey
Title:
Determining Embolus Trapping Efficiency of an Inferior Vena Cava Filter during Exercise
Area of Honors:
Biomedical Engineering
Keywords:
Inferior Vena Cava Filter
IVC Filter
Pulmonary Embolism
Trapping Efficiency
File:
Download Riley_Final_Thesis.pdf
Thesis Supervisors:
Dr. Keefe B Manning, Thesis Supervisor
Dr. William O Hancock, Thesis Honors Advisor
Peter J Butler, Faculty Reader